Zhi-Jia Chen's research while affiliated with Chung Shan Medical University and other places
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Publications (3)
The Klotho loss-of-function mutation is known to cause accelerated senescence in many organs, but its effects on the cornea have not been published. The present study aims to investigate the effects of the Klotho null mutation on cornea degeneration and to characterize the pathological features. Mouse corneas of Klotho homozygous, heterozygous, and...
Simple Summary
The Klotho gene null mutation has been shown to cause accelerated senescence in many organs. Nevertheless, whether the mutation may cause lacrimal gland dysfunction and degeneration has not been elucidated. This study shows that the Klotho null mutation leads to reduced tear volume with characteristics of lacrimal gland degeneration,...
Klotho is known for its age-suppressing function and has been implicated in sarcopenia pathology. It has recently been proposed that the adenosine A2B receptor plays a crucial role in skeletal muscle energy expenditure. However, the association between Klotho and A2B remains elusive. In this study, Klotho knockout mice aged 10 weeks and wild-type m...
Citations
... Only a few reports on the retina [27][28][29], optic nerve [30], and lens [18], in relation to the Klotho null mutation, have been published, with the underlying pathogenesis mechanisms only specified in a limited manner. Adding to the previously published information, we show that the Klotho null mutation leads to lacrimal gland degeneration with characteristics of histopathological changes, altered neurosecretion, and reduced tear volume [31]. To date, there are no reports regarding the influence of the Klotho null mutation on the cornea. ...
... Andres et al. [171] reported that A 2A R and A 2B R modulate keratinocyte proliferation and suggested a possible role in psoriatic epidermis. Other functions include skeletal muscle degeneration [172], the activation of type 2 immunity [173], erythrocyte function [174] and sickle cell disease [46,175], hypoxia [64], penile erection [176] and priapism [177]. A role for the A 2B R in maintenance of vascular tone [60, 77] and stimulation of epithelial ciliary motility and clearance [178] has also been suggested. ...
