Yoojung Kim's research while affiliated with Chonnam National University and other places
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Publications (6)
Rationale:
Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor that lacks a conventional DNA-binding domain. Through interactions with other transcription factors, SHP regulates diverse biological events, including glucose metabolism in liver. However, the role of SHP in adult heart diseases has not yet been demonstrated....
Background: Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor lacking DNA binding domain. SHP directly modulates the activities of other nuclear receptors and regulates a variety of cellular events such as cell differentiation, proliferation, and metabolism in various tissues. However, the role of SHP in heart has not ye...
Background. Cardiac hypertrophy is characterized by transcriptional reprogramming of fetal gene expression, and histone modifiers are tightly linked to the regulation of those genes. We previously reported that activation of histone deacetylase (HDAC) 2, one of the class I HDACs, mediates hypertrophy. Here we suggest that disinhibiting of kruppel-l...
Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor that regulates a variety of cellular events such as cell proliferation, differentiation and metabolism in liver and bone. However, the role of SHP in heart has not yet been elucidated. In this study, we investigated the functional roles of SHP in cardiac hypertrophy. In r...
Cardiac hypertrophy is characterized by transcriptional reprogramming of fetal gene expression, and histone deacetylases (HDACs) are tightly linked to the regulation of those genes. We previously demonstrated that activation of HDAC2, 1 of the class I HDACs, mediates hypertrophy. Here, we show that casein kinase-2α1 (CK2α1)-dependent phosphorylatio...
Citations
... In vivo study showed that SHP-null mice showed a cardiac hypertrophy. In addition, the metformin-induced antihypertrophic effect was diminished in SHP-null mice or by SHP small interfering RNA in cardiomyocytes [254]. SHP gene is regulated by several NRs, including FXR, liver receptor homolog-1, ERRγ, ERα, LXR, and SF-1 [252,255,256]. ...
... CK2 is composed of two catalytic subunits (α and/or αʹ) and regulatory subunits (β). Several studies suggest that the α catalytic subunit has important kinase activity and is the primary functional subunit for disease treatment [14,58,59]. The β subunit is likely responsible for the oncogenic potential of CK2. ...
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