Yi Liu's research while affiliated with China Pharmaceutical University and other places

... In biomedicine, these nanoparticles have unique features such as high biocompatibility, low toxicity, water dispersibility, and controlled drug delivery, which enable them to improve the diagnosis and pharmacokinetic properties of drugs over conventional therapies [2,[9][10][11][12]. Particularly, luminescence bioimaging is a common technique for diagnosis purposes, as it offers benefits such as rapid response, high resolution, and sensitivity [13]. Most of the conventional luminescent labels need ultra-violet or short-wavelength radiation to be excited. ...

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Green-emitting lanthanum niobate mesoporous nanospheroids for near-infrared light responsive cancer theranostics

... This innovative approach offers an efficient treatment that addresses wound infection and promotes wound healing simultaneously. 161 Shen et al. (2023) developed an advanced wound dressing by employing a multilayered upconversion nanocomposite. This composite structure featured UCNPs enveloped with a mesoporous silica-loaded zinc phthalocyanine (ZnPc) photosensitizer. ...

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Advancements and Applications of Upconversion Nanoparticles in Wound Dressings

... Enzymes play essential roles in all life processes and are currently considered as the important biomarkers of many diseases, including cancers, Alzheimer's disease and cardiovascular disease. [1] For example, alkaline phosphatase is overexpressed in some bone cancers; [2] nitroreductase is expressed at high levels in solid tumors; [3] the improvement of monoamine oxidase in the brain is usually associated with Parkinson's disease (PD); [4] compared with normal ovaries, the enzyme activity of β-galactosidase (β-gal) is enhanced in primary ovarian cancer. [5] Thus, identifying the location and expression levels of these enzymes would be helpful to better reveal the development of these diseases and monitor the efficacy of therapies. ...

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Quinone Methide Based Self‐Immobilizing Molecular Fluorescent Probes for In Situ Imaging of Enzymes

... Biothiols, such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), are closely related to living organisms and have attracted considerable interest from researchers since their discovery [9][10][11][12]. These three types of amino acids have similar structures, but play different roles in living organisms, including crucial roles in maintaining the normal operation of living organisms [13][14][15]. ...

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Construction and application of copper ion and amino acid probe based on functionalized metal–organic framework probe

... Chlorin e6 4T1 BALB/c Anti-PD-L1 Significantly inhibited tumor growth; CD8 + T cells ↑; [69] Zinc-phthalocyanine B16F10 C57BL/6 Anti-PD-L1 Combined therapy can significantly inhibit tumor growth; CD8 + T cells ↑; [108] Chlorin e6 4T1 BALB/c Anti-PD-L1 Effectively inhibit the growth of primary tumors and metastatic tumors; Tregs ↓; IL-6, IFN-γ and TNF-α ↑; [109] IR780 B16F10 C57BL/6 Anti-PD-L1 Combined therapy can significantly inhibit tumor growth and effectively promote T cell infiltration; [110] ZnF16Pc B16F10 C57BL/6 Anti-PD-L1 Significantly inhibited tumor growth; Memory T cells, CD8 + T cells ↑; Tregs ↓; [111] Fe-TBP CT26 BALB/c Anti-PD-L1 Combined therapy can significantly inhibit tumor growth; CD4 + T cells, CD8 + T cells ↑; [112] Talaporfin MC38 C57BL/6 Anti-PD-L1 Combined therapy inhibited tumor growth on both the unirradiated side and the irradiated side; CD4 + T cells, CD8 + T cells ↑; PD-L1 ↓; [113] PdPc (OBu) 8 4T1 BALB/c Anti-PD-L1 The treatment of PdPc-PDT plus anti-PD-L1 can induce an anti-tumor immune response to delay the growth of primary and distant tumors; CD8 + T cells ↑; [114] PpIX CT26 BALB/c Anti-PD-L1 ...

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Photodynamic Therapy-Induced Anti-Tumor Immunity: Influence Factors and Synergistic Enhancement Strategies

... To evaluate the practical applicability of this PBMO nanoprobe to real samples, AChE content in human serums is detected. The Cys and GSH in human serum have interference in the AChE detection; thus, a thiolblocking reagent, NEM, is added into human serum [35]. It is found that the AChE concentrations presented in the diluted human serums from healthy volunteers are 1.30 ± 0.09, 1.51 ± 0.07, and 1.09 ± 0.06 U L −1 (Table 2), with RSDs of 2.5%, 3.2%, and 2.9%. ...

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Time-resolved fluorescence nanoprobe of acetylcholinesterase based on ZnGeO:Mn luminescence nanorod modified with metal ions

... Photothermal therapy (PTT) holds great potential in cancer therapy owing to the advantages of controllable treatment area, non-invasiveness, and minimal side effects [1]. During the process of PTT, light absorbers are required to convert the incoming light into heat for subsequent cancer cell ablation [2]. ...

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Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy

... Fluorescence imaging technology has became a powerful tool for biological system monitoring, mainly due to the advantages of simple operation, high spatiotemporal resolution, and noninvasive detection [9]. At present, numerous fluorescent probes have been reported for the independent detection of ClO − [10][11][12][13][14][15][16][17] (Table S1), or viscosity [18][19][20][21][22][23][24] (Table S2). However, many of these probes were severely hydrophobic, as a result, required to use a large amount of toxic organic co-solvents [10,11,13,14,16,17]. ...

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A Mitochondria-Targeting Fluorescent Probe for the Dual Sensing of Hypochlorite and Viscosity without Signal Crosstalk in Living Cells and Zebrafish

... In POP@ZIF-8 NPs + Laser + Vc group, Vc solution and NPs solution were injected into mice at the same time to inhibit the production of ROS in vivo, while in POP@ZIF-8 NPs + Laser + cooling group, the treatment temperature was controlled below 40°C to avoid PTT caused by temperature rise [7]. After that, the mice were treated once every two days, and tumor volume and body weight were recorded for 14 days [60][61][62]. After the treatment period, the tumors of the mice were removed for further analysis of the treatment results. ...

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Porphyrin-based porous organic polymer coated ZIF-8 nanoparticles as tumor targeted photosensitizer for combination cancer photodynamic/photothermal therapy

... AChE can decompose the substrate acetylcholine thioate (ATCh) into acetic acid and thiocholine (TCh). The sulfhydryl group (-SH) on TCh with reducing, complexing and strong nucleophile properties, can further react with luminescent substances (fluorescent proteins [17], quantum dots [18,19], metal nanoclusters [20,21], conjugated polymers [22], organic fluorescent dyes [23][24][25], etc.) to produce detectable signals. For such probes, the choice of luminescent material largely determines the biocompatibility and preparation cost. ...

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Two Fluorescent Probes for Recognition of Acetylcholinesterase: Design, Synthesis, and Comparative Evaluation