Ziqian Xu's research while affiliated with First Affiliated Hospital of China Medical University and other places
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Publications (15)
Anoikis is considered strongly associated with a biological procession of tumors. Herein, we utilized anoikis-related genes (ARGs) to predict the prognosis and immunotherapeutic efficacy for skin cutaneous melanoma (SKCM). RNA-seq data were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. After dividing patients into nov...
Background
Chromatin regulators (CRs) serve as indispensable factors in tumor biological processes by influencing tumorigenesis and the immune microenvironment and have been identified in head and neck squamous cell carcinoma (HNSCC). Hence, CR-related genes (CRRGs) are considered potential biomarkers for predicting prognosis and immune infiltratio...
Disulfidptosis has been reported as a novel cell death process, suggesting a therapeutic strategy for cancer treatment. Herein, we constructed a multiomics data analysis to reveal the effects of disulfidptosis in tumors. Data for 33 kinds of tumors were downloaded from UCSC Xene, and disulfidptosis-related genes (DRGs) were selected from a previous...
Background
5-Methylcytosine (m ⁵ C) methylation is recognized as an mRNA modification that participates in biological progression by regulating related lncRNAs. In this research, we explored the relationship between m ⁵ C-related lncRNAs (mrlncRNAs) and head and neck squamous cell carcinoma (HNSCC) to establish a predictive model.
Methods
RNA sequ...
Objective:
This study aimed to explore the mechanisms of Baishi tablets (BSTs) in the treatment of vitiligo through network pharmacology-based identification and experimental validation.
Methods:
In brief, the compounds and related targets of BST were extracted from the TCMSP database, and disease information was obtained from the OMIM, GeneCard...
Background
Cuproptosis is considered a novel copper-induced cell death model regulated by targeting lipoylated TCA cycle proteins. In this study, we established a novel signature based on cuproptosis-related lncRNAs (crlncRNAs) to predict the prognosis and immune landscape of head and neck squamous cell carcinoma.
Methods
RNA-seq matrix, somatic m...
Background
A large number of autologous melanocytes are required for surgical treatment of depigmentation diseases such as vitiligo. The purpose of this experiment is to explore the application of melanocytes induced by mesenchymal stem cells to clinical treatment. Therefore, we have induced mouse bone marrow mesenchymal stem cells (BMMSCs) into me...
The prognosis of skin cutaneous melanoma (SKCM) remains poor, and patients with SKCM show a poor response to immunotherapy. Thus, we aimed to identify necroptosis-related biomarkers, which can help predict the prognosis of SKCM and improve the effectiveness of precision medicine. Data of SKCM were obtained from The Cancer Genome Atlas (TCGA) and GE...
Background
Cuproptosis is considered a novel copper‐dependent cell death model. In this study, we established a novel scoring system based on 10 cuproptosis‐related genes (CRGs) to predict the prognosis and immune landscape of head and neck squamous cell carcinoma (HNSCC).
Methods
The RNA‐seq data of HNSCC patients were downloaded from the GEO and...
Background
Previous studies have determined that necroptosis‐related genes are potential biomarkers in head and neck squamous cell carcinoma (HNSCC). Herein, we established a novel risk model based on necroptosis‐related lncRNAs (nrlncRNAs) to predict the prognosis of HNSCC patients.
Methods
Transcriptome and related information were obtained from...
Background:
Alopecia areata is a common non-scarring alopecia, mainly manifested as sudden localized patchy alopecia. It is currently believed to be related to autoimmune, genetic, emotional stress, and endocrine factors.
Objective:
The aim of this study was to evaluate the efficacy and safety of the mixed preparation of piperine, capsaicin, and...
Objective
This study aimed to explore the mechanisms of Hippophae fructus oil (HFO) in the treatment of tympanic membrane (TM) perforation through network pharmacology‐based identification.
Methods
The compounds and related targets of HFO were extracted from the TCMSP database, and disease information was obtained from the OMIM, GeneCards, PharmGk...
Ferroptosis is a non-apoptotic regulated cell death process, and much research has indicated that ferroptosis can induce the non-apoptotic death of tumor cells. Ferroptosis-related genes are expected to become a biological target for cancer treatment. However, the regulation of ferroptosis-related genes in skin cutaneous melanoma (SKCM) has not bee...
Vitiligo is a refractory disfiguring skin disease. However, the aetiology and pathogenesis of vitiligo have not been fully defined. Previous studies have shown that exosomes from normal human keratinocytes improve melanogenesis by up-regulating the expression of melanogenesis-related proteins. Several microRNAs (miRNAs) have been demonstrated to be...
Background
Sweet, spicy or greasy food, staying up late, using electronic products for a long time are common bad habits nowadays. Their role in skin diseases has been paid much attention.
Objective
The aim of this study was to investigate whether unhealthy lifestyles would affect the skin sebum content, SC hydration and pH and how do they affect....
Citations
... Head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumor, with an increasing number of diagnosed and dead patients worldwide [1,2]. Patients in the early phase can mostly be treated with radical surgical resection; nevertheless, the survival rate for those in the advanced stage is quite lower than 50% [3,4]. ...
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... Multiple studies suggested that characteristics of the tumor microenvironment play a significant role in influencing tumor biology and the efficacy of systemic therapy [43][44][45][46][47]. Moreover, recent studies have shown that disulfidptosis could regulate immune cell infiltration, immunoflogosis and the response to immunotherapy [48]. Therefore, we next screened effective drugs for ccRCC patients in the high-and low-risk groups. ...
... Head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumor, with an increasing number of diagnosed and dead patients worldwide [1,2]. Patients in the early phase can mostly be treated with radical surgical resection; nevertheless, the survival rate for those in the advanced stage is quite lower than 50% [3,4]. Complex treatment combined with surgical intervention, radiotherapy, chemotherapy and even immunotherapy is essential for patients [5,6]. ...
... A person's self-esteem, body image, and confidence may be affected by the loss of pigmentation, which can cause social isolation, anxiety, and sadness. Since the disorder is apparent, stigmatisation and prejudice may result, particularly in cultures where fair skin is admired [109]. ...
... Head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumor, with an increasing number of diagnosed and dead patients worldwide [1,2]. Patients in the early phase can mostly be treated with radical surgical resection; nevertheless, the survival rate for those in the advanced stage is quite lower than 50% [3,4]. Complex treatment combined with surgical intervention, radiotherapy, chemotherapy and even immunotherapy is essential for patients [5,6]. ...
... With increasing numbers of diagnosed and dead patients, HNSCC appears to be the most common head and neck tumor, with the top six leading incidences [22,23]. For patients diagnosed with HNSCC, reliable biomarkers or scoring systems are essential for predicting patient prognosis and clinical therapeutic response [24][25][26]. Although multiple predictive models have been established based on bioinformatic technologies according to previous studies, more reliable signatures are lacking because the detailed features may vary due to disease onset from different head and neck organs [27][28][29]. ...
... It has been reported that mouse bone marrow mesenchymal stem cells could be successfully induced to melanocytes. In mouse tissue-engineering experiments, the induced melanocytes survived in transplanted tissues successfully and had similar biological functions to normal melanocytes (128). In autologous cellular therapy, adipose-derived stem cells have been reported to generate proliferative melanocyte precursors (129). ...
... Moreover, by modulating the metabolic products of FAM, tumor cells can manipulate the function of immune cells, thereby suppressing immune responses and evading immune surveillance. HNSCC is a molecularly heterogeneous malignancy [15] that has been closely linked to the biological functions of FAM. [14] Despite this knowledge, the precise relationship between genes related to FAM and HNSCC heterogeneity and prognosis remains incompletely understood to date. ...
... Mao et al. compared a mixed preparation of 0.1% curcumin, 0.1% piperine, and 0.03% capsaicin with a 5% minoxidil tincture for their effectiveness in promoting hair growth in patients suffering from alopecia areata [59]. The rationale for combining curcumin with piperine and capsaicin was the following: curcumin has antiinflammatory properties and increases blood circulation [60]; piperine has been reported to increase the bioavailability of curcumin [61]; capsaicin improves blood circulation and has shown beneficial effects in alopecia areata [62]. ...
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... 19 The dysregulation of ferroptosis-related pathways, including disturbances in iron metabolism and lipid peroxidation, may potentially underlie the progression of SKCM and the emergence of therapeutic resistance. 20,21 Targeting dysregulated PCD pathways holds promise for the treatment of SKCM and overcoming therapeutic resistance, representing a significant area of investigation in cancer research. ...
