Yongjing Cheng's research while affiliated with Beijing Hospital and other places

... Escherichia coli in pSS patients was found to have an amino acid sequence similar to that of pSS-relevant autoepitopes. This suggests that Escherichia coli contributes to the pathogenesis of pSS [65]. Recently, thanks to the results of studies in mice, it has been suggested that Lactobacillus acidophilus and propionate have therapeutic potential for the treatment of SS. ...

... Immune thrombocytopenia due to autoimmune platelet destruction may present as a chronic complication or acutely during a disease flare. Other causes of thrombocytopenia include medications, splenomegaly, a thrombotic microangiopathy, or antiphospholipid syndrome [7]. ...

... It is suspected that blocking these actions causes paradoxical ophthalmic adverse effects. [13] Peripheral ulcerative keratitis occurred during a diagnosis of the disease in a patient with RA described by Huang et al., [14] and both RA and PUK went into remission after starting tocilizumab treatment. ...

... The second route followed for the discovery of specific signatures of RA is based on a strong presence of antibodies against citrullinated proteins that appear long before the development of the pathology. On these bases, a study has been established to determine the presence of citrullinated autoantigens among the pool of overexpressed proteins [52]. Serum samples from patients were subjected to treatment with CPLL and protein abnormalities were determined by mass spectrometry. ...

... There have been reports indicating that salivary gland USG scores are correlated with both clinical and serological findings in Sjogren's syndrome. In studies comparing the homogeneity of salivary glands in individuals with Sjogren's syndrome and a healthy control group using USG, the scores of patients with Sjogren's syndrome were significantly higher than those of the control group [16][17][18][19]. Lee et al. [20] reported that the salivary gland parenchyma of patients with systemic sclerosis exhibits greater heterogeneity than in individuals with idiopathic sicca syndrome and less heterogeneity than in individuals with primary Sjögren's syndrome. Badarinza et al. [21] evaluated the parotid and submandibular salivary glands of obese and diabetic patients and healthy individuals using USG. ...

... [37] In a recent report, Liu et al. reviewed the clinical records, laboratory results, and chest computed tomography scans of five geriatric severe COVID-19 patients who were treated with tocilizumab. [38] Most of the patients (4/5) showed clinical improvements and were discharged from the hospital after treatment, suggesting that tocilizumab may serve as an effectivetherapyforsevereCOVID-19patients.Astheelderly are susceptible to SARS-CoV-2 infection and vulnerable to glucocorticoid-relatedsideeffects,thisstudymayhelpphysicians to better understand the efficacy and outcomes of tocilizumab applications in severe geriatric COVID-19 patients. ...

... Recent reports suggest that circulating miRNAs have great potential as diagnostic and prognostic biomarkers in connective tissue diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and ankylosing diseases [9][10][11][12]. We previously reported that plasma miR-320c may be involved in the development of OA, as indicated by miRNA chip screening [13]. To date, few studies have addressed the mechanism of miR-320 in OA development [14][15][16]. ...

... This could also explain the increase in C9, LBP, and SAA1, which decreased after treatment of PMR ( Figure 1A-F). Intriguingly, an autoantibody against PGLYRP2 has been identified as a promising biomarker in RA, especially in early and seronegative patients [36]. The SAA1 protein was more abundant before PMR treatment and, supposedly, has several functions, including acute phase response and chemoattractant activity. ...

... Several groups have tested this therapy to dozens of patients with active RA and observed improvement of articular symptoms. [100][101][102] However, no groups attributed the improvement to the decrease in circulating neutrophils. To decrease circulating neutrophils, anti-IL-17A antibody would also be effective because IL-17A stimulates bone marrow stroma cells to secrete G-CSF. ...

... In fact, the anti-inflammatory functions of T-614 has been elaborated in numerous pathological models [32,33]. It has been reported that T-614 relieves alveolar inflammation and pulmonary fibrosis in bleomycininduced mice [34]. T-614 alleviates the secondary progressive multiple sclerosis in mice by decreasing IL-6 level and Th17 cell migration [35]. ...