January 2015
·
33 Reads
·
1 Citation
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
January 2015
·
33 Reads
·
1 Citation
January 2011
·
112 Reads
·
27 Citations
Journal of Investigational Allergology and Clinical Immunology
Interleukin (IL) 13, a type 2 helper T cell (T(H)2), is an important regulator of inflammatory immune responses. It mediates its action through a receptor complex consisting of IL-13Ralpha1 and IL-4Ralpha. IL-13Ralpha2 binds IL-13 with high affinity and is thought to act primarily as a decoy receptor, sequestering IL-13 and thus inhibiting its action. Our aim was to clarify the role of these receptors in the diagnosis and follow-up of atopic patients. We genotyped the 1398A>G polymorphism in the IL-13Ralpha1 gene using restriction fragment length polymorphism for causal genetic diversity and measured serum levels of IL-13Ralpha2 in 105 atopic patients suffering from atopic asthma, atopic dermatitis, and atopic rhinitis (35 each). We compared the results with those of 35 nonatopic control individuals. Total immunoglobulin (Ig) E and serum IL-13Ralpha2 were measured using enzyme-linked immunosorbent assay, and the eosinophil counts were recorded. A significant increase in serum IL-13Ralpha2 levels was recorded in the 3 atopic groups compared with the control group (P < .001), as well as a significant increase in total IgE levels and eosinophil counts. No significant association was found between 1398A>G and atopy other than a suggestive association between this polymorphism and raised total serum IgE levels in all 3 atopic groups (P < .001). These findings indicate that IL-13Ralpha2 plays an important role in atopy and that increased levels in different groups highlight its regulatory role in the development of atopic symptoms. The 1398A>G polymorphism might be involved in the production of IgE.
June 2010
·
34 Reads
Bulletin of Egyptian Society for Physiological Sciences
January 2010
·
13 Reads
ABSTRACT The dissemination of hepatocellular carcinoma (HCC) cells into the circulation plays a critical role in postoperative recurrence and metastasis. Early detection of metastatic tumor cells is critical to identify HCC patients at high risk of relapse. MAGE-3 and -4 genes were evaluated by reverse transcription polymerase chain reaction for the possibility of using them as new markers for early detection of metastases in 160 HCV Egyptian patients, 115 of them were complicated with HCC. The expression of MAGE-3 and MAGE-4 mRNA in peripheral blood of patients with metastatic HCC, were 36 % and 52%, respectively. While the expression of MAGE-3 and MAGE-4 mRNA in peripheral blood of patients with localized HCC, were 12 % and 16%, respectively. Moreover at least one type of MAGE-3 or MAGE-4 mRNA was found in the peripheral blood of 68% of the metastatic HCC patients and in 20% of the localized HCC patients. While neither the controls nor the cirrhotic patients show expression of MAGE-4 mRNA in their peripheral blood. MAGE-3 and MAGE-4 may be a promising diagnostic tool for monitoring the prognosis of HCC patients and early detection of occult hematogenous metastasis of HCC.
January 2004
·
27 Reads
... The binding of either IL-4 or IL-13 to IL-13Rα1 recruits IL-4Rα, causing dimerization of the receptors, activation of Janus kinase 1 (JAK1) and tyrosine kinase 2 (TYK2), and phosphorylation of a signal transducer and activator of transcription 6 (STAT6), which promotes Th2 differentiation [8,20,52]. IL-13 also has a high affinity for the IL-13Rα2 receptor, which plays a role in the endogenous regulation of IL-13 and in the itch-scratch cycle, collagen deposition, and fibrotic tissue remodeling [34,53,54]. Thus, IL-13 may contribute to histamine-independent stimulation of afferent nerve endings and pruritus [34]. ...
January 2011
Journal of Investigational Allergology and Clinical Immunology
... 196M/R SNP consists of a single base substitution at codon 196 (ATG3AGG), which results in a neoconservative amino acid substitution (methionine [M]?arginine [R]) within the fourth extracellular domain of TNFRII 29 .The analysis of the SNP at position + 196 (rs 1061622) in exon 6 of the TNFRII gene was undertaken since this polymorphism occurs in the extracellular domain of the receptor and may affect in vivo receptor functioning. Indeed, it has been shown to be important for TNF-α binding [30][31][32] . ...
January 2015