Yiting Song's research while affiliated with First Affiliated Hospital of China Medical University and other places
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Publications (9)
As an iron-dependent regulated form of cell death, ferroptosis is characterized by iron-dependent lipid peroxidation and has been implicated in the occurrence and development of various diseases, including nervous system diseases and injuries. Ferroptosis has become a potential target for intervention in these diseases or injuries in relevant precl...
Aim:
To investigate the hypercoagulability of hepatocellular carcinoma (HCC)-related cerebral infarction (HCRCI) with thromboelastography (TEG).
Methods:
A multicenter prospective study was conducted in HCRCI patients, HCC patients without cerebral infarction, and acute cerebral infarction (ACI) patients without HCC between January 2016 and Dece...
To identify the regulatory network of microRNAs (miRNAs) and mRNAs to clarify molecular mechanisms in stroke. Four miRNA datasets and two mRNA datasets of stroke were downloaded from the GEO database. R-Studio was utilized to analyze differentially expressed miRNAs (DEmiRNAs) and mRNAs (DEmRNAs) in the blood of stroke and control patients. FunRich...
Ferroptosis is a form of regulated cell death that is mainly triggered by iron-dependent lipid peroxidation. A growing body of evidence suggests that ferroptosis is involved in the pathophysiology of traumatic brain injury (TBI), and tropomyosin-related kinase B (TrkB) deficiency would mediate TBI pathologies. As an agonist of TrkB and an immediate...
With the acceleration of population aging, nervous system diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), anxiety, depression, stroke, and traumatic brain injury (TBI) have become a huge burden on families and society. The mechanism of neurological disorders is complex, which also lacks effective tr...
The purpose of this research was to explore the underlying biological processes causing coronavirus disease 2019- (COVID-19-) related stroke. The Gene Expression Omnibus (GEO) database was utilized to obtain four COVID-19 datasets and two stroke datasets. Thereafter, we identified key modules via weighted gene co-expression network analysis, follow...
Objective
To investigate the clinical features, risk factors and underlying pathogenesis of cancer related subarachnoid hemorrhage (SAH).
Methods
Clinical data of SAH in patients with active cancer from January 2010 to December 2020 at four centers were retrospectively reviewed. Patients with active cancer without SAH were matched to SAH patients...
Increasing evidence indicates a possible causal link between neuroinflammation and neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and stroke. A putative mechanism underlying such a link can be explained by ferroptosis. Current studies have shown that disturbances of iron homeostasis,...
Citations
... xCT inhibition also attenuates glutamine metabolism and lowers nutrient flexibility (12). Acyl-CoA synthetase long-chain family member 4 (ACSL4) increases levels of polyunsaturated fatty acids (PUFAs), raising sensitivity to ferroptosis by increasing lipid peroxidation (13). Moreover, high levels of lipid droplets could proportionally elevate susceptibility to ferroptosis because of elevated PUFAs and lipophagy activation (14). ...
... Alvarez-Perez et al., 2012 [51] No non-active cancer group Amiri-Nikpour and Husseinzadeh, 2016 [23] Full text not available Bang et al., 2023 [24] No separate group to answer research question Bonnerot et al., 2016 [25] No non-active cancer group Cen et al., 2023 [26] No non-active cancer group Di Castelnuovo et al., 2014 [27] Patients with coronary artery disease did not answer Ellis et al., 2018 [28] Study does not separately provide D-dimer data in cancer patients Markus, 2020 [29] Editorial Ito et al., 2018 [30] No non-active cancer group Kim et al., 2021 [17] No well-defined cancer and non-cancer groups Kono et al., 2012 [10] Detailed FDP values not available separate for cancer and non-cancer groups Liu et al., 2021 [31] Study does not separately provide D-dimer data in cancer patients Nahab et al., 2020 [32] Study does not separately provide D-dimer data in cancer patients Nakajima et al., 2022 [15] No non-active cancer group Nam et al., 2017 [33] No non-active cancer group Nam et al., 2023 [34] No non-active cancer group Nezu et al., 2018 [35] No non-active cancer group Nickel et al., 2021 [36] Mix of population, no separate cancer group Ohara et al., 2020 [13] Review article Pan et al., 2021 [38] Study does not separately provide D-dimer data in cancer patients Pan et al., 2022 [37] No non-active cancer group Pieper et al., 2000 [39] Mix of population Rodrigues et al., 2014 [40] Conference abstract Rosenberg et al., 2020 [41] Study does not separately provide D-dimer data in cancer patients Ryu et al., 2017 [42] No non-active cancer group Schultz et al., 2022 [43] Conference abstract Shen et al., 2020 [44] Study does not separately provide D-dimer data in cancer patients Tardy et al., 1998 [45] Study does not separately provide D-dimer data in cancer patients Tsushima et al., 2020 [46] No non-active cancer group Wang et al., 2022 [47] No non-active cancer group Wei et al., 2020 [48] No non-active cancer group Yamaguchi et al., 2019 [49] No non-active cancer group Zhang et al., 2019 [50] Systematic review and meta-analyses FDP: Fibrinogen degradation products studies were retrospective. In the present systematic review, 2651 patients with ischemic infarcts are included of which 404 (13.97%) patients had active cancer while 2247 (86.02%) did not. ...
... The N-acetyl-5-hydroxytryptamine (NAS), acting as a TrkB agonist and direct melatonin precursor, exhibits multiple advantageous effects on traumatic brain injury (TBI) [130]. Administration of NAS reduces TBI-induced neurobehavioral deficits, lesion volume, and neurodegeneration. ...
... 27 Multimechanistic pharmacologic interventions for TBI, including antioxidants, antiexcitatory, and anti-inflammatory treatments, as well as combined therapies, have been investigated. [28][29][30][31][32] Combining medications from different classes aims to enhance synergistic effects, yet not all have translated successfully to clinical practice. 33 TBI pathophysiology is complex and evolves over time, requiring adaptable interventions tailored to different stages. ...
... Furthermore, the transcriptomic data showed increased expression of ITGA2B in samples from patients with AF-CE (Fig. 6D, E). It has been documented that ITGA2B is identified as a key gene in covid-19-related stroke and is involved in the integrin signaling pathway, thereby regulating platelet activation, extracellular matrix-(ECM-) receptor interactions, and PI3K-Akt signaling pathway [33]. Based on these results, we hypothesized that HIST1H2BH might be involved in AF-CE thrombus formation by affecting ITGA2B protein transcription. ...
... When administered, Fer-II can reduce the expression of TfR1 in neurons, which helps protect them from damage and neurodegeneration caused by TBI [98]. The molecular mechanism behind Fer-II involves reducing Fe3+ content and iron deposits; reversing the expression of proteins related to iron homeostasis such as R1 and lipid peroxidation genes; and lowering high levels of MDA after TBI [128]. When recombinant Annexin A5 (A5) was administered via the tail vein in TBI mice, it exhibited ameliorative effects on neurological deficits, weight loss, cerebral hypoperfusion, cerebral edema, blood-brain barrier disruption, neuronal apoptosis, and iron-induced cell death. ...
... On further analysis, SAH was the initial presenting sign in 5 out of 40 hematological tumors recruited along a 10-year course reflecting its low probability [10]. ...
... Upon entering the cytoplasm, cystine is quickly converted into cysteine, a significant building block for the production of GSH. Therefore, System X c − is involved in the modulation of GSH synthesis so that GSH can protect cells from oxidative damage [89,90]. Furthermore, when GSH is present, glutathione peroxidase 4 (GPX4), a part of the glutathione peroxidase group, can act as a donor of electrons to transform the unstable lipid hydroperoxide (L-OOH) found in the cell membrane. ...
