Yongsheng Che's research while affiliated with State Key Laboratory of Medical Genetics of China and other places

... Several Agrobacterium strains such as AGL1, GV3101, EHA105, EHA101, and LBA4404 have been used in cucumber transformation [15], but there is no report that compared the transformation efficiency of different strains. We compared the transformation efficiency between AGL1 and GV3101. ...

Reference:

Improving Agrobacterium tumefaciens−Mediated Genetic Transformation for Gene Function Studies and Mutagenesis in Cucumber (Cucumis sativus L.)

... They are known as broad spectrum toxins with botrydiol derivatives causing leasions to the leaves [4]. Other bioactivities include fungicide ISSN 1394 -2506 and cytotoxic activities [5]. Even though sesquiterpenes form the largest group of terpenes and include commercially important compounds, they are difficult to chemically synthesize because of the complex structure that often leads to low yield [6]. ...

Reference:

Isolation of two botryanes from Hypoxylon rickii and identification of the encoding genes

... Finally, the absolute configuration of (7S)-4 was elucidated via ECD calculations (Figure 4). In addition to these four new isolates, five previously reported isolates were acquired, which were identified on the basis of comparing their spectral data with the reported data as pestalotiopyrone I (5) [10], ficipyrone A (6) [11], 4-(hydroxymethyl)-5,7-dimethoxy-6methylisobenzofuran-1(3H)-one (7) [12], mycophenolic acid (8) [13], and terezine A (9) [14]. ...

Reference:

New Meroterpenoids and α-Pyrone Derivatives Isolated from the Mangrove Endophytic Fungal Strain Aspergillus sp. GXNU-Y85

... Anti-HIV bioactive compounds from fungi are widely considered to be one of the most promising sources. Several compounds, including alachalasin A from Podospora vesticola fungus cultures, have been identified as effective HIV-1 replication suppressors in cellosaurus cells C8166 [25,26]. The half-maximal effective concentration, or EC 50 , of alachalasin is 8.01 µM. ...

Reference:

Microbial Natural Products with Antiviral Activities, Including Anti-SARS-CoV-2: A Review

... No. 27 [2,3]; the expansolides, tetracyclic sesquiterpene lactones from Penicillumexpansum and Aspergillus fumigatus Fresenius [4], and the massarinolins, antibacterial agents from the aquatic fungus Massarina tunicate [5]. Endophytic fungi, which inhabit normal tissues of hosts without causing apparent symptoms of pathogenesis, are rich sources of bioactive natural products6789101112. In an ongoing search for new bioactive secondary metabolites, a strain of Paraconiothyrium brasiliense Verkley (M3-3341) isolated from the branches of Acer truncatum Bunge on Dongling Mountain, Beijing, China, was investigated, leading to the discovery of brasilamides A–D, four new bergamotane sesquiterpenes with anti-HIV-1 activity [13]. ...

Reference:

New Bergamotane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense

... Some products from the genus might be important as drug lead compounds for the treatment of human diseases and control of plant diseases e.g. cytotoxic torreyanic acid [7], cytotoxic chloropestolide A [8], and antifungal isopestacin [9]. In order to search for new structural and active compounds, a strain, Pestalotiopsis sp. ...

Reference:

Pestalpolyols A–D, Cytotoxic Polyketides from Pestalotiopsis sp. cr013

... Species of Diaporthe are also prevalent as endophytes associated with many hosts in temperate and tropical regions (Rossman, Farr, & Castlebury, 2007; Udayanga et al., 2011). Endophytes are microorganisms inhabiting the living plant organs without causing apparent harm to the host (Petrini, 1991), and have been proven to be a promising source of natural active substances (Ding, Liu, Guo, Zhou, & Che, 2008; Li, Jiang, Guo, Zhang, & Che, 2008; Fang, Yang, Zhu, Zeng, & Li, 2013). Fang et al. (2013reported that the colonization rate of endophytic fungi in C. sinensis was high (81.00‒98.86%). ...

Reference:

Unravelling Diaporthe species associated with Camellia

... Pestalachloride A, a new chlorinated benzophenone alkaloid produced by Pestalotiopsis adusta, showed potent antifungal activity against Fusarium culmorum with an IC 50 value of 0.89 µM [10]. The first chlorinated pupukeanane derivative, chloropupukeananin, which was isolated from fermentation broth of Pestalotiopsis fici, isolated from fermentation broth of Pestalotiopsis fici, inhibited HIV-1 replication in C8166 cells with an IC50 value of 14.6 μM [11]. Pestaloquinols A and B, two unique isoprenylated epoxyquinol derivatives obtained from rice cultures of Pestalotiopsis sp., both exhibited cytotoxicity against HeLa cell line with IC50 values of 8.8 μM [12]. ...

Reference:

Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae

... Bergamotane-sesquiterpenoids are among the commonly reported sesquiterpenes from this fungus [13]. In 2010, Liu et al. isolated and purified new bergamotanesesquiterpenes: brasilamides A-D (1-4) and the known pinthunamide (14) from the Acer truncatum-associated strain M3-3341 obtained from Dongling Mountain/Beijing/ China that were characterized by nuclear magnetic resonance (NMR), circular dichroism (CD), and Xray analyses (Fig. 2) [25]. Compounds 1 and 2 feature unique skeletons, including 4-oxatricyclo[3.3.1.0 ...

Reference:

Shedding light on Paraconiothyrium brasiliense: Secondary metabolites, biological activities, and computational studies

... Interestingly, co-culture of P. microspora with Streptomyces lividans caused an approximately 10-fold enhanced accumulation of pestalotioprolide E (80) and pestalotioprolide F (81), compared to axenic fungal controls [118]. The enhanced accumulation is beneficial for the formation of pestalotioprolide E (80) and pestalotioprolide F (81), and attention should be directed to associated molecular pathways. ...

Reference:

Pestalotiopsis Diversity: Species, Dispositions, Secondary Metabolites, and Bioactivities