Yibin Wang's research while affiliated with Duke-NUS Medical School and other places

... Figure 4B further support that under the background of normal mice, the process of Pg-induced elevated plasma TMAO levels depends more on the oxidation of TMA in the liver rather than the generation of TMA in the intestine. Pg, Fn, and Sm groups exhibited a downregulation in FMO2 gene expression compared to the control group, which potentially indicates a general stress response of the liver to oral pathogenic bacterial infection (Ni et al., 2022). In vitro TMAO exacerbates lipid accumulation, inflammation, and fibrosis in the liver (Vallianou et al., 2019;Carpino et al., 2020). ...

... In such preparations, the preservation of electrical coupling between cells means that electrophysiological recordings reflect the summation of a wider pool of currents which influence the measured membrane potential 26,27 . Additionally, experiments on isolated iPSC-CMs typically involve prolonged periods of culture as single cells 10,22,27 . This is known to promote electrophysiological remodelling in isolated adult CMs and may therefore contribute to the heterogeneity exhibited by isolated iPSC-CMs 28-30 . ...

... Dysregulated mechanistic target of rapamycin (mTOR) and insulin-like growth factor 1 (IGF1) signaling, impaired nutrient sensing, and autophagy are implicated in the pathogenesis of progeroid syndromes, laminopathies, as well as aging in the general population. Genetic and pharmacological inhibition of the mTOR signaling pathways, as well as intermittent fasting and restriction of branched-chain amino acids, are shown to increase life span, including in a mouse model of progeria, and reduce age-related diseases [39][40][41][42][43] . The genome is not only affected by the mutations but also by various endogenous, such as reactive oxygen species, and exogenous, such as ultraviolet light, resulting in various forms of DNA damage, most notably doublestranded DNA breaks (DSBs). ...

... Numerous prior studies have investigated the mRNA and miRNA as integral players in the cardiovascular system's physiological and pathophysiological processes (84,85). It is necessary to investigate further the relationship between SFⅡ helicases (such as Dicer and RHAU) and miRNA and mRNA in mixed primary cardiomyopathies, including DCM. ...

... 185 The RNA splicing regulator RBFOX1 (RNA-binding Fox-1 homolog 1) markedly increases in expression during cardiomyocyte maturation 180,186 and is another potential activator of cardiomyocyte maturation. 187 MicroRNA (miRNA)-based mRNA silencing is another mechanism that modulates gene expression in cardiomyocyte maturation. For example, miR-1, a miRNA enriched in mature cardiomyocytes, facilitated electrophysiological maturation in stem cell-derived cardiomyocytes in vitro. ...