Zhonggao Xu's research while affiliated with Jilin University and other places

... For GSEA, we examined the enrichment of biological process pathways by utilizing the "c5.go.bp.v7.4.symbols" gene sets sourced from the MSigDB database (23). This allowed us to identify significant associations between CTSS expression and biological processes. ...

... Hyperglycemia triggers mechanisms such as activation of polyol pathway flux and advanced glycation end products (AGEs) formation, which binds to the receptor for advanced glycation end products (RAGE) and leads to the formation of AGE-RAGE complex, which activates NADPH oxidase (NOX) and stimulates ROS production ( Figure 1). The increase in local angiotensin II (Ang II) synthesis mediates other to produce ROS and the activation of protein kinase C/NOX (PKC/NOX) ( Figure 1) [15]. ...

... However, animal sources of polyclonal antibodies may induce anti-antibody actions that inactivate therapeutic antibodies before showing toxin-neutralizing activity. Similarly, natural drugs have been tested in animal models, but not in clinical trials (Liu et al. 2022). Currently, there is no vaccine available for the treatment of STEC infections in humans (Liu et al. 2022). ...

... Ultimately, a satisfactory outcome was achieved after 21 mo of follow-up. The related English literature reported previously is shown in Tables 2 and 3 [9][10][11][12][13]. Thirteen cases (excluding the present case) have been reported in the English literature, with six cases of amyloid A amyloidosis, one case of apolipoprotein A-1 amyloidosis, four cases of leukocyte chemotactic factor 2 amyloidosis, and two cases of AL amyloidosis. ...

... The inverse variance weighting (IVW) method was employed as the primary analytical method, disregarding the intercept term and using the reciprocal of the outcome variance (se squared) as a fitting weight [37]. The weighted median, MR-Egger regression, simple mode, and weighted mode were used as supplementary analysis methods to further improve the credibility and accuracy of the results [38]. To avoid heterogeneity in instrumental variables (IVs), we used Cochran's Q test, where p > 0.05 indicated no significant heterogeneity [39]. ...

... To identify the differential expression of each cathepsin between IgAN patients and controls, we utilized the R limma package (20). This allowed us to determine which cathepsins showed significant differences in expression between the two groups. ...

... Roxadustat was firstly approved in China in 2018 for treatment of anemia in CKD patients based on the results of a pivotal phase 3 clinical trial [3]. Clinical trials of HIF-PHI have shown that these agents could ameliorate functional iron deficiency and increase Hb levels in CKD patients with anemia [11]. It has been suggested that HIF-PHI is also effective in patients with ESA hyporesponsiveness, such as high-level inflammation and secondary hyperparathyroidism [12]. ...

... The enrichment analysis was conducted using 183 core targets. The betweenness centrality, closeness centrality, and degree centrality of those core targets were all higher than the median (Figure 2A) [79]. The associations among the 183 nodes were plotted by STRING 12.0 ( Figure 2B) [77]. ...

... Previous studies have reported that the presence of microscopic hematuria and/or persistent proteinuria, IgA, and IgA/ C3 are useful for distinguishing IgA nephropathy from other kidney diseases 7,8 . Other research using multivariate logistic regression suggested that age, IgA/C3, albumin, IgA, IgG, eGFR, and the presence of hematuria are independent predictive variables for IgAN 33 . The key predictor variables identified in our study are in line with previous related studies. ...

... TIGIT displays a scarce expression within a limited population of Nc-Mono cells ( Figure 4A), while decreased expression of TIGIT on CD14 + monocytes correlates with clinical features and laboratory parameters of patients with primary Sjögren's syndrome (19). Furthermore, we observed that co-inhibitory molecules and exhaustion (CD272, LAG-3/CD223, and TIM-3) were not differently expressed on three monocyte subsets under normal physiological conditions ( Figures 4A, C), although increased Tim-3 + monocytes/macrophages are associated with disease severity in patients with IgA nephropathy (30). Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13 (21), whereas CXCR5 is upregulated in Ly6C low inflammatory monocyte cells from all mice, presenting antiinflammatory/atherogenic features (31). ...