Zheng Chen's research while affiliated with Fudan University and other places
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Publications (13)
b> Background: 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-Oxo-ETE) is a metabolite of arachidonic acid shown to promote biological activities in different cell types. Summary: 5-Oxo-ETE is synthesized from the 5-lipoxygenase product 5S-HETE (5S-hydroxy-6,8,11,14-eicosatetraenoic acid) in the presence of the nicotinamide adenine dinucleotide phosphate...
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Introduction:
CD8+CD25+Foxp3+ regulatory T cells (Tregs) play an important role in human's immune tolerance. The study was aimed to assess the influence of budesonide nasal spray on CD8+CD25+Foxp3+ Tregs and to evaluate their cellular functions in neutrophilic chronic rhinosinusitis with nasal polyps (CRSwNPs).
Methods:
Fifteen patients with neu...
Background:
CD8+CD25+fork-head box transcription factor (Foxp3)+ regulatory T cells (CD8+ Tregs) play a role in immune tolerance. However, the role of these cells in allergic rhinitis (AR) has not been elucidated. The study aimed to evaluate influences of CD8+ Tregs on inflammatory conditions in a murine model of AR.
Methods:
A murine model of A...
Background
CD8⁺CD25⁺fork-head box transcription factor (Foxp3)⁺ regulatory T cells (CD8⁺ Tregs) play a role in immune tolerance. However, the role of these cells in allergic rhinitis (AR) has not been elucidated. The study aimed to evaluate influences of CD8⁺ Tregs on inflammatory conditions in a murine model of AR.
Methods
A murine model of AR wa...
Objective:CD8⁺CD25⁺Foxp3⁺regulatory T（Treg） cells are reduced in chronic rhinosinusitis with nasal polyps（CRSwNP）. However, the role of these cells in nasal polyps（NP） has not been fully investigated. The aim of this study was to evaluate the influence of budesonide treatment on these cells and to assess their roles in neutrophilic NP. Method:Eight...
Background:
Neutrophilic chronic rhinosinusitis with nasal polyps (CRSwNP) occur predominantly in Asian subjects. Appropriate treatments for this endotype have not been elucidated. This study aimed to evaluate the efficacy of budesonide nasal spray on neutrophilic CRSwNP.
Materials and methods:
Fifteen neutrophilic CRSwNP patients were included,...
Objectives
CD8⁺(or CD4⁺) CD25⁺fork‐head box transcription factor (Foxp3)⁺ regulatory T cells (CD8⁺ or CD4⁺ Tregs) all play a significant role in immune homeostasis and tolerance. However, the role of CD8⁺ Tregs in allergic rhinitis (AR) have not been clearly elucidated. The present study was aimed to assess the influence of CD8⁺ Tregs on peripheral...
Introduction
Nuocytes play an important role in Type 2 immunity. However, the contribution of ILC2s to allergic rhinitis remains to be clearly elucidated.
Objective
To evaluate the role of nuocytes from mesenteric lymph node on allergic responses in mice.
Methods
After intraperitoneal administration of interleukin IL-25 and IL-33 to wild-type and...
Objective:
Nuocytes are essential in innate type-2 immunity and contribute to the exacerbation of allergic rhinitis (AR). This study aimed to evaluate the intervention of Orai1 on the response of nuocytes from AR mice to interleukin (IL)-33.
Methods:
We established a murine model of AR. Nuocytes were obtained from the mouse nasal-associated lymp...
Objective
Chronic rhinosinusitis (CRS) is a complicated disease with several variants caused by different cellular and molecular mechanisms. The characterization of this heterogeneity supports the definition that the disease consists of many endotypes, such as eosinophilic and neutrophilic CRS, and so on. This study aimed to explore group 2 innate...
Objective:
CD4+ T cells play an important role not only in the induction of allergy but also in allergic inflammation. Group 2 innate lymphoid cells (ILC2s) also mediate type 2 immune responses in allergic rhinitis (AR). However, the relationships between CD4+ T cells and ILC2s in allergic condition are currently not well defined. The study aimed...
Background:
5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent eosinophil chemoattractant and activator that is synthesized not only in inflammatory cells but also in bronchial epithelial cells. The purpose of this study is to clarify whether 5-oxo-ETE can promote the production of eosinophil cation protein (ECP) by eosinophils in nasal...
Citations
... The enzyme 5-HEDH oxidizes 5-HETE to produce 5-Oxo-ETE and is found in eosinophils, neutrophils, as well as airway epithelial cells, airway smooth muscle cells, and keratinocytes [160]. Lin et al. reported that 5-Oxo-ETE, a metabolite synthesized from LTB4 in human neutrophils, acts as a potent chemoattractant for cells with the OXE receptor, including eosinophils and other inflammatory immune cells [161]. The presence of 5-Oxo-ETE has been documented in patients with allergic asthma and rhinitis [162]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1002985576480771-1616141804796_Q64/Fei-Dai-9.jpg)
... [35,36] Finally, flow cytometric analysis of SILP regulatory lymphocyte populations revealed a NP-mediated increase in the count ( Figure 3J), but not in frequency ( Figure 3I), of SILP CD8 + CD25 + FoxP3 + T regs , a non-classical regulatory population of which little is currently known about their contributions in desensitizing food allergy. [37][38][39][40] Similar OVA NP-induced trends in CD4 + and CD8 + T reg frequencies and counts were observed in the spleen, but not in the Peyer's patches or mesenteric lymph nodes ( Figure S5, Supporting Information). ...
... In addition, GC treatment can increase CTLA-4 cells and decrease CD69+ cells in the CD25+ cell population, which results in the expansion of Treg cells [149,150]. Lin et al. investigated the effect of budesonide nasal spray treatment on CD8+ Tregs in patients with CRSwNP and found no increase in the percentage of CD8+ Treg cells in polyp tissues, although TGF-β and its mRNA were upregulated [151]. Edward et al. treated CRSwNP patients with oral prednisone and found an expansion of overlapped Treg cells in nasal polyp tissues via CCL4 chemotaxis without a significant increase in adjacent ethmoid sinus mucosa and PBMCs [152]. ...
... Certain research has indicated that, under chronic stimulation or specific pathological conditions, such as chronic infections or cancer, CD8+ T cells may experience immune exhaustion, characterized by a gradual loss of function and activity in response to sustained stimuli (41). Regulatory CD8+ T cells have inhibitory effects during AR occurrences, impacting inflammatory responses (42)(43)(44). Though not primary participants in allergic reactions, CD8+ T cells may exhibit exhaustion in response to allergens. ...
... Wen et al. [37] suggested that patients with the neutrophilic phenotype, including NCRS and mixed eosinophilic-neutrophilic inflammation in CRS, have a reduced response to glucocorticoid therapy. There is no improvement in the number of neutrophils or the expression of MUC5AC, MUC5B, and MPO after treatment with topical glucocorticoid therapy [89]. In summary, glucocorticoid therapy offers limited benefits in NCRS and mixed eosinophilic-neutrophilic inflammation in CRS. ...
... Clinical studies on treatment are also constantly being carried out, such as Lianhua Qingwen and specific immunotherapy. [61][62][63] Among these, some monoclonal biological products are more popular (Dupilumab, Omalizumab, Mepolizumab, Benralizumab), 64,65 but they are still in the process of further validation and research, and they are expensive and have a longer treatment cycle.Therefore, nasal endoscopy surgery for CRS is still indispensable and serves as the beginning of systematic treatment. The postoperative treatment and care are also important guarantees for promoting inflammation improvement and preventing recurrence. ...
... Currently, the theory of imbalance between type 1 helper T ( 1) and type 2 helper T ( 2) cells is widely accepted [6]. e relationship between the pathogenesis of AR and cytokines has been extensively investigated such as interleukin 4 (IL-4) and interleukin 9 (IL-9) released by 2 cells [7,8], interleukin 5 (IL-5) produced by CD4 + T cells and mast cells [9], interleukin 12 (IL-12) released by antigen-presenting cells (APCs) [10], and tumor necrosis factor-alpha (TNF-α) secreted by macrophages [11]. Additionally, the disorder of the cytokine network is the molecular basis for developing AR [12]. ...
... The results indicated that 5-Oxo-ETE could be formed in epithelial cells of polyp tissues under the condition of oxidative stress. And this mediator could also increase the levels of eosinophil cationic protein in organ cultures derived from nasal polyps [79]. Eosinophilic inflammation is considered to be a major pathologic hallmark of chronic rhinosinusitis with nasal polyps [80]. ...
