Zhishan Ding's research while affiliated with Zhejiang Chinese Medical University and other places

... It bolsters the intestinal barrier by promoting the expression of tight junction proteins, which, in turn, curtails the infiltration of deleterious substances and pathogens. The observed shifts in these key genera underscore the potential of SCFA metabolites, like butyric acid, to be synthesized via the fermentation of dandelion root polysaccharides [29]. This process indirectly activates the Nrf2 pathway, thereby fortifying intestinal antioxidant defenses, barrier integrity, and immune modulation. ...

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Integrated Microbiome-Metabolomics Analysis Reveals the Potential Mechanism of Dandelion Root Polysaccharides to Ameliorate Ulcerative Colitis

... Acrylamide (ACR, C 3 H 5 NO) in its monomeric reactive form is not only a carcinogen [1,2], but also a neurotoxin [3][4][5][6] that due to its high solubility in water and lipids [7] can cross all biological barriers, including the blood-brain barrier and placenta [8,9]. Incidentally, high amounts of ACR are produced in the Maillard reaction that occurs during frying and baking [10][11][12]; hence they are present in breakfast cereals, potato and tortilla chips, crisps, and all types of carbohydrate-rich snacks that are processed at temperatures above 120 • C. It is of great consequence then that these snacks are now being consumed in growing quantities [2,7]. ...

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Dietary acrylamide disrupts the functioning of the biological clock

... Polysaccharide interventions, notably with dandelion root polysaccharides, have been observed to enhance the concentration of n-butyric acid in fecal samples significantly. This increase in butyric acid concentration is instrumental in stabilizing the gut microbiota through the activation of the Nrf2 pathway [28]. It bolsters the intestinal barrier by promoting the expression of tight junction proteins, which, in turn, curtails the infiltration of deleterious substances and pathogens. ...

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Integrated Microbiome-Metabolomics Analysis Reveals the Potential Mechanism of Dandelion Root Polysaccharides to Ameliorate Ulcerative Colitis

... (Shanghai, China). Peptide-labeled proteins were analyzed using an Agilent 1100 high-performance liquid chromatograph and TimsTOF Pro mass spectrometer (Thermo, Bruker, USA) 15 . Chromatographic conditions were set as follows: samples were loaded onto a 25-cm C18 analytical column (RP-C18, IonOpticks) at a flow rate of 300 nL/min, followed by gradient elution. ...

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Integrated proteomics and metabolomics analysis of sclerosis-related proteins and femoral head necrosis following internal fixation of femoral neck fractures

... Their characteristics, including chemical compositions, internal structures, and trace elements, will influence medicinal methods, medicinal efficacies, and remedy-based results. There are more than 80 kinds of medicinal mineral resources, including metals and nonmetals in single-element minerals and compound minerals, which are substances, excipients, or additives in antibacterial, hemostasis, wound healing, and other therapeutic drug applications [9,10]. Hemostatic minerals are distinctive and indispensable components in traditional Chinese medicinal mineral resources. ...

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Clays and Wound Healing

... Since January 2020, China has enforced nonpharmaceutical interventions (NPIs), which include quarantining patients, contact tracing, isolating contacts, limiting travel, canceling large gatherings, observing hand hygiene and wearing masks. Like those of COVID-19, influenza viruses are mainly transmitted through the respiratory tract (12,13). Moreover, NPIs may affect the spread of the influenza virus (14)(15)(16). ...

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The effect of nonpharmaceutical interventions on influenza virus transmission

... Botrytis cinerea SJ300021 was cultivated in potato dextrose agar (PDA; HKM, Guangzhou, China) medium at 25°C for 7 days. Afterward, the harvested spores were filtered with sterile gauze and counted as described in previous studies, 21,22 and the counted spore suspension was stored at 4°C for subsequent dilution. Bacillus velezensis SJ100083 was inoculated in Luria-Bertani (LB; HKM) medium and cultured on a rotary shaker (180 rpm) at 37°C for 3-4 days, followed by centrifugation (12 000 × g, 10 min, 4°C) to obtain the fermentation supernatant. ...

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Isolation, structural characterization and sporicidal properties of Baelezcin A, a novel cyclic lipopeptide from Bacillus velezensis SJ100083 against gray mold

... and survminer (version 0.4.9) R packages to assess the survival outcomes of different risk groups based on the risk scores obtained from the model (18). K-M curves were used to determine whether the risk model could effectively stratify patients into distinct survival groups. ...

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Disulfidptosis‑related lncRNA prognosis model to predict survival therapeutic response prediction in lung adenocarcinoma

... Historical records indicate that the roots of T. hemsleyanum have been used to treat high fever, pneumonia, and venomous snake or insect bites in children [11,13]. Modern pharmacological studies have also demonstrated various beneficial effects of T. hemsleyanum, including anti-inflammatory, antibacterial, antiviral, hypoglycemic, immunomodulatory, and antineoplastic effects [12,[14][15][16][17]. T. hemsleyanum is often used as an ingredient in Chinese patent medicines for various conditions. ...

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Kaempferol 3-O-Rutinoside, a Flavone Derived from Tetrastigma hemsleyanum Diels et Gilg, Reduces Body Temperature through Accelerating the Elimination of IL-6 and TNF-α in a Mouse Fever Model

... It induces lipid peroxidation in cardiac tissue and causes cardiac hypertrophy by the oxidation of lipid components [24]. Moreover, the increased activation of NF-κB stimulated by PM 2.5 reduces the antioxidant activity of SOD and GSH, increasing the production of lipid peroxides [25]. As a result, PM 2.5 exposure might cause damage to the antioxidant system associated with the development and progression of heart disease, such as cardiac hypertrophy [26]. ...

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Powdered green tea improved particulate matter (PM)2.5 exposure-induced cardiac cytotoxicity via TLR pathway in BALB/c mice