Pharmacogenetics - Science topic

There exist over 600 neurological conditions, each characterized by unique pathologies tailored to individual patients. Over the past two decades, advances in biotechnology have propelled the field of neurogenetics forward. This progress has illuminated therapeutic targets and methodologies tailored to the specific needs of each patient. Current tr...

Introduction. Treatment of patients with superficial burns remains one of the important problems of clinical medicine. Local treatment of burns should ensure the change of the processes of degeneration to inflammation and regeneration due to the reduction of the number of pathological bacteria and optimization of the wound process. In the local tre...

Aims The aim of the present study was to investigate the impact of CYP2D6 genotype on exposure and metabolism of escitalopram in patients stratified by CYP2C19 genotype in a large real‐world population. Methods Patients were included from a therapeutic drug monitoring service if they had measured serum concentration of escitalopram and the metabol...

Next‐generation sequencing (NGS) significantly enhances precision medicine (PM) by offering personalized approaches to diagnosis, treatment, and prevention of unmet medical needs. Little is known about the current situation of PM in Asia. Thus, we aimed to conduct an overview of the progress and gaps in PM in Asia and enrich it with in‐depth insigh...

Siponimod is a selective immunosuppressive medication, developed as the first oral therapy for active secondary progressive multiple sclerosis. This medication acts by modulating the sphingosine 1 phosphate (S1P) receptor, as an antagonist of S1P1 and S1P5, thus preventing the egress of lymphocytes from lymph nodes and preventing inflammatory proce...

Penelitian ini bertujuan untuk menganalisis dan mengetahui ada tidaknya perbedaan penjualan yang signifikan antara PT Sido Muncul Tbk dengan. PT Indo Farma Tbk. Jenis penelitian ini termasuk jenis penelitian komparatif yaitu membandingkan keberadaan satu variabel atau lebih pada dua sampel yang berbeda, atau pada waktu yang berbeda. Metode pengumpu...

The tyrosine kinase Inhibitor (TKI) imatinib is approved for the treatment of the chronic phase of chronic myeloid leukemia (CP-CML). Pharmacokinetic studies have highlighted the importance of inter-patient variability on imatinib plasma trough concentrations (ima[C]min). In the OPTIM-imatinib trial, we demonstrated that therapeutic drug monitoring...

Nimodipine, an L-type cerebroselective calcium channel antagonist, is the only drug approved by the US Food and Drug Administration for the neuroprotection of patients with aneurysmal subarachnoid hemorrhage (aSAH). Four randomized, placebo-controlled trials of nimodipine demonstrated clinical improvement over placebo; however, these occurred befor...

Genetic screening for HLA‐B*15:02 before prescribing carbamazepine is standard practice to prevent severe cutaneous adverse reactions in Asian populations. These reactions are associated not only with this allele but also with closely related HLA‐B75 serotype markers—HLA‐B*15:11 and HLA‐B*15:21—which are prevalent in several Asian countries. Howeve...

Imatinib is the tyrosine kinase inhibitor used as the gold standard for the treatment of Chronic Myeloid Leukemia. However, about 30% of patients do not respond well to this therapy. Variants in drug administration, distribution, metabolism and excretion (ADME) genes play an important role in drug resistance especially in admixed populations. We in...

This study endeavors to evaluate the effectiveness of green distribution and green supply chain practices at PT Bio Farma (Persero) in relation to polio vaccine products. The ultimate objective is to establish and attain future green distribution targets. The research methodology utilizes the Green Supply Chain Operations Reference (Green SCOR) mod...

Introduction: Acute lymphoblastic leukemia (ALL) is the most frequent pediatric leukemia; it can be defined according to chromosomic and genomic data. Cytogenetic analyses and determination of chromosomal numbers (such as hypo- or hyperdiploidy) and/or specific chromosomal rearrangements are basic for ALL classification and treatment. Even though c...

Since the identification of vacuolar protein sorting (VPS) 35, as a causative molecule for familial Parkinson’s disease (PD), retromer-mediated endosomal machinery has been a rising factor in the pathogenesis of the disease. The retromer complex cooperates with sorting nexin (SNX) dimer and DNAJC13, another causal molecule in PD, to transport cargo...

Nutrition is considered to be one of the main factors ensuring vital activity. Its comp­leteness and compliance with metabolic needs are especially important for people in emer­gencies. Therefore, consuming (using) food products for special medical purposes has become quite widespread. It has been establi­shed that this product market segment is sh...

Aims Pharmacogenetics (PGx) is increasingly recognized as a strategy for medicines optimisation and prevention of adverse drug reactions. According to guidelines produced by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetic Working Group (DPWG), most medicines with drug‐gene interactions (DGIs) are prescri...

The retail segment has the largest contribution to the total net sales value of Kimia Farma Group, which is run by the company's subsidiary, PT Kimia Farma Apotek (KFA). Kimia Farma's retail segment is experiencing a relatively non-ideal revenue trend from 2017 to 2022. The main challenges faced are the purchasing power of the community, the increa...

Background In many countries, infant vaccination with acellular pertussis (aP) vaccines has replaced use of more reactogenic whole-cell pertussis (wP) vaccines. Based on immunological and epidemiological evidence, we hypothesised that substituting the first aP dose in the routine vaccination schedule with wP vaccine might protect against IgE-mediat...

In this study, we investigated the combined influence of pregnancy and genetic polymorphisms on efavirenz pharmacokinetics in cervicovaginal fluid (CVF) of women receiving antiretroviral therapy. Women receiving efavirenz‐containing antiretroviral therapy were recruited from two hospitals in Nigeria during 2017–2020. Sparse CVF and plasma samples w...

Computational methods analyze genomic data to identify genetic variants linked to drug responses, thereby guiding personalized medicine. This study analyzed 942 whole‐genome sequences from the Electricity Generating Authority of Thailand (EGAT) cohort to establish a population‐specific pharmacogenomic database (TPGxD‐1) in the Thai population. Sent...

Antiplatelet therapy, the gold standard of care for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI), is one of the therapeutic approaches most associated with the development of adverse drug reactions (ADRs). Although numerous studies have shown that pharmacological intervention based on a limited num...

Purpose. Catechol-O-methyltransferase (COMT) participates in the regulation of dopaminergic and adrenergic neurotransmission. COMT Val158Met polymorphism influences the efficacy and safety of opioids, but its association with oxycodone treatment in patients with cancer pain is yet to be elucidated. Hence, this study aimed to investigate the influen...

Individualized treatment rules tailor treatments to patients based on clinical, demographic, and other characteristics. Estimation of individualized treatment rules requires the identification of individuals who benefit most from the particular treatments and thus the detection of variability in treatment effects. To develop an effective individual...

Cellular senescence in cardiomyocytes, characterized by cell cycle arrest, resistance to apoptosis, and the senescence-associated secretory phenotype, occurs during aging and in response to various stresses, such as hypoxia/reoxygenation, ischemia/reperfusion, myocardial infarction (MI), pressure overload, doxorubicin treatment, angiotensin II, dia...

The contribution of dermatologists to global oncology also remains largely attributable to the incidental identification or clinicopathologic correlations between the intake of nitrosamine-contaminated drugs and the subsequent generation of melanomas and keratinocytic cancers. The slow and gradual identification of an increasing number of nitrosami...

Approximately one-third of patients with major depression do not improve sufficiently even after multiple trials of otherwise effective antidepressant treatments, meeting criteria for treatment-resistant depression (TRD). The phenomenon of TRD remains poorly understood, as it can be attributed to a myriad of diverse factors, including pharmacogenet...

The aim was to determine if opioid neuroimmunopharmacology pathway gene polymorphisms alter serum morphine, morphine-3-glucuronide and morphine-6-glucuronide concentration-response relationships in 506 cancer patients receiving controlled-release oral morphine. Morphine-3-glucuronide concentrations (standardised to 11 h post-dose) were higher in pa...

Objective Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) is currently used in clinical microbiology laboratories. This study aimed to determine whether dual-polarity time-of-flight mass spectrometry (DP-TOF MS) could be applied to clinical nucleotide detection. Methods This prospective study included 40...

Pharmacogenetic (PGx)‐informed medication prescription is a cutting‐edge genomic application in contemporary medicine, offering the potential to overcome the conventional “trial‐and‐error” approach in drug prescription. The ability to use an individual's genetic profile to predict drug responses allows for personalized drug and dosage selection, th...

This ABIGENE pharmacokinetic (PK) study sought mainly to characterize the unchanged drug PK during long-term abiraterone acetate (AA) administration in advanced prostate cancer patients (81 patients). It was observed that individual AA concentrations remained constant over treatment time, with no noticeable changes during repeated long-term drug ad...

Purpose of review Major depressive disorder is a prevalent psychiatric illness associated with significant morbidity, mortality, and economic burden worldwide. Despite the widespread use of antidepressants, remission rates among those treated with antidepressants remain low. Opportunities to personalize medication choices and doses and optimize cli...

Individual may response to drug treatment differently due to their genetic variants located in enhancers. These variants can alter transcription factor’s (TF) binding strength, affect enhancer’s chromatin activity or interaction, and eventually change expression level of downstream gene. Here, we propose a computational framework, PERD, to Predict...

Over the last few decades, the implementation of pharmacogenomics (PGx) in clinical practice has improved tailored drug prescriptions [...]

Citation: Rosendo, L.M.; Rosado, T.; Zandonai, T.; Rincon, K.; Peiró, A.M.; Barroso, M.; Gallardo, E. Opioid Monitoring in Clinical Settings: Strategies and Implications of Tailored Approaches for Therapy. Int. J. Mol. Sci. 2024, 25, 5925. https://doi. Abstract: This review emphasises the importance of opioid monitoring in clinical practice and adv...

Background Tailoring antidepressant drugs (AD) to patients’ genetic drug-metabolism profile is promising. However, literature regarding associations of ADs’ treatment effect and/or side effects with drug metabolizing genes CYP2D6 and CYP2C19 has yielded inconsistent results. Therefore, our aim was to longitudinally investigate associations between...

Lack of efficacy or adverse drug response are common phenomena in pharmacological therapy causing considerable morbidity and mortality. It is estimated that 20–30% of this variability in drug response stems from variations in genes encoding drug targets or factors involved in drug disposition. Leveraging such pharmacogenomic information for the pre...

Atrial fibrillation (AF) accounts for 40% of all cardiac arrhythmias and is associated with a high risk of stroke and systemic thromboembolic complications. Dabigatran, rivaroxaban, apixaban, and edoxaban are direct oral anticoagulants (DOACs) that have been proven to prevent stroke in patients with non-valvular AF. This review summarizes the pharm...

Title A systematic review of pharmacogenetic guided opioid therapy for pain. Authors Sneha Jethwa Contact: Sj648@cam.ac.uk University of Cambridge Contributions Dr Kenneth Langlands Rationale Genetic polymorphisms have been shown to have a role in the variability in response to analgesics. Clinical Pharmacogenetics Implementation Consortium (CPIC)...

Sickle cell disease (SCD) continues to pose a significant public health challenge, particularly in sub-Saharan Africa. Despite its discovery over a century ago, the progress in developing and accessing effective interventions has been notably restricted. Currently, hydroxyurea stands as the primary drug in widespread use, and has been associated wi...

Genetic biomarkers could potentially lower the risk of treatment failure in chronic inflammatory diseases (CID) like psoriasis, psoriatic arthritis (PsA), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD). We performed a systematic review and meta-analysis assessing the association between single nucleotide polymorphisms (SNPs) and re...

Introduction: Genomic healthcare applications have relevance to all healthcare professionals including nursing, and most evidence-based clinical applications impact the quality and safety of healthcare. To guide nursing genomic competency initiatives, the Essential Nursing Competencies and Curricula Guidelines for Genetics and Genomics were establ...

En 1983, hace 40 años, Howard Gardner publicó "Farmae Mentis", un ensayo que estaba destinado a revolucionar el enfoque psicológico de la inteligencia y, a partir de ahí, a influir enormemente en el mundo de la investigación (y la práctica) educativa en todo el mundo. Unos veinte años después de su publicación, algunas investigaciones han puesto de...

Nel 1983, 40 anni fa, Howard Gardner pubblicava "Farmae Mentis" un saggio destinato a rivoluzionare l'approccio psicologico all'intelligenza, e da qui a influire enormemente nel mondo della ricerca (e pratica) pedagogica a livello mondiale. Dopo circa vent'anni dalla sua pubblicazione, alcune ricerche hanno posto in evidenza alcune lacune dell'impi...

Introduction Patients with chronic limb threatening ischaemia (CLTI) are often prescribed clopidogrel in order to reduce their risk of major adverse limb and cardiovascular events. Clopidogrel is metabolised by the CYP2C19 enzyme, and genetics variations in CYP2C19 are common. These variants can influence an individual’s ability to metabolise clopi...

Introducción: Los polimorfismos genéticos en las enzimas hepáticas de metabolización son una de las principales razones de las diferencias interindividuales en la respuesta a los fármacos. La mayoría de los medicamentos serotoninérgicos son metabolizados por la isoforma CYP2D6 del CYP450, por tanto, variaciones en la secuencia del gen que codifica...

Aminobisphosphonates (NBPs) are the first-choice medication for osteoporosis (OP); NBP treatment aims at increasing bone mineral density (BMD) by inhibiting the activity of farnesyl diphosphate synthase (FDPS) enzyme in osteoclasts. Despite its efficacy, inadequate response to the drug and side effects have been reported. The A allele of the rs2297...

Metabolism of praziquantel (PZQ), a racemic mixture and the only drug approved to treat S. mansoni infection, is mediated by genetically polymorphic enzymes. Periodic school-based mass drug administration (MDA) with PZQ is the core intervention to control schistosomiasis. However data on the impact of pharmacogenetic variation, nutrition, and infec...

Variant allele at the inosine monophosphate dehydrogenase type 2 polymorphism IMPDH2 3757T>C has been associated with increased enzyme activity and reduced susceptibility to mycophenolic acid (MPA) in vitro. It has been suggested associated with an increased risk of acute rejection in renal transplant recipients on MPA-based immunosuppression, but...

Background Human dermal fibroblasts (HDFs) are essential in the processes of skin ageing and wound healing. However, the underlying mechanism of HDFs in skin healing of the elderly has not been well defined. This study aims to elucidate the mechanisms of HDFs senescence and how senescent HDFs affect wound healing in aged skin. Methods The expressi...

Background Currently, empiric treatment of major depressive disorder (MDD) relies on the characteristics of the presenting patients. Aim The aim of the current study was to identify moderators for the association of SSRI treatment efficacy response phenotype with genotypes of HTR1A-rs6295 or HTR2A-rs6311 polymorphism in a population of MDD patient...

Particular attention was paid to the application of current knowledge on drug interactions. However, with the exception of some notable drug-nutrient interactions (e.g., with grapefruit juice, alcohol, and caffeine), few physicians and pharmacists advise their patients on how to minimize the risks associated with drug-nutrient interactions. Risk f...

Introduction DNA-informed prescribing (termed pharmacogenomics, PGx) is the epitome of personalised medicine. Despite international guidelines existing, its implementation in paediatric oncology remains sparse. Methods and analysis Minimising Adverse Drug Reactions and Verifying Economic Legitimacy-Pharmacogenomics Implementation in Children is a...

Background Chronic pain is a major socioeconomic burden in the Mediterranean region. However, we noticed an under-representation of these populations in the pharmacogenetics of pain management studies. In this context, we aimed 1) to decipher the pharmacogenetic variant landscape among Mediterranean populations compared to worldwide populations in...

According to the WHO target product profile for COVID-19 vaccines, the vaccine in development should be indicated for active immunisation in all populations. Therefore, PT Bio Farma developed a candidate vaccine in a subunit protein recombinant platform to help overcome the issue. This trial was an observer-blind, randomised, prospective interventi...

Penelitian ini berangkat dari maraknya kasus fraud pada perusahaan yang terjadi pada PT Kimia Farma Tbk dan PT Indofarma Tbk. Kajian ini ditujukan guna dapat melakukan pengujian variabel penyebab fraud dalam mendeteksi potensi terjadinya fraud di perusahaan manufaktur yang ada pada BEI periode tahun 2020-2022 yang mengacu pada fraud hexagon theory....

Background. Side effects of endocrine therapy with tamoxifen (TAM) reduce the quality of life of patients with breast cancer (BC) and adversely affect treatment compliance. Against the background of treatment of BC with TAM, the risk of developing endometrial hyperplasia (EH) increases. At the moment, algorithms for monitoring patients receiving TA...

Perkembangan global usaha saat ini diikuti dengan perkembangan teknologi informasi dan komunikasi. media sosial ialah komunikasi sosial antar manusia pada mengembangkan serta bertukar info. media sosial bisa memuat aneka macam ilham, opini, persepsi, serta konten pada komunitas impian serta dapat menyajikan serta menerjemahkan cara-cara komunikasi...

The safety of the use of psychotropic drugs, widely used in neurological and psychiatric practice, is an urgent problem in personalized medicine. This narrative review demonstrated the variability in allelic frequencies of low-functioning and non-functional single nucleotide variants in genes encoding key isoenzymes of valproic acid P-oxidation in...

Mendelian randomization uses genetic variants as instrumental variables to estimate the causal effect of a modifiable health exposure or drug target on a downstream outcome. A crucial assumption for accurate estimation of the average causal effect in MR, termed Homogeneity, is that the causal effect does not vary across levels of any instrument use...

Background: Current treatments for chronic hepatitis B management include orally administered nucleos(t)ide analogues, such as tenofovir (TDF), which is an acyclic adenine nucleotide analogue used both in HBV and human immune deficiency virus (HIV). The course of HBV infection is mainly dependent on viral factors, such as HBV genotypes, immunologic...

This Special Issue aims to discuss developments in pharmacogenetics methodology and how these developments have made it possible to assess the full extent of pharmacological variants and improve the identification, functional validation and mechanistic understanding of the interplay between genes and drugs. I am looking forward to receiving your h...

Defining genetic factors impacting chemotherapy failure can help to better predict response and identify drug resistance mechanisms. However, there is limited understanding of the contribution of inherited noncoding genetic variation on inter-individual differences in chemotherapy response in childhood acute lymphoblastic leukemia (ALL). Here we ma...

The clinical application of Pharmacogenomics (PGx) has improved patient safety. However, comprehensive PGx testing has not been widely adopted in clinical practice, and significant opportunities exist to further optimize PGx in cancer care. This systematic review and meta‐analysis aim to evaluate the safety outcomes of reported PGx‐guided strategie...

Background Despite efforts made to reduce morbidity and mortality associated with malaria, especially in sub-Saharan Africa, malaria continues to be a public health concern that requires innovative efforts to reach the WHO-set zero malaria agenda. Among the innovations is the use of artemisinin-based combination therapy (ACT) that is effective agai...

Major Depressive Disorder (MDD) is a chronic disorder characterized by at least a two-week-long major depressive episode. Selective Serotonin Reuptake Inhibitors (SSRIs) remain the primary prescribed antidepressants to treat MDD. However, SSRIs themselves are found to be ineffective in some individuals or may even lead to adverse side effects. Thes...

Suspected adverse drug reactions (ADRs) during treatment with clozapine often prompt therapeutic drug monitoring (TDM) in clinical practice. Currently, there is no official recommendation for pharmacogenetic (PGx) testing in the context of clozapine therapy. In this case report, we demonstrate and discuss the challenges of interpreting PGx and TDM...

Introduction: To study the effects of drug-induced CYP2D6 activity inhibition and genetic polymorphisms on fluoxetine metabolism, rat liver microsomes (RLMs) and SD rats were used to investigate the potential drug‒drug interactions (DDIs), and CYP2D6 http://muchong.com/t-10728934-1 recombinant baculosomes were prepared and subjected to catalytic re...

Polypharmacy is a global healthcare concern, especially among the elderly, leading to drug interactions and adverse reactions, which are significant causes of death in developed nations. However, the integration of pharmacogenetics can help mitigate these risks. In this study, the data from 483 patients, primarily elderly and polymedicated, were an...

Purpose The current candidate gene association study aims to investigate tag SNPs from the TACR1 gene as pharmacogenetic predictors of response to the antiemetic guidelines-recommended, NK-1 receptor antagonist-based, triple antiemetic regimens. Methods A set of eighteen tag SNPs of TACR1 were genotyped in breast cancer patients receiving anthracy...

Background. Cytarabine-anthracycline based induction chemotherapy remains the standard of care for remission induction among patients with newly diagnosed acute myeloid leukaemia (AML). There are remarkable differences in therapy response among AML patients. This fact could be partly explained by the patients’ genetic variability related to metabol...

In Peru, 29 292 people were diagnosed with tuberculosis in 2022. Although tuberculosis treatments are effective, 3.4%–13% are associated with significant adverse drug reactions, with drug‐induced liver injury (DILI) considered the most predominant. Among the first‐line antituberculosis drugs, isoniazid is the main drug responsible for the appearanc...

Tacrolimus (Tac) is pivotal in preventing acute graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT). It has been reported that genetic factors, including CYP3A5*3 and CYP3A4*22 polymorphisms, have an impact on Tac metabolism, dose requirement, and response to Tac. There is limited information regardi...

Fluoropyrimidines, crucial in cancer treatment, often cause toxicity concerns even at standard doses. Toxic accumulation of fluoropyrimidine metabolites, culminating in adverse effects, can stem from impaired dihydropyrimidine dehydrogenase (DPYD) enzymatic function. Emerging evidence underscores the role of single nucleotide polymorphisms (SNPs) i...

Background. In the paediatric liver transplant programme in Johannesburg, South Africa (SA), tacrolimus is the calcineurin inhibitor of choice, comprising an essential component of the immunosuppression regimen. It is characterised by a narrow therapeutic index and wide interpatient variability, necessitating therapeutic drug monitoring of whole-bl...

The nomenclature of star alleles has been widely used in pharmacogenomics to enhance treatment outcomes, predict drug response variability, and reduce adverse reactions. However, the discovery of numerous rare functional variants through genome sequencing introduces complexities into the star-allele system. This study aimed to assess the nature and...

Background CYP2C8 is responsible for the metabolism of 5% of clinically prescribed drugs, including antimalarials, anti-cancer and anti-inflammatory drugs. Genetic variability is an important factor that influences CYP2C8 activity and modulates the pharmacokinetics, efficacy and safety of its substrates. Results We profiled the genetic landscape o...

Background Lupus nephritis (LN) is a complication of SLE characterised by immune dysfunction and oxidative stress (OS). Limited options exist for LN. We aimed to identify LN-related OS, highlighting the need for non-invasive diagnostic and therapeutic approaches. Methods LN-differentially expressed genes (DEGs) were extracted from Gene Expression...

Background Empirical use of pharmacogenetic test(PGT) is advocated for many drugs, and resource-rich setting hospitals are using the same commonly. The clinical translation of pharmacogenetic tests in terms of cost and clinical utility is yet to be examined in hospitals of low middle income countries (LMICs). Aim The present study assessed the cli...

Objetivos: Determinar la relación entre eficiencia metabólica del CYP2B6 con la aparición de efectos con potencial de abuso (PA), craving, dosis máxima tolerada y eficacia antidepresiva en pacientes con depresión mayor resistente tratados con esketamina intranasal Material y métodos Se incluyen cuatro participantes del protocolo de esketamina intr...

The solute carrier organic anion transporter family member 1B1 (SLCO1B1) encodes the organic anion-transporting polypeptide 1B1 (OATP1B1 protein) that transports statins to liver cells. Common genetic variants in SLCO1B1, such as *5, cause altered systemic exposure to statins and therefore affect statin outcomes, with potential pharmacogenetic appl...

Pharmacogenomics could optimize antipsychotic treatment by preventing adverse drug reactions, improving treatment efficacy or relieving the cost burden on the healthcare system. Here we conducted a systematic review to investigate whether pharmacogenetic testing in individuals undergoing antipsychotic treatment influences clinical or economic outco...

Background:Type 2 Diabetes Mellitus (T2DM) is a genetically linked metabolic disorder with an emerging life-threatening health condition. According to the presently accepted theory, oxidative stress causes impaired glucose tolerance (IGT), β-cell dysfunction, insulin resistance (IR), and eventually leads to T2DM.Additionally, it is thought that bot...

This paper explores the transformative impact of computational pharmaceutics, integrating AI, multi-scale modeling, quantum computing, AI-driven drug discovery, and blockchain frameworks. Molecular dynamics simulations provide insights into atomic behaviors crucial for drug design. Quantum computing reduces computational costs for simulating protei...

La tuberculosis (TBC) es una enfermedad infecciosa causada por bacterias del complejo Mycobacterium tuberculosis (MTBC). Mycobacterium tuberculosis y M. bovis son responsables de la mayoría de los casos de TBC en los humanos1 . La TBC ha infectado a la humanidad desde las pri�meras civilizaciones. El descubrimiento del agente causal, M. tuberc...

INTRODUCTION Smoking cessation is the best strategy for reducing tobacco-related morbimortality. The goal of this randomized controlled trial was to test whether using the genetically favorable markers to choose a smoking cessation drug treatment (precision medicine) was superior to using the most effective drug (varenicline) in terms of abstinence...

Introduction Considering conflicting previous reports, we aimed to evaluate whether the common ABCB1 polymorphisms (rs1128503, rs2032582, rs1045642, rs4148738) affected the risk of bleeding in rivaroxaban-treated patients. Materials and methods We report preliminary data from a larger nested case-control study. Consecutive adults started on rivaro...