Zhiming Zhou's research while affiliated with Shenzhen Center for Disease Control and Prevention and other places
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Publications (4)
Background:
Smoking is a risk factor for many human diseases. DNA methylation has been related to smoking, but genome-wide methylation data on smoking in Chinese is limited.
Objectives:
We aimed to investigate epigenome-wide methylation in relation to smoking in Chinese.
Methods:
We measured the methylation levels at >485,000 CpGs of blood leu...
Background
Ageing is related to the risk of many diseases and is affected by genetic, epigenetic, and environmental factors. Exposure to the ubiquitous pollutant polycyclic aromatic hydrocarbons (PAHs) is known to cause health damage, but the relation between such exposure with methylation ageing has not been studied. We undertook an association an...
Citations
... The sub-network graph contains five seeds (S100A8, S100A9, HNRNPDL, SRSF5, HNRNPUL1), among which calprotectin proteins (S100A8 and S100A9) are presented as neighbor seeds that are highlighted in all ten enriched GO terms Rajalingam and Ganjiwale Genomics & Informatics (2024) 22:10 Fig. 6 The gene interaction network of 9 candidate hub genes shows 20 related genes and 331 total links. 18 interacted nodes from the PPI network whose combined score > 0.4 were visualized and candidate hub genes were selected based on their interaction and involvement in both cell and leukocyte activation pathways, a key process in pathology associated with the autoimmune response [48,[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68]. SMAD7 shows its interaction with aflatoxin B1, arsenic, benzo(e)pyrene, bis(4-hydroxyphenyl)sulfone co-treated with fulvestrant, bisphenol A co-treated with fulvestrant, bisphenol A, manganese chloride and methapyrilene resulting in the increased or decreased methylation of the SMAD7 gene and intron affecting its expression [48,51,56,58,69]. ...
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... Even more, epigenetic age appears to reflect aspects of reproductive effort, such as oocyte yield [26], number of pregnancies [27], and the birth weight of offspring [28]. Adverse environments are thought to affect plasticity in life history traits [1], and given that stressful [29] and polluted [30] environments are associated with epigenetic age-acceleration in humans, epigenetic aging presents a potential mechanism linking environmental factors and individual variation in biological aging. However, identifying causal relationships between epigenetic aging and environmental factors is fundamental to understanding the mechanistic role epigenetic processes might play in life history variation. ...
... Shenzhen is one of the forefront cities of China's reform and opening and an important center of global technological innovation and electronics industry. Previous studies reported that the average annual number of OHCA cases in Guangzhou and Shenzhen were around 874 and 658, respectively [29,30]. In general, it is necessary to pay attention to the status of AED facilities in such megacities with massive population. ...
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