Yu Zhang's research while affiliated with Zunyi Medical University and other places
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Publications (2)
It is unclear whether membrane vitamin D receptor (mVDR) exists on the macrophage membrane or whether mVDR is associated with lipopolysaccharide (LPS) tolerance. Herein, we report that interfering with caveolae and caveolae-dependent lipid rafts inhibited the formation of LPS tolerance. VDR was detected as co-localized with membrane molecular marke...
Glucocorticoids are commonly used in clinic, but the immunosuppression seriously hinders their usage. Herein, immunomodulatory effect of artesunate (AS) on hydrocortisone (HC)-induced immunosuppression was investigated. HC-induced immunosuppression mice (HC mice) were established by intramuscular administration with HC (20 mg/kg) once a day for 5 c...
Citations
... In particular, vitamin D supports calcium-phosphorus homeostasis, cell proliferation and differentiation in various organs and systems, bone growth, and mineralization [2,8,9]. In almost all organs and tissues of a human, the vitamin D receptor (VDR) has been detected in the nuclei and on cell membranes [13,14], and cells also contain CYP27B1 (Cytochrome P450 Family 27 Subfamily B Member 1) and CYP24A1 (Cytochrome P450 Family 24 Subfamily A Member 1), as well as coactivator/repressor proteins that regulate the transcription of these proteins. This indicates that cells that include these proteins are able to metabolize and synthesize the active form of 1α,25(OH) 2 D 3 . ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/406694086627332-1473974834627_Q64/Hong-Zhou-21.jpg)
... Glucocorticoids (GCs) have a unique niche in the treatment of inflammatory and autoimmune diseases on account of their obvious immune-suppressive, anti-shock, and anti-inflammatory bioactivities [7]. Hydrocortisone, a kind of glucocorticoid for the treatment of inflammatory diseases, may cause serious adverse effects (immunosuppression, hypertension, and osteoporosis) during long-term and excessive use [8][9][10]. Therefore, in this study, a large dosage of hydrocortisone was used to establish an immunosuppressive model to investigate the effect of natural active peptides on immunosuppression. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273538934374417-1442228172763_Q64/Hong-Zhou-18.jpg)
