Yongyang Liu's research while affiliated with Chinese Academy of Sciences and other places
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Publications (12)
Almost all physiological processes of animals are controlled by the brain, including language, cognitive, memory, learning, emotion and so forth. Minor brain dysfunction usually leads to brain diseases and disorders. Therefore, it' is greatly meaningful and urgent for scientists to have a better understanding of brain structure and function. Optica...
Early monitoring of gastrointestinal diseases via orally delivered NIR-II ratiometric fluorescent probes represents a promising noninvasive diagnostic modality, but is challenging due to the limitation of harsh digestive environment. Here, we report a single-component NIR-II ratiometric molecular nanoprobe (LC-1250 NP) to monitor gastrointestinal d...
Axonal transport plays a significant role in the establishment of neuronal polarity, axon growth, and synapse formation during neuronal development. The axon of a naturally growing neuron is a highly complex and multifurcated structure with a large number of bends and branches. Nowadays, the study of dynamic axonal transport in morphologically comp...
Cd-based quantum dots (QDs) have broad applications in biomedicine, electronics, and energy. Thus, their environmental and health risks have garnered attention owing to the toxicity of Cd. However, there is limited knowledge on the long-term chemical biotransformation and pathway of Cd-based QDs in mammals. Herein, the biodistribution and excretion...
Controllable regulation of stem cell differentiation is a critical concern in stem cell-based regenerative medicine. In particular, there are still great challenges in controlling the directional differentiation of neural stem cells (NSCs) into neurons. Herein, we developed a novel linear-branched poly(β-amino esters) (S4-TMPTA-BDA-DT, STBD) throug...
Axonal transport plays a significant role in the establishment of neuronal polarity, axon growth, and synapse formation during neuronal development. The axon of a naturally growing neuron is a highly complex and multifurcated structure with a large number of bends and branches. Nowadays, the study of dynamic axonal transport in morphologically comp...
Alzheimer's disease (AD) is a common dementia that is currently incurable. The existing treatments can only moderately relieve the symptoms of AD to slow down its progress. How to achieve effective neural regeneration to ameliorate cognitive impairments is a major challenge for current AD treatment. Here, the therapeutic potential of a nanoformulat...
The neural membrane potential of nerve cells is the basis of neural activity production, which controls advanced brain activities such as memory, emotion, and learning. In the past decades, optical voltage indicator has emerged as a promising tool to decode neural activities with high‐fidelity and excellent spatiotemporal resolution. In particular,...
Light‐based technique, including optical imaging and photoregulation, has become one of the most important tools for both fundamental research and clinical practice, such as cell signal sensing, cancer diagnosis, tissue engineering, drug delivery, visual regulation, neuromodulation, and disease treatment. In particular, low energy near‐infrared (NI...
Citations
... Optical fluorescence imaging has been utilized for monitoring biological activities, offering unprecedented insights into cellular processes as well as the diagnosis and treatment of human diseases [1][2][3]. Near-infrared (NIR) fluorescence, spanning the range of 650-1700 nm, presents a distinct advantage over visible fluorescence detection [4,5]. Its larger dynamic range and diminished background fluorescence, attributed to reduced tissue absorption, scattering, and autofluorescence, make it an invaluable tool for sophisticated imaging techniques [6,7]. ...
... In addition, Chen et al. [19] developed a hollow nano US contrast agent with satisfactory ability to image atherosclerotic plaques. Regarding nano-contrast agents for inflammatory diseases, Li et al. [20] designed the second near infrared window nano-fluorescent probe to detect gastrointestinal diseases by responding to inflammation-related markers. ...
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... There is a growing interest in ss-DNA [54] and also RNA analysis [55] using nanopores. Several studies have been performed using both biological and synthetic nanopores. ...
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... TrackMate is an ImageJ plugin developed by Tinevez et al. for particle tracking based on the particle pixel size [42]. Although it was built for particle tracking, in application, it has also been used for tracking blood cells [43,44], lysosomes [45,46], and even Drosophila movement [47,48]. ...
... The technological aspect of these QDs has been well explored and highly investigated. However, the consequences and implications of their unexpected interactions and physiological responses in living organisms as potential ecotoxicants raise a concern about the environment's and biological species' health, growth rate, physical activities, and energy-harvesting properties (Nagy et al. 2012;Nikazar et al. 2020;Gupta et al. 2021;Chen et al. 2022;Ünlü et al. 2022). The limited knowledge about the interaction of biological molecules like DNA, membrane lipids, proteins, enzymes, etc., as they play important roles in biochemical reactions, metabolism, replications, and so on, with nanostructures raises serious concerns about their applications Parra et al. 2016;Gupta et al. 2021;Huang et al. 2020;Cao et al. 2021). ...
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... In this special issue, Cao et al developed a novel linear-branched poly (β-amino esters) (called STBD) nanocarrier with multiple positively charged amine terminus and degradable intermolecular ester bonds for efficient gene loading and delivery, and effective gene release and transcription in neural stem cells (NSCs). Thereby, the levels of neuronal differentiation and maturation of NSCs were significantly enhanced after delivering siRNA (shSOX9) expression plasmid into NSCs for silencing the SOX9 gene in NSCs by the STBD nanocarrier [9]. The STBD/deoxyribonucleic acid nano-polyplex may serve as a powerful nonviral approach for gene delivery in NSCs, showing broad application prospects in NSC-based regenerative medicine. ...
... There is a long history of interest in neural regeneration (Stahnisch, 2021) and now renewed interest in regenerative interventions for neurodegenerative disorders and nervous system injury (Huang et al., 2021). When applied to mental health, the principle postulates implicit processes that have an intrinsic directionality or 'teleology' to them -that is, they move towards an end goal which, in the present context, may be (non-exclusively) healing, recovery or 'wholeness' (Grof, 2012;Vaid & Walker, 2022). ...
... Since membrane potential is closely related to neural activity in the brain, several voltage-sensitive organic molecules were used for imaging cell membrane potential [382]. Loew et al. [383] introduced a palette of fluorinated styryl dyes that show improved photostability. ...
Reference: Structural and functional imaging of brains
... This makes ICG particularly suitable for imaging biological tissues, which have lower absorption in this spectral range and allow deeper light penetration. ICG has an amphiphilic molecular structure, exhibiting hydrophilicity and lipophilicity [34,35], which enhances its application versatility in various environments [36][37][38]. Therefore, the use of ICG in research can significantly sharpen the imaging resolution and contrast, enabling precise visualization of the adjuvants' transport process. ...
