Yun Jiao's research while affiliated with Loyola University Maryland and other places
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Publications (11)
Background
It is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic immune changes contribute to posttraumatic neuroinflammation and neurodegeneration. However, how TBI affects bone marrow (BM) hematopoietic stem/progenitor cells chronically and to what extent such c...
Traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function which contribute to posttraumatic neuroinflammation and neurodegeneration. However, how TBI affects bone marrow (BM) hematopoietic stem/progenitor cells chronically and to what extent such changes may negatively impact innate immunity and neurological func...
Traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function which contribute to posttraumatic neuroinflammation and neurodegeneration. However, how TBI affects bone marrow (BM) hematopoietic stem/progenitor cells chronically and to what extent such changes may negatively impact innate immunity and neurological func...
Traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function which contribute to posttraumatic neuroinflammation and neurodegeneration. However, how TBI affects bone marrow (BM) hematopoietic stem/progenitor cells chronically and to what extent such changes may negatively impact innate immunity and neurological func...
Antigen-presenting cells (APCs) are widely studied for treating immune-mediated diseases, and dendritic cells (DCs) are potent APCs that uptake and present antigens (Ags). However, DCs face several challenges that hinder their clinical translation due to their inability to control Ag dosing and low abundance in peripheral blood. B cells are a poten...
Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months old) and demonstrate that in comparison to young mice, one-third of old microglia are AF, characterized by profound changes...
Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins that accumulates in post-mitotic cells with advanced age. Here we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months-old) and demonstrate that in comparison to young mice, one third of old microglia are AF, characterized by profound changes in...
Antigen presenting cells (APCs) have been extensively studied for treating cancers and autoimmune diseases. Dendritic cells (DCs) are potent APCs that uptake and present antigens (Ags) to activate immunity or tolerance. Despite their active use in cellular immunotherapies, DCs face several challenges that hinder clinical translation, such as inabil...
Traumatic brain injury (TBI) is a prevailing cause of disability and death. There are no curative therapies or robust predictors of long-term neurodegenerative disease. Treatment is challenging due to poor understanding of the cellular responses and mechanisms underlying TBI. We linked transcriptional profiling, cytokine profiling, and behavioral s...
Chronic neuroinflammation with sustained microglial activation occurs following severe traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration and neurological deficits. Microglia, the primary innate immune cells in brain, are dependent on colony stimulating factor 1 receptor (CSF1R) signaling for their survival....
Chronic neuroinflammation with sustained microglial activation occurs following moderate-to-severe traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration and neurological deficits. Microglia, the primary innate immune cells in brain, are dependent on colony stimulating factor 1 receptor (CSF1R) signaling for thei...
Citations
... Within the local tissue microenvironment, a deficiency or suppression of effector CD8+ T-cells has been noted and is often accompanied by an uptick in activated CD4+ Th cells (Figure 2). In this context, biomaterials with the capability of enhancing the expansion of CD8+ T-cells could play an important role in ameliorating autoimmune pathologies ( Figure 3): for example, the generation of more CD8+ cyTregs (potent suppressors of activated CD4+ T-cells) in vivo with the delivery of relevant stimulatory biomaterials or ex vivo for the direct delivery of cells as a therapeutic [17,45]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1110106477461505-1641681417088_Q64/Ryan-Pearson-2.jpg)
... Mounting evidence suggests the involvement of brain immune signaling as a key driver of long-term outcome following mTBI [10][11][12][13][14][15][16][17][18][19][20][21]. Brain immune signaling is implicated in several neurodegenerative diseases associated with mTBI, including Alzheimer's disease (AD) [22][23][24] and Parkinson's disease [25][26][27]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1161092814372865-1653837507309_Q64/Rodney-Ritzel.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/947286658002944-1602862147499_Q64/Zhuofan-Lei.jpg)
... Mounting evidence suggests the involvement of brain immune signaling as a key driver of long-term outcome following mTBI [10][11][12][13][14][15][16][17][18][19][20][21]. Brain immune signaling is implicated in several neurodegenerative diseases associated with mTBI, including Alzheimer's disease (AD) [22][23][24] and Parkinson's disease [25][26][27]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/602828498300928-1520736922271_Q64/Rebecca-Henry-10.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/970109237620754-1608303474676_Q64/Sarah-Doran.jpg)
... In another experiment, adult male C57BL/6J mice were treated with PLX5622 to remove chronically activated microglia one month after CNS injury and discontinued one week later to allow microglia to regenerate (52). The repopulated microglia showed branching morphology similar to sham-operated mice, while the microglia in-vehicle CNS injury mice showed a typical amoeboid morphology in the chronic posttraumatic state. ...
