Yu-Feng Chu's research while affiliated with Shandong University and other places
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Publications (14)
Purpose:
To evaluate the potential preventive effect of probiotics on ventilator-associated pneumonia (VAP).
Methods:
This was an open-label, randomized, controlled multicenter trial involving 235 critically ill adult patients who were expected to receive mechanical ventilation for ≥48 h. The patients were randomized to receive (1) a probiotics...
To investigate the expression of high mobility group protein B1 (HMGB1) and its receptor, receptor for advanced glycation end-product (RAGE), in renal cancer tissue and surrounding normal tissue and to analyze the relationship between the expression level of the protein and receptor as well as the clinical pathological characteristics and prognosis...
Vascular adventitial fibroblasts (AF) differentiation to myofibroblasts (MF) is the critical physiopathologic feature of vascular remodeling. This study was to investigate the role of RhoA-Rho kinase signaling pathway in AF differentiation to MF induced by transforming growth factor β1 (TGF-β1). The results showed that TGF-β1 up-regulated total Rho...
To investigate the effect of continuous high-volume hemofiltration (CHVHF) in patients with severe acute respiratory distress syndrome (ARDS).
A prospective randomized controlled trial was conducted. Sixty-five patients with severe ARDS admitted to intensive care unit (ICU) from June 2007 to June 2011 were divided into control group (n=28) and trea...
To investigate the role of small G-protein RhoA in neointimal formation following rat carotid artery balloon injury and related mechanisms.
Male 3-4-month-old Sprague-Dawley rats were used in the present study (10 rats per group). Group A: control; Group B: carotid artery balloon injury; Group C: injury + Ad-CMV-eGFP + Pluronic F-127; Group D: inju...
Acute fatty liver of pregnancy (AFLP) is a rare disease of progressive hepatic insufficiency and secondary systemic complications that induce significant maternal risk. The application of combining plasma exchange (PE) and continuous hemodiafiltration (CHDF) is a novel concept for patients with AFLP. Since 2002, we have utilized the combination of...
To evaluate the effects of administration of 6% hydroxyethyl starch (6% HES 130/0.4, voluven) in combination with high volume hemofiltration (HVHF) in patients with ALI and AKI.
One hundred and eight patients with acute lung injury (ALI) and acute kidney injury (AKI) were enrolled from Department of Intensive Care Unit (ICU) of the provincial Hospi...
Background:
High-volume hemofiltration (HVHF) is technically possible in severe acute pancreatitis (SAP) patients complicated with multiple organ dysfunction syndrome (MODS). Continuous HVHF is expected to become a beneficial adjunct therapy for SAP complicated with MODS. In this study, we aimed to explore the effects of fluid resuscitation and HV...
To investigate the regulation mechanism of p38 mitogen-activated protein kinase (p38MAPK) in interleukin-6 (IL-6) expression of vascular smooth muscle cell (VSMC) induced by lipopolysaccharide (LPS).
Rat VSMCs were divided into LPS group, SB203580+LPS group, SB203580 group and control group. LPS group was treated with 100 microg/L LPS for 0, 3, 6,...
Background:
The widespread use of gastrointestinal bleeding prophylaxis in critically ill patients was one of the most controversial issues. Since few studies reported the incidence of gastrointestinal bleeding in mechanically ventilated patients, this study aimed to identify the incidence and risk factors related to gastrointestinal bleeding in p...
To evaluate the effects of high-volume hemofiltration (HVHF) and fluid resuscitation on the levels of arterial lactate and inflammatory cytokines, the acute physiology and chronic health evaluation II (APACHE II) score, and sepsis-related organ failure assessment (SOFA) score in patients with refractory septic shock and multiple organ dysfunction s...
Vascular endothelial growth factor receptors (VEGFRs) are previously considered to exist exclusively in endothelial cells. However, little is known if the receptors are expressed in other non-endothelial cells. In this study, we measured activation of two VEGFRs, Flk-1 and Flt-1, and their biological functions in cultured adventitial fibroblasts an...
Citations
... Animal studies revealed that probiotics may help maintain gut integrity, reducing bacterial translocation and preventing infection in AP (Muftuoglu et al., 2006;van Minnen et al., 2007;Karen et al., 2010). Additionally, some clinical experiments have looked into the possibilities of giving critically ill patients probiotic supplements (Sanaie et al., 2014;Rongrungruang, 2015;Zeng et al., 2016). Based on the promising findings of multiple studies, numerous clinical trials have been conducted to examine the efficacy of using prebiotics, probiotics, and synbiotics in patients with severe AP (SAP) (Karakan et al., 2007;Oláh et al., 2007;Besselink et al., 2008;Cui et al., 2013). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279472927461392-1443642946864_Q64/Chunting-Wang.jpg)
... High-mobility group protein 1 (HMGB1) plays a vital role in inflammation-associated diseases including malignant tumors by promoting the expression of pro-inflammatory cytokines. 20 High HMGB1 levels are frequently identified in various solid tumor types including renal, 21 liver, lung, 22 colorectal 23 and ductal breast cancer, 24 thus suggesting that the aberrant expression of HMGB1 is closely associated with the genesis and progression of the malignant disease. Furthermore, it has been found that blocking extracellular HMGB1 inhibits tumor growth by regulating immune cell infiltration in microenvironment and promotes checkpoint inhibitor-based immunotherapy. ...
... In the current study, 41 patients (11.4 %) had UGIB, and only 15 survived. earlier reports of the incidence of UGIB in ICU by Chu et al. [18] showed a higher incidence of gastrointestinal bleeding if mechanical ventilation exceeded 48 hours (6.7%) with significant life-threatening bleeding had occurred in 3.3%. The length of ICU stay attributable to clinically substantial bleeding should exceed 4-8 days, as documented previously [19] ; in the current study, clinically significant UGIB was observed in 2.4% of patients (6 patients in the deceased subgroup and four patients in the survived subgroup). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/739062814097409-1553217714149_Q64/Mei-Meng-3.jpg)
... After detailed evaluations, 11 RCTs were selected for the final meta-analysis. [22][23][24][25][26][27][28][29][30][31][32] A manual search of the reference lists of these studies did not yield any new eligible studies. The general characteristics of the included studies are presented in Table 1. ...
... To validate the model, 39 input-output experiments in rat or human PAAF cells (reported in 20 papers [61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80]) were classified as observing a significant increase or decrease, or no significant change in activity of an output quantity that is a node in the model in response to a stimulus, that was also an input to the model. The threshold for considering a response in the model to represent a significant change in output activity was chosen to be 0.05. ...
... [25] Plasma exchange combined with continuous renal replacement therapy in patients with severe AFLP and multiorgan dysfunction may improve clinical symptoms and laboratory results. [7] Some studies [7,26] have revealed that early and timely plasma exchange combined with renal replacement therapy or continuous hemodiafiltration within 0-4 days after termination of pregnancy was often effective and safe when hepatic encephalopathy and renal failure occured in patients with AFLP. Owing to the lack of data and relatively rare diseases, it is unclear whether preventive use of plasma exchange is better or delayed plasma exchange until all medical treatments fail. ...
... The flowchart of the articles is depicted in Figure 1. One report was translated from Mandarin [20] and one from German [21] into English to access eligibility. Of 68 potentially eligible studies, three were excluded because they were not RCT, 55 studies did not match the ALI or ARDS criteria, four trials were excluded due to fluids comparison [20,[22][23][24], and three studies did not report the outcome investigated by this review [25][26][27]. ...
... The previous studies in China (16)(17)(18)(19)(20) indicated that the ratio of ICU to hospital beds ranged from 1.4% to 2.2%, which was similar to our result (1.76%). However, we are not able to conduct the comparison of results such as ICU beds and staff with the previous studies because they only provided the total numbers without the per capita values. ...
... При использовании данного метода происходит перенос токсинов, растворенных в фильтрующейся по градиенту гидростатического давления жидкости через полупроницаемую мембрану. В ОРИТ предпочтение отдается продолжительной методике ГДФ (CVVHDF -Continuous Veno-Venous Hemodiafiltration, продолжительная вено-венозная ГДФ) [17,18]. Замещение удаленной жидкости происходит в режиме пре-или постдилюции, т.е. ...
... Because of these effects, VEGF actively regulates the angiogenesis of normal and pathological blood vessels [78][79][80]. VEGF and VEGF receptors (VEGFRs) are expressed on both endothelial and nonendothelial cells [81,82]. Currently, the use of anti-VEGF and anti-VEGF receptor therapies to block angiogenesis in cancer or other pathological processes is considered extremely important. ...
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