Yun Peng's research while affiliated with Yangzhou University and other places
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Publications (3)
Background:
Liver iron and fat are often co-deposited, synergistically aggravating the progression of chronic liver disease. Accurate determination of liver iron and fat content is helpful for patient management. To assess the accuracy of hepatic iron/fat decomposition using dual-energy computed tomography (DECT) for simultaneously quantifying hep...
Objectives
To compare diffusion parameters obtained from mono-exponential, bi-exponential, and stretched-exponential diffusion-weighted imaging (DWI) in stratifying non-alcoholic fatty liver disease (NAFLD).Methods
Thirty-two New Zealand rabbits were fed a high-fat/cholesterol or standard diet to obtain different stages of NAFLD before 12 b-values...
Purpose:
To examine the feasibility of MR diffusion kurtosis imaging (DKI) for characterizing nonalcoholic fatty liver disease (NAFLD) and diagnosing nonalcoholic steatohepatitis (NASH).
Methods:
Thirty-two rabbits on high fat diet with different severities of NAFLD were imaged at 3 T MR including diffusion weighted imaging (DWI) and DKI using b...
Citations
... Therefore, valid fat quantification in the presence of iron is necessary. While it is known that fat contents are underestimated in the presence of iron in dualsource CT [16,17], the potential impact of iron on dlCT fat quantification and how to deal with it was not clear, yet. ...
... Diffusionweighted imaging (DWI), including intravoxel incoherent motion (IVIM) DWI, can be used to quantitatively assess parenchymal pathologies such as steatosis and fibrosis in solid abdominal organs [12]. An animal study demonstrated that mono-exponential, bi-exponential, and stretched exponential DWI models offer more reliable parameters for risk stratification of NAFLD and the early detection of borderline NASH, thereby aiding in early disease diagnosis and differentiation [13]. ...
... This was done in order to establish a control group that would correspond to the obtained HFHC-fed model. In the in vivo experiment involving rabbits, a modified version of a previous study was followed [26][27][28] . Male New Zealand white rabbits were administered a specific HFHC diet for a duration of 8 weeks. ...
