Nicotine - Science topic

It is increasingly recognized that an important step towards improving overall health is to accurately measure biomarkers of health from the molecular activities prevalent in the oral cavity. We present a general methodology for computationally quantifying the activity of microbial functional pathways using metatranscriptomic data. We describe thei...

Organophosphate poisoning poses a critical threat to public health, often resulting from exposure to pesticides through inhalation, ingestion, or dermal contact. This review delineates the pathophysiology of organophosphate toxicity, characterized by acetylcholinesterase inhibition leading to excessive acetylcholine accumulation and subsequent over...

Objectives The primary objective of this in vitro experiment was an assessment of proliferative capacity, metabolic activity, and potential cellular detriment of human periodontal ligament cells (hPDL) exposed to cigarette smoke (CS), electronic cigarette vapor (eCV), and heated tobacco product aerosol (HTP), or air (control). Materials and method...

Purpose of Review We analyze adolescent substance use trends during and after the COVID-19 pandemic in the context of the major disruptions that it created. Findings Adolescent substance use overall declined during the pandemic and subsequently rebounded to pre-pandemic levels. While overall rates of use decreased during periods of lockdown, rates...

This study aims to assess the association between nicotine replacement therapy (NRT), varenicline, and untreated smoking with the risk of developing eye disorders. We employed a new-user design to investigate the association between NRT use and the incidence of eye disorders by the Taiwan National Health Insurance program. This study included 8416...

Tobacco, a pivotal economic crop in China, faces the challenge of securing high-quality raw materials for its industry due to unbalanced and inefficient nitrogen (N) application. To assess the impact of fertilizer management and soil factors on the yield and quality of flue-cured tobacco (FCT), a meta-analysis was conducted across 82 peer-reviewed...

Alzheimer’s disease (AD) stands as the most prevalent form of dementia affecting elderly individuals and ranks as the sixth leading cause of death globally. The pathological hallmarks of AD involve the formation of beta-amyloid plaques and neurofibrillary tangles in the brains of affected individuals, contributing to progressive brain degradation....

Objective. Nicotine has major side effects on human health through numerous mechanisms, one of which is the alteration of the immune system and its genetic components. Such alteration can be a predisposing factor for autoimmune diseases such as spondyloarthritis (SpA) and rheumatoid arthritis (RA). This review aims to shed light on the effects of n...

Background and aims In Finland, nicotine pouches entered the national market abruptly in 2023, following a change in April 2023 from medicinal product classification into less regulated tobacco surrogate status. This study aimed to measure adolescent nicotine pouch use and associated characteristics. Design and setting A cross-sectional, nationwid...

Purpose To evaluate which factors exert a predictive value for not reaching the minimal clinically important difference (MCID) in patients who underwent a tailored operative treatment for recurrent lateral patellar dislocation (RLPD). Methods A total of 237 patients (male/female 71/166; 22.4 ± 6.8 years) were included. The Banff Patellofemoral Ins...

Background The HARMONY study is a multicentre, randomised, single-blinded parallel group trial. It will compare the effectiveness of a 12-week course of liquid nicotine delivered via vapourised nicotine products (VNPs) to best practice nicotine replacement therapy (NRT) for smoking cessation in individuals receiving opiate agonist treatment (OAT)....

Cotinine, the primary metabolite of nicotine in the human body, is an emerging pollutant in aquatic environments. It causes environmental problems and is harmful to the health of humans and other mammals; however, the mechanisms of its biodegradation have been elucidated incompletely. In this study, a novel Gram-negative strain that could degrade a...

INTRODUCTION Motivations for using electronic nicotine delivery systems (ENDS) include quitting or reducing cigarette smoking, flavor, and addiction. This study examines whether the primary reason for continued ENDS usage changes over time, and its association with device and liquid characteristics. METHODS Data are from a longitudinal cohort stud...

Nicotine is one of the main pollutants in cigarette smoke that trapped in the filter. Nicotine leakage from cigarette butts is one of the concerns associated with this hazardous waste. In this study, the concentration of nicotine leaked from cigarette butts into the urban environment was investigated under the influence of three parameters includin...

Anticholinergic (AC) drugs, a medication class that acts by blocking nicotinic and muscarinic acetylcholine receptors, were first utilized for therapeutic purposes in the mid-19th century. Initial applications were as symptomatic therapy for Parkinson disease (PD), a practice continuing to the present. Initially, the AC drugs used were naturally-oc...

The emerging concern about chemicals in electronic cigarettes, even those without nicotine, demands the development of advanced criteria for their exposure and risk assessment. This study aims to highlight the sensitivity of lung nuclear receptors (NRs) to electronic cigarette e-liquids, independent of nicotine presence, and the influence of the se...

Purpose Loneliness is a risk factor for mental and physical disorders. Rapid individualization, with increasing associated social burden, is a contributing factor to loneliness among Koreans. This study aimed to investigate the relationship between loneliness and mental disorders, as well as to determine whether long-term loneliness is a factor pre...

Introduction Smoking during pregnancy is harmful to maternal and child health. Vaping is used for smoking cessation but evidence on health effects during pregnancy is scarce. We conducted a systematic review of health outcomes of vaping during pregnancy. Methods We searched six databases for maternal/fetal/infant outcomes and vaping, including qua...

Cigarette smoking presents a significant global health challenge, with approximately 8 million deaths attributed annually to tobacco use. The intricate chemical composition of cigarettes, containing over 5,000 harmful substances like nicotine and tar, disrupts cellular functions, fostering chronic inflammation and immune dysregulation. This not onl...

E-cigarettes are gaining increasing popularity worldwide. The World Health Organization (WHO) estimates that there are nearly one billion (984 million) smokers globally, accounting for approximately one-fifth of the adult population. The use of e-cigarettes in Southeast Asian countries has also seen a rise since 2015, although at a slower pace comp...

The use of electronic nicotine delivery systems (ENDS) has increased in recent years, particularly among young people. The association between mental health disorders and conventional cigarettes is well established. However, information on ENDS use and mental health is still emerging. This study i) determines the frequency of depression, anxiety an...

Introduction Smoking cessation is an essential, but often overlooked aspect of diabetes management. Despite the need for tailored smoking cessation support for individuals with diabetes, evidence of effective interventions for this cohort is limited. Additionally, individuals with diabetes do not easily adopt such interventions, resulting in low up...

Development of low temperature catalytic pyrolysis technology for heated tobacco sheets is expected to increase the aroma of heated tobacco products and improve their overall smoking quality. In this study, the low temperature pyrolysis performances of heated tobacco sheets catalyzed by various anionic sodium salts were investigated using TG-DTG, P...

A practical and convenient method for synthesizing nicotinic acid and nicotinamide with the trifluoromethoxy group in position 5 of the ring has been developed. A series of related compounds, for example, nicotinic aldehyde and nicotinic alcohol, have been synthesized. It has been shown that 3-bromo-5-trifluoromethoxypyridine is a convenient and ef...

The leaves of Nicotiana glauca (Solanaceae) plant, are known for its major cause of health concern. This study investigated the antioxidant activity and polyphenols composition of aerial parts of N.glauca collected from its wild habitat in Jordan, using Methanol-Conventional (MC) and deep eutectic solvents (DESs) extraction methods in addition to n...

The C3-symmetry ionic polymer PPyTri has been designed with multi-walled carbon nanotubes (MWCNTs) or graphene nanoplatelets (GNPs) and studied as an ultrasensitive electrochemical sensor for trace Hg(II) detection. The synthesis approach incorporated attaching three pyridinium cationic components with chloride anions to the triazine core. The prec...

Background Youth vaping is a serious public health concern, being more prevalent than any other tobacco use. To inform cessation interventions, we explored what adolescents perceive as their reasons for quitting and strategies to help them quit. Method Semi-structured interviews were conducted with a convenience sample of 11 adolescents reporting...

Background and aims Smokers typically have a lower body mass index (BMI) than non‐smokers, while smoking cessation is associated with weight gain. In pre‐clinical research, nicotine in tobacco smoking suppresses appetite and influences subsequent eating behaviour; however, this relationship is unclear in humans. This study measured the associations...

The European Union (EU) aims for a tobacco use prevalence of less than 5% by 2040 with its Tobacco-Free Generation goal, aligning with the tobacco endgame approach. In the Joint Action on Tobacco Control 2 (JATC-2) -project, we examined adopted and planned endgame goals and measures as well as preparedness to counter tobacco industry interference i...

Objective Describe the screening, referral, and treatment delivery associated with an opt-out tobacco treatment program (TTP) implemented in six hospitals varying in size, rurality and patient populations. Methods Between March 6, 2021 and December 17, 2021, adult patients (≥ 18 years) admitted to six hospitals affiliated with the Medical Universi...

Organophosphate poisoning poses a critical threat to public health, often resulting from exposure to pesticides through inhalation, ingestion, or dermal contact. This review delineates the pathophysiology of organophosphate toxicity, characterized by acetylcholinesterase inhibition leading to excessive acetylcholine accumulation and subsequent over...

Nicotiana Tabacum; the annual herb; known as Tobacco from the Solanaceae family was known for its alkaloids and especially nicotine (NCT) content; smoking products, insecticides, anthelminthic activity and clinically proven therapeutics are examples of its uses. Herein two different methods were applied in an attempt to quantify the total alkaloids...

People with psychosis exhibit thalamo-cortical hyperconnectivity and cortico-cortical hypoconnectivity with sensory networks, however, it remains unclear if this applies to all sensory networks, whether it arises from other illness factors, or whether such differences could form the basis of a viable biomarker. To address the foregoing, we harnesse...

Nicotine (3-(1-methyl-2-pyrrolidinyl)pyridine) is one of the most common addictive substances, causing the trace detection of nicotine to be very necessary. Herein, we designed and prepared a functionalized nanocomposite CS-PAA (NaYF4:19.5%Yb,0.5%Tm@NaYF4-PAA) using a simple method. The nicotine concentration was quantitatively detected through the...

Objectives: Monitoring tobacco use is one of the most important tobacco control interventions recommended by the World Health Organization. This study aimed to assess the prevalence of cigarette smoking, e-cigarette use, and heated tobacco use in a nationwide sample of adults in Poland, as well as to identify factors associated with smoking, e-ciga...

Background and aims Smoking is recognised as an independent risk factor in the development of chronic pancreatitis (CP). Cystic fibrosis transmembrane conductance regulator (CFTR) function and ductal fluid and bicarbonate secretion are also known to be impaired in CP, so it is crucial to understand the relationships between smoking, pancreatic duct...

Abstract Neonicotinoids form a class of insecticides that are chemically related to nicotine and are widely used in crop protection. They have adverse effects on the neuronal nicotinic acetylcholine receptors (nAChRs). One of the neonicotinoids approved for control of the invasive pest Drosophila suzukii is acetamiprid. Despite concerns regarding i...

Background: Smoking cigarettes is a cause of serious diseases in smokers, including cardiovascular disease. Through a pathway of endothelial dysfunction, lipid infiltration, macrophage recruitment and vascular remodeling, atherosclerosis is fundamental in the development of most cardiovascular diseases. There is an increasing number of next-generat...

U.S. Veterans and people living with HIV (PWH) experience higher rates of unhealthy alcohol and tobacco/nicotine use than non-Veterans and people without HIV (PWoH). Both groups are susceptible to adverse health outcomes associated with alcohol and tobacco/nicotine use. We explored awareness of alcohol- and tobacco/nicotine-related cancer and immun...

Introduction: Maternal smoking impacts the health of both the mother and the baby. During gestation, nicotine can pass through the maternal-fetal blood interface in the placenta, accumulating in the fetal circulation and amniotic fluid. Because nicotine is a teratogenic agent, it can affect the development of the structures and functions in the bra...

Lung cancer (LC) represents the leading cause of global cancer deaths, with cigarette smoking being considered a major risk factor. Nicotine is a major hazardous compound in cigarette smoke (CS), which stimulates LC progression and non-small cell lung cancer (NSCLC) specifically through activation of the nicotinic acetylcholine receptor (α7nAChR)-m...

Resistance to traditional treatment methods is still a major obstacle in modern psychiatry. As a result, several studies are currently being conducted to find effective alternatives to traditional therapies. One of these alternatives is psilocybin, a psychedelic substance that has been tested in clinical trials as an adjunct to psychotherapy. These...

Background The tobacco industry has a history of using language to downplay the harms associated with cigarettes and mislead consumers and policymakers. Emerging evidence suggests similar tactics are being used in the context of e-cigarettes; however, exploration of the impact of product name on attitudes towards e-cigarettes and susceptibility to...

Research of historical tobacco changes and continuation in current practices has led to recommendations after thoughtful consideration by the Pawnee Nation Agricultural Committee and the Chiefs' Council. Preparation of a native tobacco mixture taught to the author by Boy Chief is explained. Traditionalists recently allowed the use of a native tobac...

Background E-cigarette use represents a contemporary mode of nicotine product use that may be changing the risk profile of participating adolescents. Understanding differences in sociodemographic characteristics of adolescents engaging in contemporary e-cigarette use and traditional cigarette use is important for effectively developing and targetin...

Globally, there are around 1.3 billion cigarette consumers, indicating it to be the second highest risk factor for early death and morbidity. Meanwhile, psychological therapy offers tools based on its different models and techniques, which can contribute to smoking cessation. In this context, this study gathers scientific evidence to identify psych...

One of the biggest problems in the treatment of idiopathic Parkinson’s disease is the lack of new drugs that slow its progression. L-Dopa remains the star drug in the treatment of this disease, although it induces severe side effects. The failure of clinical studies with new drugs depends on the use of preclinical models based on neurotoxins that d...

The use of electronic cigarettes, commonly known as vaping, has raised concerns due to the absence of a defined limit on nicotine dosage, in contrast to traditional cigarettes that come in packs of 20 units. This difference in the form of consumption can lead to a higher risk of excessive nicotine intake. Vaping devices allow for continuous use wit...

Background Electronic nicotine delivery systems (ENDS) offer a substantial harm reduction opportunity for adults who smoke and are unlikely to quit. However, a major concern about ENDS is their use by non-smoking youth, and particularly whether ENDS are acting as a “gateway” that leads youth to later start smoking cigarettes. However, evidence for...

Objective To document tobacco industry strategies to influence regulation of new and emerging tobacco and nicotine products (NETNPs) in Latin America and the Caribbean. Methods We analyzed industry websites, advocacy reports, news media and government documents related to NETNPs, focusing on electronic cigarettes and heated tobacco products. We al...

Correction for ‘UHPLC-MS/MS combined with microdialysis for simultaneous determination of nicotine and neurotransmitter metabolites in the rat hippocampal brain region: application to pharmacokinetic and pharmacodynamic study’ by Mingyu Zhu et al. , Anal. Methods , 2024, https://doi.org/10.1039/d4ay00522h.

Rationale Flavors can alter the orosensory properties of tobacco products. Specifically, flavors can serve as an oral cue for smokeless tobacco products. Objectives We aimed to investigate the impact of oral vanillin, the principal chemical of vanilla flavor in tobacco products, on nicotine’s taste, and nicotine choice, intake, and seeking behavio...

Objectives Risk factors for non-syndromic orofacial cleft (NSOFCs) include genetic profile and environmental exposure to medication and illnesses during pregnancy. We assessed the association between the COVID-19 vaccination and the incidence of NSOFC across five Middle Eastern countries. Materials and methods This multi-country, hospital-based, c...

Despite the high tobacco use rates (~80%) and tobacco-related cancers being the second leading cause of death among people experiencing homelessness within the United States, these individuals rarely receive tobacco use treatment from homeless-serving agencies (HSAs). This qualitative study explored the enablers and inhibitors of implementing an ev...

Electronic cigarettes (vape) are actively used, and their use is growing globally. With e-cigarettes, users may get their recommended nicotine intake without burning tobacco. Research indicates that, compared to traditional cigarettes, electronic cigarettes offer a more effective nicotine delivery system and have fewer adverse effects on oral and g...

The alpha7 neuronal nicotinic receptor (alpha7-nAChR) gene, CHRNA7, is widely expressed within the brain and at the periphery. It plays various important roles in cognition and immune functions. Decreased expression of alpha7-nAChR has been associated with Alzheimer disease (AD) triggered by the accumulation of the 42-amino acid beta-amyloid peptid...

Objective: Cannabis is frequently co-used with tobacco/nicotine products, especially among young adults. Little is known about the effects of this co-use on cannabis cessation outcomes. Within a sample of young adults using cannabis frequently (current use of ≥5 days/week in the past 3 months), this study aimed to (a) document sources of exposure t...

The escalating prevalence of psychoactive substance use (Pa SU) presents a significant concern in the African context, particularly among schooling adolescents, leading to potential physical and mental health complications, making substance use a giant monster for every developing society. To address this, the study focused on determining the preva...

Objective To examine whether the real-world effectiveness of popular smoking cessation aids differs between users with and without a history of mental health conditions. Design Nationally-representative cross-sectional survey conducted monthly between 2016–17 and 2020–23. Setting England. Participants 5,593 adults (2,524 with a history of ≥1 men...

Background Reducing cigarette addictiveness has the potential to avert millions of yearly tobacco-related deaths worldwide. Substantially reducing nicotine in cigarettes decreases cigarette consumption, but no large clinical trial has determined the effects of reduced-nicotine cigarettes when other nicotine-containing products are available. The ai...

Achieving high follow-up rates after smoking cessation interventions (SCIs) is a general challenge. The aim of this study was to identify preferences among patients and therapists for improving follow-up rates and to assess smoking status at 6 months among patients lost to follow-up. From the Danish STOPbase for Tobacco and Nicotine, which collects...

A better understanding of nicotine neurobiology is needed to reduce or prevent chronic addiction, ameliorate the detrimental effects of nicotine withdrawal, and increase successful cessation of use. Nicotine binds and activates two astrocyte-expressed nicotinic acetylcholine receptors (nAChRs), α4β2 and α7. We recently found that Protein kinase B-β...

Following the interesting publication "Analysis of the epidemiology, coexisting skin diseases, and variables affecting seborrheic dermatitis severity", the author concluded that "disease severity was higher in smokers". I observed the same correlation while studying my familial dermatitis which resembles seborrheic dermatitis since 1978. In all pat...

Introduction More brands are using tobacco-free nicotine (TFN) in electronic cigarettes (e-cigarettes) and these products are becoming increasingly popular. The term TFN and claims about its properties can mislead consumers about the harms and addictiveness of TFN e-cigarettes, which may increase initiation of these products among non-smokers or in...

Since their introduction to the US market in 2016, oral nicotine pouches have grown in popularity. These small fiber pouches of an appealing taste deliver nicotine to the narrow space between the gum and the lip, precisely at the interface of the mucosa of the vestibulum oris and the oral moisture derived from saliva. This delivery mechanism leads...

Medline, опубликованных с 1970 по 2021 г., осуществлявшийся с помощью ключевых терминов MeSH "bipolar disorder" и "smoking" либо "nicotine" или "tobacco". Результаты поиска дополнены работами, изученными в ходе анализа списков литературы найденных исследований и печатных рукописей. Результаты. Распространенность курения на протяжении жизни, а также...

People living with HIV and those diagnosed with alcohol use disorders (AUD) relative to healthy individuals commonly have low levels of serum albumin, substantiated as an independent predictor of cardiovascular events. White matter hyperintensities (WMH)—a neuroimaging feature of cerebral small vessel disease—are also related to cardiovascular dise...

Introduction Menthol cigarettes are disproportionately marketed and advertised in the commercial tobacco retail environment in Black communities across the United States, contributing to menthol cigarette-related disparities and lower likelihood of successful quitting among Black people who smoke. Policies restricting retail sales of menthol cigare...

In 1987, the World Health Organization (WHO) declared May 31st as World No Tobacco Day to address the tobacco epidemic and deaths due to smoking. In 2017, WHO stated that the tobacco industry is a major contributor to the global pollution crisis, impacting the health and well-being of the worldwide community. In line with WHO's goals, the Malaysian...

INTRODUCTION Electronic cigarettes (e-cigarettes) have emerged as a new paradigm in nicotine delivery systems. Although they are marketed as safer alternatives to tobacco, public perceptions of their safety and utility vary widely. This study aims to understand the percentage of use, factors associated, perceptions, and attitudes about e-cigarettes...

Introduction The commercial tobacco industry has long targeted Black communities by making menthol cigarettes not only appealing but affordable through marketing, advertising, and pricing strategies, particularly in the retail environment. Policies that focus on restricting the sale of menthol cigarettes have the potential to significantly reduce t...

Transcriptome-wide association studies (TWAS) have provided valuable insight in identifying genes that may impact cigarette smoking. Most of previous studies, however, mainly focused on European ancestry. Limited TWAS studies have been conducted across multiple ancestries to explore genes that may impact smoking behaviors. In this study, we used ci...

Background: Electronic nicotine delivery systems (ENDS) have gained popularity in the United States among adults and adolescents for social use and as a smoking cessation tool. The increase of ENDS use leads to concerns about their impact on public health. In the United States, ENDS are readily available for purchase and pose risks. Community pharm...

Tobacco dependence is characterized by decision-making impairments, which may increase the risk of smoking relapse by lowering the capacity to resist the immediate gratification of nicotine consumption. Because controlling one’s desires for immediate rewards is experienced as effortful, aversion to effortful control processes may also influence the...

Nicotine flux, the rate of electronic nicotine delivery system (ENDS) nicotine emission, is important in determining ENDS abuse liability. However, flux does not account for user behavior, including puff duration. Along with nicotine flux, puff duration limits the dose of nicotine that can be inhaled. Controlling both flux and puff duration allows...

Moyamoya disease (MMD) is a rare stenoocclusive cerebral vasculopathy often treated by neurosurgical revascularization using extracranial-intracranial bypasses to prevent ischemic or hemorrhagic events. Little is known about the vascular risk profile of adult MMD patients compared to the general population. We therefore analyzed 133 adult MMD patie...

Dopamine release plays an important role in regulating neuronal behaviors behind drug addiction and abuse. Plant alkaloids and nicotine salts administrations have been reported to exert significant effects on dopamine release in human and animal brains. However, in vivo detection of dopamine in the brain is challenging and mostly invasive, which gr...

Australia prohibits the sale of nicotine-vaping products unless prescribed by medical practitioners. Significant policy reforms were announced on the 28th of November 2023 including a ban on single-use disposable vapes with and without nicotine, and the removal of the personal importation scheme. Despite stringent regulations, loopholes exist such...

Cesarean section (CS) delivery involves surgically delivering the fetus through an incision in the abdominal and uterine walls. Attention to wound care is essential to prevent infections, a common impediment to CS wound healing, with infection rates significantly higher compared to vaginal delivery. Several factors, including age, nutrition, mobili...

Background Prevalence of youth nicotine vaping has increased, heightening concerns around negative health effects. This study aimed to compare self-reported respiratory symptoms among youth by vaping behaviours. Methods Participants (n = 39,214) aged 16–19 from the 2020 and 2021 International Tobacco Control Policy Evaluation Project (ITC) Youth T...

To investigate the pleiotropic mechanisms linking brain structure and function to alcohol drinking and tobacco smoking, we integrated genome-wide data generated by the GWAS and Sequencing Consortium of Alcohol and Nicotine use (GSCAN; up to 805,431 participants) with information related to 3,935 brain imaging-derived phenotypes (IDPs) available fro...

Objective This study aimed to determine nicotine's impact on receptor‐mediated cyclic adenosine monophosphate (cAMP) synthesis in vascular smooth muscle (VSM). We hypothesize that nicotine impairs β adrenergic–mediated cAMP signaling in VSM, leading to altered vascular reactivity. Methods The effects of nicotine on cAMP signaling and vascular func...

Children and youths diagnosed with FASD may experience a range of adverse health and social outcomes. This cross-sectional study investigated the characteristics and outcomes of children and youths diagnosed with FASD between 2015 and 2018 at the Sunny Hill Centre in British Columbia, Canada and examined the relationships between prenatal substance...

Introduction Sleeping disorders is a high prevalent disorder, and although previous research has suggested a link between smoking and sleep disorders, there is a lack of large-scale, nationally representative studies examining this association across multiple sleep outcomes and exploring dose-response relationships. Methods This study used data fr...

This presentation highlights the importance of integrating pharmacological, behavioral, and policy interventions for effective smoking cessation. In addition, staying updated, adapting cessation strategies and individual plus collective commitment are essential. Indeed, a simple yet effective approach is picking a strategy (eg nicotine replacement...