Zheng-Yun Zhang's research while affiliated with Shanghai Jiao Tong University and other places
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Publications (37)
Liver metastasis stands as the primary contributor to mortality among patients diagnosed with colorectal cancer (CRC). Neutrophil extracellular traps (NETs) emerge as pivotal players in the progression and metastasis of cancer, showcasing promise as prognostic biomarkers. Our objective is to formulate a predictive model grounded in genes associated...
Background: Cholangiocarcinoma is characterized by significant cellular heterogeneity and complex intercellular communication, which contribute to its progression and therapeutic resistance. Therefore, unraveling this complexity is essential for the development of effective treatments.
Methods: We employed single-cell RNA sequencing (scRNA-seq) to...
Autoimmune pancreatitis (AIP) is a fibro-inflammatory disease characterized by inflammation and fibrosis of the pancreas. It is a systemic disease that can affect multiple organs, including the bile ducts, kidneys, lungs, and other organs. However, due to its complex presentation, AIP is often challenging to diagnose, and misdiagnosis with pancreat...
Lipopolysaccharide-induced tumor necrosis factor alpha factor (LITAF) is a transcription factor that activates the transcription of TNF-α and regulates the inflammatory response. LITAF has been found to have potential anti-cancer effects of in several tumors. However, the role of LITAF in colorectal cancer (CRC) remains unclear. Through a comprehen...
F-box and WD repeat domain containing 10 (FBXW10) is a member of the FBXW subgroup that contains the WD40 domain. FBXW10 has been rarely reported in colorectal cancer (CRC) and its mechanism is unclear. To investigate the role of FBXW10 in CRC, we conducted in vitro and in vivo experiments. Through the database and our clinical samples, we found th...
Background:
FBXL8 is a conserved F-box protein, belonging to the ubiquitin ligase complex, which promotes the development and progression of tumours. However, the regulation function and mechanism of FBXL8's involvement in colorectal cancer (CRC) remain unclear.
Methods:
RT-PCR is used to detect gene expression levels. Protein levels were determ...
The differences between Bismuth IIIa and IIIb types of hilar cholangiocarcinoma are unclear. Thus, this study aimed to compare the clinical characteristics of the Bismuth IIIa and IIIb types of hilar cholangiocarcinoma. A case series analysis was designed to explore the clinical and pathological findings and survival of 144 patients with hilar chol...
Background
Nodal status is a vital prognostic factor for ampullary adenocarcinoma. This study was designed to evaluate the clinical significance of the positive nodes in this disease.
Methods
Data from 110 patients who underwent curative pancreatoduodenectomy for ampullary adenocarcinoma between January 2007 and December 2018 were retrospectively...
Background
The risk of HCC is documented to be age-related. The outcomes of young HCC patients on postoperative prognosis are not well understood. The study aims to compare the characteristic differences between adolescent and young (AYA) and non-AYA HCC patients.
Methods
We performed a retrospective analysis of the clinical and pathological findi...
Colorectal cancer (CRC) is a common cancer with poor prognosis. The research was designed to explore the role of PHF20L1 in angiogenesis and liver metastasis in CRC and discuss its molecular mechanism. Expression levels of PHF20L1, HIC1 and PAX2 in CRC tissues collected from CRC patients were detected using qRT-PCR, WB and immunohistochemical stain...
Objective
Tumor recurrence remains the main dilemma after surgical treatment of ampulla of Vater carcinoma. This study was designed to identify the prognostic factors and evaluate the recurrence patterns of ampulla of Vater cancer.
Methods
A total of 286 patients who underwent surgical resection of ampulla of Vater cancer in two medical centers fr...
Background: We hypothesized that Sirtuin 1 (SIRT1) might attenuate the Warburg effect in tumor cells by modulating hypoxia-induced factor-1 alpha (HIF-1α) expression. This study aimed to explore the role and the underlying mechanism of SIRT1 in protecting the mitochondrial functions in hepatocellular carcinoma (HCC) cells.
Methods: Quantitative rea...
Colorectal tumorigenesis is a heterogeneous disease driven by multiple genetic and epigenetic alterations. F-box and WD repeat domain containing 11 (FBXW11) is a member of the F-box protein family that regulates the ubiquitination of key factors associated with tumor growth and aggressiveness. Our study aimed to explore the role of FBXW11 in the de...
Hepatocellular carcinoma (HCC) is a public health problem around the world, with the molecular mechanisms being still incompletely clear. This study was carried out to explore the role and mechanism of long-noncoding RNA (lncRNA) FEZF1-AS1 in HCC progression. RNA sequencing and quantitative real time polymerase chain reaction (qRT- PCR) were applie...
Pancreatic ductal adenocarcinoma (PDAC) is a common type of pancreatic cancer with one of the worst survival rate of all malignancies. Recent studies have identified that immunosuppressive B cells could employ the PD‐1/PD‐L1 pathway to suppress antitumor T cell responses, hence, we examined the expression and function of PD‐L1 in B cells. We found...
Objective
This study aimed at assessing the effects of transcatheter arterial chemoembolisation (TACE) and antiviral therapy on improving the prognosis of patients with hepatocellular carcinoma (HCC) after radical hepatectomy.
Methods
This study reviewed the data of 120 patients with HCC who received either radical hepatectomy alone (control group...
Supplementary materials for supplementary Table 1: patients' demographic data were retrospectively collected from the database. Demographic data were described using medians or frequencies. One-way ANOVA or chi-square test was used for the comparison of different groups. All statistical tests reached statistical significance at P < 0.05.
MicroRNA-542-3p (miR-542-3p) functions as a tumor suppressor in many human cancers, but its biological roles in hepatocellular carcinoma (HCC) remains to be further explored. In our study, we revealed that miR-542-3p was frequently down-expressed in HCC cell lines and tissues using real-time quantitative reverse-transcription PCR (qRT-PCR). Overexp...
Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease with unknown causes. The initiation of PBC is associated with bacterial infections and abnormal immune correlates, such as the presence of self-reactive anti-mitochondrial antibodies and shifted balance of T cell subsets. In particular, the CD4(+)CXCR5(+) folli...
Objective:
This study aimed to determine whether the treatment of a long-acting formulation of octreotide (OCT-LAR) exerted a similar effect on improving the prognosis of patients with portal hypertension compared with placement of transjugular intrahepatic portosystemic shunts (TIPSs).
Methods:
A total of 24 patients with portal hypertension wh...
Statement of significance:
Negatively charged nano-carriers prolonged anti-cancer drugs' blood circulation. However it is difficult to be internalised. Therefore, a negative-to-positive charged micelle surface could improve selectivity for tumour cells and increase uptake chance. In this study, we developed a folate (FA)-conjugated and pH-responsi...
Current treatment of intrahepatic cholangiocarcinoma (ICC) remains ineffective because knowledge of ICC carcinogenesis is unclear. Increasing evidence suggests that microRNAs (miRNAs), including miR-191, play an important role in tumorigenesis; but expression and biological functions of miR-191 in ICC remain to be established. This study investigat...
Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is one of the most common cancers in HBV-endemic regions, with irreversible progression and poor prognosis. HBV-related HCC patients lack effective antiviral/antitumor B cell antibody responses. We hypothesize that dysregulation of PD-1-expressing follicular helper T (Tfh) cell, induced...
Although the combination of cisplatin and gemcitabine (GEM) is considered the standard first-line chemotherapy against unresectable hilar cholangiocarcinoma (HC), its efficacy is discouraging. The present randomized open-label clinical trial aimed to evaluate the efficacy and safety of the GEM plus S-1 (GEM-S-1) combination against unresectable HC....
Heme oxygenase-1 has been identified to protect allograft from ischemia/reperfusion and immunologic rejection. Activity of heme oxygenase-1 is regulated by a guanine-thymine dinucleotide length polymorphism in the heme oxygenase-1 gene promoter. In this study, we aimed to explore the impact of the heme oxygenase-1 gene promoter polymorphism of dono...
Studies investigating the association between hepatitis C virus (HCV) infections and the occurrence of cholangiocarcinoma (CCA), especially intrahepatic cholangiocarcinoma (ICC), have shown inconsistent findings. Although previous meta-analyses referred to HCV and CCA, they mainly focused on ICC rather than CCA or extrahepatic cholangiocarcinoma (E...
Objective:
The influence of surgical approaches on patients with gastric cancer with portal hypertension is unknown. The aim of the study was to investigate the outcomes in such patients who had undergone curative surgery for gastric cancer.
Patients and methods:
The clinical data of 60 patients with portal hypertension undergoing curative surge...
Objective:
Little is known about the role of antiviral therapy for patients with hepatitis B who underwent curative hepatectomy for hepatocellular carcinoma (HCC). The aim of this study was to assess whether antiviral therapy after hepatectomy improves the prognosis of HCC in preoperatively antiviral-free patients.
Materials and methods:
This wa...
We hypothesized that the combination of APACHE II and Model for End-Stage Liver Disease systems would work satisfactorily in patients admitted to intensive care unit after living-donor liver transplant.
Data were retrospectively collected from the database of our surgical team. The study included 38 patients (hepatitis B virus cirrhosis, 47.4%; hep...
Infective factors cause the perpetuation of inflammation as a result of the permanent exposure of the immune system to exogenous or endogenous products of virus or bacteria. Mesenchymal stem cells (MSCs) can be exposed to this infective environment, which may change the characteristics and therapeutic potency of these MSCs. MSCs have the ability to...
It is still uncertain whether total bilirubin per se is a risk factor for osteoporosis in postmenopausal women and no study has so far examined this important issue. This study was designed to assess the sheer effects of total bilirubin on the prevalence of osteoporosis in postmenopausal women without potential liver disease. In the present study,...
Aims:
Gamma glutamyltransferase (GGT) has attracted great interest as a potential novel marker of cardiovascular risk. However, its association with coronary artery calcification (CAC) score-determined coronary artery atherosclerosis is unknown. This study was designed to assess the association of GGT with CAC score.
Methods:
Participants, 311 a...
Serum total bilirubin has been suggested to have the potential anti-inflammatory and antioxidant effects on the vasculature. This study was designed to investigate the association of bilirubin with brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness and cardiovascular disease. Hypertensive male subjects (n = 2,361) were class...
Serum total bilirubin has been suggested to have potential anti-inflammatory and antioxidant effects on the vasculature, acting against plaque formation and subsequent atherosclerosis. This study was designed to assess the association of serum total bilirubin with coronary artery calcification (CAC).
Individuals with higher bilirubin level would be...
The induced expression of heme oxygenase-1 (HO-1) in donor islets improves allograft survival. Cobalt protoporphyrin (CoPP) could significantly enhance the expression of HO-1 mRNA and protein in rat islet safely. Our work was to study how to protect pancreatic islet xenograft by CoPP-induction.
Islet xenografts treated with CoPP-induction and CoPP...
To study the protective effect of islet xenograft and its possible mechanism of high expression of heme oxygenase-1 (HO-1) in donor pancreas islet induced by cobalt protoporphyrin (CoPP).
Male SD rats and C57BL/6 mouse were used as donors and recipients respectively. Donors were divided into 3 groups according to different pretreatment 24 hours bef...
Citations
... Our study presents an analysis of 17 neddylation-related genes, embodying a wide spectrum of biological functions, notably in protein degradation and ubiquitination exemplified by PSMB8, PSMB9, PSMB10, F-box protein 41 (FBXO41), FBXO17, F-box and leucine-rich repeat protein 16 (FBXL16), FBXL8 [49][50][51][52][53][54][55], cell cycle regulation and apoptosis including baculoviral IAP repeat containing 5 (BIRC5), denticleless E3 ubiquitin protein ligase homolog (DTL) [56,57], immune response and inflammation mediated by PSMB8, PSMB9, PSMB10, and ubiquitin D (UBD) [58][59][60][61], as well as DNA repair and genomic stability with a pivotal contribution from DNA damage-binding protein 2 (DDB2) [62]. Additionally, they are instrumental in signal transduction processes, particularly involving WD repeat and SOCS box containing 1 (WSB1) and the ankyrin repeat and SOCS box protein (ASB) protein family [63,64]. ...
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... The existing literature already suggested that the majority of lymph node metastases are found in peripancreatic lymph nodes stations 13 and 17 for AAC, 22,23,25,[27][28][29] dCCA, [30][31][32] and DAC. 33 This study confirmed that most lymph node metastases are located in peripancreatic stations 13 and 17 of all NPPCs. ...
... According to the latest statistics, approximately 50-80% of HCC cases worldwide are caused by HBV infection (10), but 13.8% of cases are in Japan (11). Zhang Z Y et al. reported that most AYA patients had a history of HBV and good liver function (12). The occurrence of non-B-cell non-C-cell HCC in the AYA individuals with a normal liver is extremely rare (13). ...
... In adult kidneys, PAX2 expression is limited to the medullary region as well as after acute kidney injuries, with some evidence suggesting that this re-expression might be involved in sustaining pluripotency and stem cell populations [59]. It was proven recently that PAX2 expression promotes angiogenesis in ovarian and colorectal carcinoma cell lines and also the formation of liver metastasis in colorectal carcinoma, suggesting its important role in oncogenesis [60][61][62]. ...
... Regarding the recurrence presented in our population, 50% is like what is reported in the literature (43.5%, Park; 44.8%, Zhang) [8,15] corroborating the aggressive nature of the disease. We add that the recurrence in our study was similar regardless of the histological subtype, be it pancreatobiliary, or intestinal (P=0.72), ...
... 44 FBXW11, one of the substrate receptors of CUL7, was also reported to promote the proliferation of lymphocytic leukemia cells and the metastasis of colorectal cancer. 45,46 In this study, for the first time, we document the correlation between CUL7 FBXW11 complexes and EGFR-TKI resistant phenotype (Fig. 4j, k). Although we showed CUL7 FBXW11 is the E3 ligase of TET2 in NSCLC, other potential E3 ligase or substrate receptor of TET2 may exist in other cell types, such as immune cells. ...
... Therefore, GCSC is a viable target for anticancer medications that can stop GC from recurring, even though little is known about its possible regulation mechanism. According to a prior study, FEZF1-AS1 targets miR-444 to increase the growth of osteosarcoma and miR-107 to enable the development of pancreatic ductal adenocarcinoma [67]. However, the FEZF1-AS1 miRNA targets in GC have not yet been identified. ...
... While, CD8 + T cells, Th1type CD4 + T cells, and natural killer (NK) cells exhibit anti-tumor activity in PDAC-TME, a strong immunosuppressive niche is established by regulatory T (Treg) cells, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and their associated molecules. The ineffectiveness of immunotherapeutic approaches for treating PDAC is a result of this highly immunosuppressive environment (12). ...
... Several investigations have proposed that miR-542-3p modulates the apoptosis of cancer cells. In this regard, these studies have shown that miR-452-3p modulate the apoptosis level of neoplastic cells via regulating miR-542-3p/surviving [59], circRBM33/miR-542-3p/ HIF-1 [50], TUG1/miR-542-3p/TRIB2 [22], circ-PGAM1/miR-542-3p/PEAK1 [25], and XLOC_005950/miR-542-3p/PFKM [46]. ...
... Qi-Feng Chen et al. reported [38] that TACE should be combined with systemic therapy, such as moleculartargeted therapy, immunotherapy and antiviral therapy. TACE combined with antiviral therapy can significantly improve the survival of HBV-related HCC patients [39][40][41]. Myung Pyo Kim et al. reported [42] that for patients with low viral load (DNA level < 2000 IU/ml) receiving TACE, antiviral therapy was a prognostic factor for two-year survival (HR,0.503,P = 0.022). ...
