Yixu Jiang's research while affiliated with Jilin University and other places
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Publications (5)
Objectives
To express a TAT-PBX1 fusion protein using a prokaryotic expression system and to explore potential effects of TAT-PBX1 in the proliferation and senescence of human hair follicle-derived mesenchymal stem cells.ResultsThe TAT-PBX1 fusion was produced in inclusion bodies and heterogenously expressed in Rosetta (DE3) cells. Immunofluorescen...
Background:
PBX homeobox 1 (PBX1) is involved in the maintenance of the pluripotency of human embryonic and hematopoietic stem cells; however, the effects of PBX1 in the self-renewal and reprogramming of hair follicle mesenchymal stem cells (HF-MSCs) are unclear. The AKT/glycogen synthase kinase (GSK) 3β pathway regulates cell metabolism, prolifer...
The maintenance of highly proliferative capacity and full differentiation potential is a necessary step in the initiation of stem cell-based regenerative medicine. Our recent study showed that epidermal growth factor (EGF) significantly enhanced hair follicle-derived mesenchymal stem cell (HF-MSC) proliferation while maintaining the multilineage di...
The use of human mesenchymal stem cells (hMSCs) in cell therapies has increased the demand for strategies that allow efficient cell scale-up. Preliminary data on the three-dimensional (3D) spinner culture describing the potential use of microcarriers for hMSCs culture scale-up have been reported. We exploited a rich source of autologous stem cells...
Cyclosporine A (CsA) enhances hair growth through caspase-dependent pathways by retarding anagen-to-catagen phase transition in the hair follicle growth cycle. Whether apoptosis-inducing factor (AIF), a protein that induces caspase-independent apoptosis, can regulate the hair follicle cycle in response to CsA is currently unclear. Here, we show tha...
Citations
... Our research group has also been committed to studying HF development and regeneration. Some of our findings are as follows; Ggene therapy can promote HF proliferation and regulate their cycle processes [157][158][159]. Stem cell-derived exosomes or growth factors promote wound healing and HF proliferation [160,161]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1135635448496128-1647767998265_Q64/Zinan-Liu-9.jpg)
... From extensive previous studies, we already know that PBX1 acts in proliferation in stem cells and during organogenesis [54][55][56][57]. This is a good starting point to make us question whether PBX1 is involved in cancer cell proliferation as well. ...
... Some of our findings are as follows; Ggene therapy can promote HF proliferation and regulate their cycle processes [157][158][159]. Stem cell-derived exosomes or growth factors promote wound healing and HF proliferation [160,161]. HF regeneration can be induced through tissue engineering [162]. HF-induced pluripotent stem cells can be induced through gene reprogramming [157]. ...
... 10 Notably, hair follicle mesenchymal stem cells (HFMSCs) are gradually gaining interest owing to their advantages of abundance, non-invasive and convenient extraction, non-immunogenicity, and rapid proliferation in vitro. 11 HFMSCs express MSCs markers, including CD73, CD90, and CD105, and efficiently differentiate into adipose, bone, cartilage, smooth muscle, nerve, and vascular tissues in vitro. 10 MSCs primarily act through paracrine cytokines, inflammatory factors, and extracellular vesicles (EVs) rather than their differentiation products. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279348398575634-1443613256689_Q64/Wenyue-Jiang.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/452760383561729-1484957895528_Q64/Jin-Liu-71.jpg)
... HF-induced pluripotent stem cells can be induced through gene reprogramming [157]. The HF microenvironment regulates the HF cycle process [163,164]. In the future,we will collaborate with other researchers to resolve the problem of hair loss and ensure sustainable clinical applications of effective therapeutic strategies. ...
