Yong Yu's research while affiliated with Southern University of Science and Technology and other places
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Publications (13)
Streptococcus suis is an important zoonotic pathogen, causing cytokine storms of Streptococcal toxic shock‐like syndrome amongst humans after a wound infection into the bloodstream. To overcome the challenges of fever and leukocyte recruitment, invasive S. suis must deploy multiple stress responses forming a network and utilize proteases to degrade...
Integrative and conjugative elements (ICEs) play a vital role in bacterial evolution by carrying essential genes that confer adaptive functions to the host. Despite their importance, the mechanism underlying the stable inheritance of ICEs, which is necessary for the acquisition of new traits in bacteria, remains poorly understood. Here, we identifi...
Significant advancements have been achieved in the field of thermoelectric technology, with a focus on enhancing and broadening its applications for large-scale waste heat
recovery. Studies have sought to obtain room-temperature thermoelectric materials to enhance and expand thermoelectric technology for large-scale waste heat recovery application...
Klebsiella pneumoniae ( K. pneumoniae ) is a major common environmental pathogen which causes bovine mastitis. To investigate the epidemic of K. pneumoniae of China, 131 K. pneumoniae strains were isolated from 495 clinical mastitis milk samples from 14 provinces in China. The isolation rate of K. pneumoniae was 26.5%, and K57 was the dominant sero...
Introduction
Mastitis is one of the most serious diseases affecting dairy farming, causing huge economic losses worldwide. Streptococcus agalactiae is the main pathogenic bacterium of contagious mastitis and can deliver a devastating blow to a farm's economy. Rapid detection is the key to disease control.
Methods
In this study, a rapid detection m...
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Lactococcus garvieae (L. garvieae) is a pathogenic gram-positive, catalase-negative (GPCN) bacterium that causes bovine mastitis. A total of 49 L. garvieae isolates were identified from 1441 clinical mastitis (CM) samples. The pathogenic effects of L. garvieae were studied with two infection models: bovine mammary epithelial cells cultured in vitro...
Streptococcus agalactiae (Group B Streptococcus, GBS) is a multi-host pathogen, even causing life-threatening infections in newborns. Vaccination with GBS crossed serotypes vaccine is one of the best options for long-term infection control. Here we built a comprehensive in silico epitope-prediction workflow pipeline to design a multivalent multiepi...
Streptococcus suis ( S . suis ) is one of the important pathogens that cause bacterial meningitis in pigs and humans. Evading host immune defences and penetrating the blood-brain barrier (BBB) are the preconditions for S . suis to cause meningitis, while the underlying mechanisms during these pathogenic processes are not fully understood. By detect...
Streptococcus suis is an important emerging zoonosis that causes economic losses in the pig industry and severe threats to public health. Transcriptional regulators play essential roles in bacterial adaptation to host environments. In this study, we identified a novel XRE family transcriptional regulator in S. suis CZ130302, XtrSs, involved in the...
Streptococcus suis is an important emerging zoonosis that causes economic losses in the pig industry and severe threats to public health. Transcriptional regulators play essential roles in bacterial adaptation to host environments. In this study, we identified a novel XRE family transcriptional regulator in S. suis CZ130302, XtrSs, involved in the...
Streptococcal infections are very common in humans and animals, and they are usually treated with antibiotics. Multidrug-resistant Streptococcus strains have continuously emerged in recent years, prompting the search for alternatives to antibiotics. The use of endolysins encoded by phages has presented a promising alternative approach to treatment....
Outer membrane proteins (OMPs) of Aeromonas hydrophila have a variety of functional roles in virulence and pathogenesis and represent promising targets for vaccine development. The main objective of this study was to develop an in-silico model of beta-barrel OMP present among the valid A. hydrophila pangenomes (n = 22). With a program named the β-b...
Citations
... For example, the incorporation of the Ag and Se atoms combined with the employing entropy optimization can decrease the thermal conductivity significantly because of the anharmonicity, while the electrical conductivity is retained. [126] Thus, the outstanding power factor is obtained. ...
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... and 20 min for V. v [32,35]. However, recent studies using the MIRA assay have reported that the posi line could be observed after 5 min for S. eriocheiris, A. baumannii, and Streptococcu tiae [33,34,36]. Since the MIRA assay applies a different source of recombinase (Str ces azure recA, SC-recA) compared to the RPA assay that uses the RecA/Rad 51 o of bacteriophage T4, T4 UvsX, this may result in different incubation times for am tion [31]. ...
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... have a similar profile and can be easily misidentified [5,9]. L. garvieae has been reported to cause other infections including mastitis, diverticulitis, peritonitis, infective spondylodiscitis, liver abscess, and urinary tract infections [10]. Raw seafood is thought to be the main source of infection with L. garvieae with unpasteurized dairy products being another [11]. ...
... Hence, in the current study, this receptor was employed as a representative of the immunogenic receptor in the molecular docking determination. Correspondingly, several publications on the multiepitope vaccine-based computational design that represents potential docking with TLR receptors could induce antibody production after in vivo immunization 54,55 . Moreover, the RMSF profiles of the CMEV-TLR4 complexes with an average score of ≤ 4 Å might define their complex stability resulting in stimulating receptor response by fluctuating residues 11,14-56 . ...
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... Human lung adenocarcinoma cells (A549) and human brain microvascular endothelial cells (hBMEC) were used for cell cytotoxicity assays, according to previous reports [26,[44][45][46]. The human isolate ID36054 and four pig isolates 2021WUSS075, 2018WUSS156, ND90, and 2018WUSS160, with a mortality rate of ≥ 80% in zebrafish and mice, were selected for cell cytotoxicity assays. ...
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... Previous studies have shown that transcriptional factors, including SalK/SalR [11], CiaRH [12], and LuxS/AI-2 [13], etc., could help S. suis adapt to different host environments and promote its pathogenicity by regulating the transcription of genes related to virulence and metabolism [14]. Recently, we reported a novel XRE family transcriptional regulator, XtrSs, involved in bacterial adaptation to hydrogen peroxide stress in S. suis CZ130302 [15]. Therefore, further research on the transcriptional regulation of S. suis during infection can provide a deeper explanation of its pathogenic mechanisms. ...
... Ply0643 was discovered in the Streptococcus agalactiae prophage S. a 04 [63]. It consists of a N-terminal glucosaminidase, a C-terminal LysM CBD and a middle position amidase_3, the latter two sharing 61% protein sequence similarity with that of PlySK1249 and PlySs9 (Fig. 4). ...
... To address this, a pangenome approach has been conducted to identify 2202 core genes shared by both ST251 A. hydrophila and ST656 A. dhakensis. As outer membrane/beta-barrel and extracellular/secreted proteins have been promising targets for vaccine development [45,46], a list of outer membrane and extracellular proteins were identified from the core gene subset. Further immunoinformatic analysis and in vitro validation would be necessary to determine a final vaccine against both A. hydrophila and A. dhakensis infections. ...
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