Zhijian Ma's research while affiliated with Lanzhou University and other places
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Publications (11)
The acquired resistance of cells to apoptosis is strongly correlated with the development of gastric cancer. Bcl-2-associated athanogene 2 (BAG2) functions as an oncogene in numerous tumours by regulating cell apoptosis. However, its functional, clinical importance and underlying mechanism in gastric cancer (GC) remain unclear. Here, we reported BA...
The crucial role of cancer‐associated fibroblasts (CAFs) in promoting T‐cell exclusion has a significant impact on tumor immune evasion and resistance to immunotherapy. Therefore, enhancing T‐cell infiltration into solid tumors has emerged as a pivotal area of research. We achieved a conventional knockout of Shcbp1 ( Shcbp1 −/− ) through CRISPR/Cas...
Pancreatic cancer (PC) is a highly aggressive and deadly malignancy with limited treatment options and poor prognosis. Identifying new therapeutic targets and developing effective strategies for PC treatment is of utmost importance. Here, we revealed that SHCBP1 is significantly overexpressed in PC and negatively correlated with patient prognosis....
Trastuzumab is the backbone of HER2-directed gastric cancer therapy, but poor patient response due to insufficient cell sensitivity and drug resistance remains a clinical challenge. Here, we report that HER2 is involved in cell mitotic promotion for tumorigenesis by hyperactivating a crucial HER2-SHCBP1-PLK1 axis that drives trastuzumab sensitivity...
Background:
In this study, we aimed to investigate the preoperative serum carcinoembryonic antigen (CEA) in the diagnosis of positive lymph node metastasis (LNM), and to evaluated the relationship between CEA and survival in patients with locally advanced gastric cancer (LAGC).
Methods:
The significance of the preoperative serum CEA level for th...
Background and aim:
Superior mesenteric artery (SMA) first approach was a new improvement for pancreaticoduodenectomy (PD), but there is no evidence whether this approach is advantageous to PD. This meta-analysis aimed to determine the effects of the superior mesenteric artery (SMA) first approach on outcomes of pancreaticoduodenectomy (PD).
Meth...
The primary cilium, a sensory organelle that emanates from the cell surface of most mammalian cell types during growth arrest, has attracted the attention of many researchers over the past decade. Recently, a large number of new findings have assigned novel functions and roles to the primary cilium in signal transduction and related diseases, which...
Introduction: Docetaxel, oxaliplatin, leucovorin, and 5-fluorouracil (FLOT) may improve overall survival (OS) in patients with locally advanced gastric cancer (LAGC); however, evidence for its use as a standard treatment has not been established in China. The aim of this study was to investigate the effectiveness, safety, and feasibility of the FLO...
Gastric neuroendocrine tumors are rarely seen in the gastric tumors, because there are few case reports and the clinical diagnosis rate is low. There is no consensus treatment method in the world. However, with the benefit of esophagogastrodenoscopy and widespread use of proton pump inhibitors, the diagnostic rate of gastric neuroendocrine tumors i...
Objective:
To explore the relationships between the expression level of different galectins and its prognostic value for patients with gastric cancer.
Methods:
The PubMed, EMbase, the Cochrane Library and Web of Science databases were systematically searched. All the eligible studies were included according to the inclusion and exclusion criteri...
Citations
... Increased SHCBP1 predicts poor response to TRA therapy. Theaflavine-3,3′-digallate inhibits SHCBP1-PLK1 interaction, enhancing trastuzumab efficacy in GC patients with HER2 [70]. These outcomes reveal a new strategy to combat GC by targeting the irregular mitotic HER2-SHCBP1-PLK1 axis. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1126139821076480-1645504064934_Q64/Zuo-Yi-Jiao.jpg)
... II III T1 T2 T3 T4 -+ ≤ CEA, one of the most valuable markers for alimentary system tumors, has been widely used in clinical practice. Several studies have successively reported that higher preoperative CEA levels were associated with perigastric LNM in advanced gastric cancer [15,16]. Feng et al. [17] and Miki et al. [18] further indicated that CEA could serve for prognostic evaluation, assessing antitumor drugs, and monitoring local recurrence and metastases in gastric cancer. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1099718235041793-1639204667663_Q64/Xiangyan-Jiang.jpg)
... SMA-first approach in PD has proved its efficacy in minimizing blood loss, resecting completely mesopancreas, achieving R0 resection, and prolonging survival time [1,2]. LPD with SMA-first approach has been increasingly published in specialized centers [3]. ...
... pulsed electromagnetic fields) and mechanic signals (i.e. microgravity) to direct chondrocyte and osteoblast differentiation [28][29][30]. Human bronchial smooth muscle cells project a primary cilium enriched in mechanochemical sensors into the extracellular matrix to initiate migration and wound repair and to mediate cell contraction [12,13]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1142058039414784-1649299263414_Q64/Chen-Wang-419.jpg)
... Determining the most effective chemotherapy regimen for neoadjuvant therapy remains elusive, with practice varying considerably. While the FLOT regimen has shown superior 5-year survival and disease-free survival (DFS) rates compared to previous treatments for gastric cancer and GEJ cancer [11][12][13], it remains unclear whether similar outcomes can be achieved in our patient population. ...
... Gal-1 overexpression in various cancer types has been extensively documented by several studies [36][37][38][39][40]. It directly contributes to various aspects of tumor growth by promoting cell aggregation, adhesion, angiogenesis, migration, invasion, and other factors ( Fig. 1) [41,42]. ...
