December 2023
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2 Reads
Natural Product Sciences
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December 2023
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2 Reads
Natural Product Sciences
February 2023
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56 Reads
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9 Citations
Biomaterials
Poly-(methyl methacrylate) (PMMA) is the preferred biomaterial for orofacial prostheses used for the rehabilitation of naso-palatal defects. However, conventional PMMA has limitations determined by the complexity of the local microbiota and the friability of oral mucosa adjacent to these defects. Our purpose was to develop a new type of PMMA, i-PMMA, with good biocompatibility and better biological effects such as higher resistance to microbial adhesion of multiple species and enhanced antioxidant effect. The addition of cerium oxide nanoparticles to PMMA using a mesoporous nano-silica carrier and polybetaine conditioning, resulted in an increased release of cerium ions and enzyme mimetic activity, without tangible loss of mechanical properties. Ex vivo experiments confirmed these observations. In stressed human gingival fibroblasts, i-PMMA reduced the levels of reactive oxygen species and increased the expression of homeostasis-related proteins (PPARg, ATG5, LCI/III). Furthermore, i-PMMA increased the levels of expression of superoxide dismutase and mitogen-activated protein kinases (ERK and Akt), and cellular migration. Lastly, we demonstrated the biosafety of i-PMMA using two in vivo models: skin sensitization assay and oral mucosa irritation test, respectively. Therefore, i-PMMA offers a cytoprotective interface that prevents microbial adhesion and attenuates oxidative stress, thus supporting physiological recovery of the oral mucosa.
April 2021
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4 Reads
Fashion & Textile Research Journal
December 2020
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37 Reads
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16 Citations
BMC Pharmacology and Toxicology
Background Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (< 65 years). Methods Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. We estimated the number of ADRs per 1000 patients exposed to the major culprit drugs, and incidence rate ratios were obtained to assess high- and low-risk medications in older adults. Results In total, 4152 (22.0%) ADRs were reported for 3437 older adults (mean age, 74.6 years and 57.3% female). Tramadol (rate ratio, 1.32; 95% confidence interval [CI], 1.21–1.44; P < 0.001) and fentanyl (1.49, 1.16–1.92, P = 0.002) posed higher risks of ADRs in the older adults, whereas nonsteroidal anti-inflammatory drugs (NSAIDs) (0.35, 0.30–0.40, P < 0.001) and iodinated contrast media (ICM) (0.82, 0.76–0.89, P < 0.001) posed lower risks. Ratios of serious ADRs to NSAIDs (odds ratio, 2.16; 95% CI, 1.48–3.15; P < 0.001) and ICM (2.09, 1.36–3.21, P = 0.001) were higher in the older adults than in the younger patients. Analgesics primarily elicited cutaneous ADRs in the younger patients and gastrointestinal reactions in the older adults. ICM more commonly led to anaphylaxis in the older adults than the younger patients (3.0% vs. 1.6%, P = 0.019). Conclusion For early detection of ADRs in older adults, better understanding of differences in the causes and characteristics thereof in comparison to the general population is needed.
October 2020
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20 Reads
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2 Citations
Journal of Periodontal & Implant Science
Purpose: The objective of this study was to investigate whether phelligridin D could reduce glucose-induced oxidative stress, attenuate the resulting inflammatory response, and restore the function of human periodontal ligament cells (HPDLCs). Methods: Primary HPDLCs were isolated from healthy human teeth and cultured. To investigate the effect of phelligridin D on glucose-induced oxidative stress, HPDLCs were treated with phelligridin D, various concentrations of glucose, and glucose oxidase. Glucose-induced oxidative stress, inflammatory molecules, osteoblast differentiation, and mineralization of the HPDLCs were measured by hydrogen peroxide (H₂O₂) generation, cellular viability, alkaline phosphatase (ALP) activity, alizarin red staining, and western blot analyses. Results: Glucose-induced oxidative stress led to increased production of H₂O₂, with negative impacts on cellular viability, ALP activity, and calcium deposition in HPDLCs. Furthermore, HPDLCs under glucose-induced oxidative stress showed induction of inflammatory molecules (intercellular adhesion molecule-1, vascular cell adhesion protein-1, tumor necrosis factor-alpha, interleukin-1-beta) and disturbances of osteogenic differentiation (bone morphogenetic protein-2, and -7, runt-related transcription factor-2), cementogenesis (cementum protein-1), and autophagy-related molecules (autophagy related 5, light chain 3 I/II, beclin-1). Phelligridin D restored all these molecules and maintained the function of HPDLCs even under glucose-induced oxidative stress. Conclusions: This study suggests that phelligridin D reduces the inflammation that results from glucose-induced oxidative stress and restores the function of HPDLCs (e.g., osteoblast differentiation) by upregulating autophagy.
August 2020
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43 Reads
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14 Citations
Journal of Applied Polymer Science
In this study, a series of thermoresponsive cross‐linked copolymer poly [N‐isopropylacrylamide(NIPAm)‐co‐N‐isopropylmethacrylamide(NIPMAm)] (P‐M series samples: P‐M‐0, 10, 20, 30, 40, where numbers are co‐monomer contents) hydrogels were prepared by free radical polymerization using the main monomer N‐isopropylacrylamide (NIPAm), co‐monomer N‐isopropylmethacrylamide (NIPMAm), cross‐linking agent N, N‐methylenebisacrylamide, initiator (ammonium persulfate)/catalyst, and solvent water. In addition, a series of samples [P‐G series samples: P‐G‐0, 10, 20, 30, 40, where numbers are co‐solvent glycerol content) were prepared using P‐M‐40 as components and water/co‐solvent glycerol as a mixed solvent. The effects of co‐monomer NIPMAm and co‐solvent glycerol contents on the lower critical solution temperature (LCST)/freezing temperature and light transmittance as function of temperature of the prepared copolymer gels were investigated. The resulting thermoresponsive polymer gels had LCSTs in the range of 17.9 to 38.7°C and freezing points in the range of 6.3 to −38.5°C. These gels are suitable materials for smart windows that are responsive to various environmental conditions.
August 2020
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57 Reads
Background Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥ 65 years) in comparison to younger individuals (< 65 years). Methods Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. Subjects exposed to major culprits were extracted from cohorts transformed to the Observational Medical Outcomes Partnership Common Data Model during the study period. Results In total, 4,152 (22.0%) ADRs were reported for 3,437 older adults (mean age, 74.6 years and 57.3% female). Tramadol (rate ratio, 1.32; 95% confidence interval [CI], 1.21–1.44; P < 0.001) and fentanyl (1.49, 1.16–1.92, P = 0.002) posed higher risks of ADRs in the older adults, whereas nonsteroidal anti-inflammatory drugs (NSAIDs) (0.35, 0.30–0.40, P < 0.001) and iodinated contrast media (ICM) (0.82, 0.76–0.89, P < 0.001) posed lower risks. Ratios of serious ADRs to NSAIDs (odds ratio, 2.16; 95% CI, 1.48–3.15; P < 0.001) and ICM (2.09, 1.36–3.21, P = 0.001) were higher in the older adults than in the younger patients. Analgesics primarily elicited cutaneous ADRs in the younger patients and gastrointestinal reactions in the older adults. ICM more commonly led to anaphylaxis in the older adults than the younger patients (3.0% vs. 1.6%, P = 0.019). Conclusion For early detection of ADRs in older adults, better understanding of differences in the causes and characteristics thereof in comparison to the general population is needed.
August 2020
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12 Reads
Background: Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (<65 years). Methods: Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. We estimated the number of ADRs per 1,000 patients exposed to the major culprit drugs, and incidence rate ratios were obtained to assess high- and low-risk medications in older adults. Results: In total, 4,152 (22.0%) ADRs were reported for 3,437 older adults (mean age, 74.6 years and 57.3% female). Tramadol (rate ratio, 1.32; 95% confidence interval [CI], 1.21-1.44; P<0.001) and fentanyl (1.49, 1.16-1.92, P=0.002) posed higher risks of ADRs in the older adults, whereas nonsteroidal anti-inflammatory drugs (NSAIDs) (0.35, 0.30-0.40, P<0.001) and iodinated contrast media (ICM) (0.82, 0.76-0.89, P<0.001) posed lower risks. Ratios of serious ADRs to NSAIDs (odds ratio, 2.16; 95% CI, 1.48-3.15; P<0.001) and ICM (2.09, 1.36-3.21, P=0.001) were higher in the older adults than in the younger patients. Analgesics primarily elicited cutaneous ADRs in the younger patients and gastrointestinal reactions in the older adults. ICM more commonly led to anaphylaxis in the older adults than the younger patients (3.0% vs. 1.6%, P=0.019). Conclusion: For early detection of ADRs in older adults, better understanding of differences in the causes and characteristics thereof in comparison to the general population is needed.
August 2020
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26 Reads
Background: Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (<65 years). Methods: Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. We estimated the number of ADRs per 1,000 patients exposed to the major culprit drugs, and incidence rate ratios were obtained to assess high- and low-risk medications in older adults. Results: In total, 4,152 (22.0%) ADRs were reported for 3,437 older adults (mean age, 74.6 years and 57.3% female). Tramadol (rate ratio, 1.32; 95% confidence interval [CI], 1.21-1.44; P <0.001) and fentanyl (1.49, 1.16-1.92, P =0.002) posed higher risks of ADRs in the older adults, whereas nonsteroidal anti-inflammatory drugs (NSAIDs) (0.35, 0.30-0.40, P <0.001) and iodinated contrast media (ICM) (0.82, 0.76-0.89, P <0.001) posed lower risks. Ratios of serious ADRs to NSAIDs (odds ratio, 2.16; 95% CI, 1.48-3.15; P <0.001) and ICM (2.09, 1.36-3.21, P= 0.001) were higher in the older adults than in the younger patients. Analgesics primarily elicited cutaneous ADRs in the younger patients and gastrointestinal reactions in the older adults. ICM more commonly led to anaphylaxis in the older adults than the younger patients (3.0% vs. 1.6%, P =0.019). Conclusion: For early detection of ADRs in older adults, better understanding of differences in the causes and characteristics thereof in comparison to the general population is needed.
January 2020
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666 Reads
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6 Citations
To prepare flame-retardant epoxy resin, phosphorus compound containing di-hydroxyl group (10-(2,5-dihydroxyphenyl)-9,10-dihydro-9-oxa-10-phospha phenanthrene-10-oxide, DOPO-HQ) was reacted with uncured epoxy resin (diglycidyl ether of bisphenol A, YD-128) and then cured using a curing agent (dicyandiamide, DICY). This study focused on the effect of phosphorus compound/phosphorus content on physical properties and flame retardancy of cured epoxy resin. The thermal decomposition temperature of the cured epoxy resins (samples: P0, P1.5, P2.0, and P2.5, the number represents the wt% of phosphorus) increased with increasing the content of phosphorus compound/phosphorus (0/0, 19.8/1.5, 27.8/2.0, and 36.8/2.5 wt%) based on epoxy resin. The impact strength of the cured epoxy resin increased significantly with increasing phosphorus compound content. As the phosphorus compound/phosphorus content increased from 0/0 to 36.8/2.5 wt%, the glass transition temperature (the peak temperature of loss modulus curve) increased from 135.2°C to 142.0°C. In addition, as the content of phosphorous compound increased, the storage modulus remained almost constant up to higher temperature. The limiting oxygen index value of cured epoxy resin increased from 21.1% to 30.0% with increasing phosphorus compound/phosphorus content from 0/0 to 36.8/2.5 wt%. The UL 94 V test result showed that no rating for phosphorus compounds less than 19.8 wt% and V-1 for 27.8 wt%. However, when the phosphorus compound was 36.8 wt%, the V-0 level indicating complete flame retardancy was obtained. In conclusion, the incorporation of phosphorus compounds into the epoxy chain resulted in improved properties such as impact strength and heat resistance, as well as a significant increase in flame retardancy.
... In particular, cerium oxide nanoparticles (CeO 2 ) are known for their superoxide dismutase (SOD)-mimicking properties 11 . The term "nanoezyme" refers to a nano-inorganic compound mimicking enzymes 12 . The H 2 O 2 produced in this process can speci cally target bacteria and exhibit antibacterial activity 13 . ...
February 2023
Biomaterials
... There is evidence showing that elderly consume more drugs than younger people and number of drugs prescribed increases with age 14 . There is also an increase in the incidence of adverse reactions with a greater number of drugs' prescriptions 15 . In our study women consumed more drugs than men which is similar to the report by other authors. ...
December 2020
BMC Pharmacology and Toxicology
... For example, using the glycerol additive, Jang et al. reported thermally responsive PNIPA-based polymer gels with LCST in the range of 17.9−38.7°C. 15 Glycerol has also been used to change the transition temperature of the HPC solution-based smart window. 35 Phase transition temperature in the range of 21−30°C has been reported for HPC-AAm hydrogels using CaCl 2 as an additive. ...
August 2020
Journal of Applied Polymer Science
... In fact, little is known about the cementoblastic differentiation of BM-MSCs [54] compared to PDLSCs or dental stem cells in general. Nevertheless, CEMP-1 was downregulated at the protein level in PDL cells cultured under HG conditions in a time-dependent manner [55]. Reduced cementum thickness was noted in extracted teeth of D vs. ND subjects [56]. ...
October 2020
Journal of Periodontal & Implant Science
... The presence of phosphorus atoms in the structure of the cured epoxy resins, even in low concentration, can improve their flame resistance [9][10][11]. Phosphorus compounds are environmentally friendly and exhibit low toxicity. ...
January 2020
... Any of these 4 drugs or the insect sting itself could have acted as allergens, causing the anaphylactic shock and/or Kounis syndrome. 4,5,6,7 Paradoxically adrenaline, the drug that is life-saving in anaphylaxis, can by itself induce anaphylaxis. Indeed, every commercially available preparation of adrenaline contains sodium metabisulfite as a preservative, according to Drug Facts and Comparisons (a standard pharmacy reference published by Wolters Kluwer and updated monthly). ...
December 2019
Medicine
... Among thermotropic materials, one of the most widely studied is poly(N-isopropy lacrylamide), which forms thick hydrogels with LCST around 30-32 • C in its homopolymer form [12][13][14], and whose properties can be adapted and modified by mixing it with colloidal particles [15], with nanomaterials [16], or by copolymerization with different monomers [17,18]. Other examples of thermoregulated reversible sol/gel transition have been reported for different copolymers, e.g., ulvan-grafted poly(Nvinylcaprolactam) [19], poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) (PEOPPO-PEO) [20], and poly(ethylene glycol-b-L-lactic acid-b-ethylene glycol) (PEG-PLLA-PEG) [21]. ...
November 2019
... POSS is an inorganic and organic component with a rigid structure [19,20] which is associated with the chemical and physical bonds to form the synergistic effect to efficiently perform the thermal, mechanical and surface properties. Thus, it becomes the most potential representative in the process of the material structure design [21][22][23][24][25]. Ajaya K. Nanda et al. [26] studied the effect of diamino-POSS on the properties of polyurethane materials. ...
July 2019
Molecular Crystals and Liquid Crystals
... For the same reason, values below this cut-off have been shown to be relevant (25). This arbitrary cut-off has been under debate in different publications that, using different approaches, have tried to find cut-offs for sIgE aligned with clinical reality, both for diagnosis (26)(27)(28) and treatment (indication of AIT or provocation tests, both of them with side effects) (4,(29)(30)(31). Few studies have been published specifically looking for these cut-offs in the diagnosis of seasonal rhinitis and or asthma to date (32,33). ...
October 2018
Yonsei Medical Journal
... In brief, the customer demand for PU synthetic leather is increased. As a consequence, solvent-borne of wet process products [20] are dominant in the markets due to their soft handle feeling [21], breathability, and abrasion resistance in the PU synthetic leather industry; however, it contains 70% Dimethylformamide (DMF), which accounts for roughly 2500 tons/year by the wet-type synthetic leather. The other solvent that methyl ethyl ketone (MEK) and toluene are used as the carrier of DMF. ...
September 2018