Yi-Meng Gao's research while affiliated with Northeast Forestry University and other places
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Publications (2)
In this study, the beneficial effect of paeonol on acute alcohol-induced liver injury and the basic mechanisms were investigated. in vitro, HepG2 cells were treated with paeonol for 24 h before it were exposed to alcohol for 24 h. in vivo, male C57BL/6 mice were used to establish alcohol-induced liver injury models by oral gavage of alcohol (5 g/kg...
2′-O-galloylhyperin (2′-O-GH), an active compound isolated from Pyrola calliantha, possesses remarkable antioxidant activity. The aims of this study were to investigate the hepatoprotective effect of 2′-O-GH against oxidative stress and elucidate the underlying mechanistic signaling pathways in HepG2 cells as well as in an animal model. Results sho...
Citations
... Studies have shown that the intrarenal inflammation mediated by macrophage activation and toll-like receptors (TLRs) plays an important role in the development and progression of DN [4]. Silent information regulator 1 (SIRT1) / nuclear factor related factor 2 (Nrf2) / nuclear factor-κB (NF-κB) signaling pathways are closely related to inflammation and oxidative stress [5]. Hence, the SIRT1/Nrf2/NF-κB signal may become a potential therapeutic target to inhibit oxidative stress and inflammation, thereby exerting reno-protective effects in DN.At present, few few therapeutic agents directly target the renal and vascular complications of diabetes, and most studies focus on albuminuria. ...
... properties of Nrf2 target genes (Liu et al., 2010;Surh, Kundu, & Na, 2008;Wang et al., 2017), and some studies aimed to investigate the molecular mechanisms involved in this effect. Several signaling pathways play a role in HSC activation, such as TGF-β, Smads and free radicals (Krithika, Jyothilakshmi, & Verma, 2016;Lei et al., 2016). ...
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