Yuqi Fan's research while affiliated with Tianjin University of Traditional Chinese Medicine and other places
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Publications (11)
Ethnopharmacological relevance:
Perilla Folium (PF), is a traditional medicinal material with the homology of medicine and food in China and has been widely used due to its rich nutritional content and medicinal value. The hepatoprotective effects of PF extract include their protection against acute hepatic injury, tert-butylhydroperoxide (t-BHP)...
Perilla frutescens (L.) Britt. is a plant that has been classified as one of the "One Root of Medicine and Food", and it can be used both as medicine and as food. To explore the influence of different varieties and harvest periods on the quality of different medicinal parts of P. frutescens, a comprehensive study on the chemical constituents of P....
Chrysanthemum originates in China and has been cultivated for tea and food utilizations over 2 thousand years. According to differences in origin and processing methods, Chrysanthemum morifolium Ramat. can be categorized into many cultivars. This study aims to investigate the chemical components of chrysanthemum and clarify the similarities and dif...
This paper presents a new high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method with a rapid analysis of 6 min to determine the concentration of galgravin in rat plasma so as to study its pharmacokinetic features and bioavailability in vivo. Schisandrin was selected as the internal standard (IS). After extracting the a...
Periplocin, as one of the components of cardiac glycosides in Cortex Periplocae, exhibited cardiotonic effects. Orally ingesting periplocin in high doses or over prolonged periods would cause serious adverse reactions, especially cardiotoxicity, which limits the applications of periplocin in clinical therapy. It has been reported that panax notogin...
Asarum is a traditional medicine and has been widely used as remedies for inflammatory diseases, toothache, headache, local anesthesia, and aphthous stomatitis in China, Japan, and Korea. Our previous research found that safrole and methyl eugenol were vital compounds that contribute to distinguish the different species and raw Asarum and its proce...
Veratrum nigrum L. is a well-known traditional Chinese medicine with a lot of pharmacological activities including antihypertensive, anticancer, and antifungal effects. In the current experiment, a rapid and sensitive UPLC-MS/MS method that takes only 7 min run time has been established and validated for simultaneous determination of eight bioactiv...
Cancer, the leading cause of death in the world nowadays, is a major public health problem. The therapeutic efficacy of cancer is still unsatisfactory despite the development of various treatments. Traditional Chinese medicine (TCM) formulas are a vital therapeutic strategy and new treatment approach for cancer, as they exhibit prospective antitumo...
Alpha-viniferin is a trimer of resveratrol and has various pharmacological activities including anti-Alzheimer’s disease, anti-tuberculosis, anti-tumor, anti-inflammatory and anti-diabetic. To investigate the pharmacokinetic characteristics and absolute bioavailability of α-viniferin in rats, using naringenin as an internal standard (IS), a rapid H...
Liver diseases are clinically common and present a substantial public health issue. Many of the currently available drugs for the treatment of liver diseases suffer from limitations that include low hepatic distribution, lack of target effects, poor in vivo stability and adverse effects on other organs. Consequently, conventional treatment of hepat...
Cancer is a major public health problem, and is now the world’s leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nano-targeted drug-delivery systems have remarkable advantages and allow the development...
Citations
... Compound 13 presented the [M−H] − ion at m/z 593 and its fragment ions at m/z 503, 473, 383, and 353, indicating two neutral losses of 120 Da (m/z 593 → 473 → 353); thus, it was identified as apigenin-6,8-di-C-hexoside[94,110,116,117]. Compound 33 showing a neutral loss of 120 Da (m/z 431 → 311) did not exhibit a [M−H−2H 2 O] − fragment ion (at m/z 395) typical for flavone-6-C-hexosides; thus, it was suggested to be apigenin-8-C-hexoside[110,131,132]. ...
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... On the other hand, the various stages of TCM production and preparation, such as planting, harvesting, and storage, are also subject to the impact of environmental factors. These stages are critical in determining the final quality and therapeutic potential of TCM products (Fan et al., 2022). Variations in environmental conditions during these phases can induce significant differences in the pharmacokinetic profiles of TCM compounds. ...
... Several bioactive ingredients of P. kadsura have been identified [14]. Among them, galgravin ( Figure 1A) is a tetrahydrofuran lignin [15,[17][18][19][20][21][22][23] exhibiting a neuroprotective effect in primary neuronal cultures [24], a cytotoxic effect in human leukemia tumor cells [19], and the inhibitory effect of excessive bone resorption in mouse bone marrow cells [22]. In addition, galgravin also exhibits an edema-suppressive effect in rats with the carrageenan-induced paw test [25], implying its anti-inflammatory potential. ...
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... However, the discovery of novel anti-MM agents, especially from natural sources is considered a crucial approach to MM treatment. Studies have reported that PP is a natural anti-cancer agent which showed the inhibition of tumor cell proliferation and induction of apoptosis in some cancers through different mechanisms on a cellular level in vitro and in vivo [37,[51][52][53][54]. Clinically, PP has been used for its cardiotonic effects [55]. A study reported clinical observation of 147 cases of chronic congestive heart failure under the treatment of Xiangjiapi mixture (including ingredients mainly PP), which safely showed high efficacy rates [56]. ...
... Essential oils composition has also been reported to be influenced with the light quality in different aromatic plant species, e.g., rosemary [33], Japanese mint [34], thyme, marjoram and oregano [9]. In Asarum essential oils, methyleugenol and eucarvone are the active ingredients [35,36], whereas safrole and myristicin are the toxic ingredients [37,38]. The results, that elemicin, 3,5-dimethoxytoluene and methyleugenol were accumulated in higher quantities in response to light quality V, can be a useful observation. ...
... Cancer is one of the major diseases that threatens human health, and most chemotherapy drugs not only inhibit tumors but also cause significant damage to the human body [61,62]. TCM is highly valued due to its minimal side effects [63,64]. Existing research has shown that C. speciosa polysaccharides (CSPs) have anti-tumor effects. ...
... It is also abundantly present in Astilbe grandis, Caragana chamlagu, Carex baccans, Cayratia trifolia, Dipterocarpus littoralis and other plants (Fuloria et al., 2022). Available literature demonstrates an array of biological activity of α-viniferin which includes anti-diabetic, anti-plasmodial, anti-inflammatory, and anti-cancer activity (Fan et al., 2020;Gonzalez-Sarrias et al., 2011;Lulan et al., 2020;Moriyama et al., 2016), but it has never been assessed for its MAO inhibitory potential. The outcome of this study shouts for an unexplored character of the compound which may hold bright prospects in therapeutics. ...
... Chronic inflammation and injury to the liver can cause it to malfunction, which in turn can lead to cirrhosis or liver failure. One potential strategy for dealing with this complicated condition is the use of theranostic nano vesicles that contain herbal components [134]. Utilisation of nano vesicles, which are vesicular structures on the nanometer scale and usually made of biocompatible components such as lipids or polymers, is central to this novel technique. ...
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... TCM has several anticancer properties, including inhibiting proliferation, regulating immunological response, and inducing apoptosis [23]. These positive aspects of TCM implies that it could be a potential therapeutic strategy for treating cases with a range of malignancies [24,25]. However, the mechanisms of action have not been fully investigated and require further research. ...
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