Yi-Jun Wang's research while affiliated with St. John's University and other places
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Publication (1)
![Figure 3. Effects of SSJ26 and SSJ32 on efflux of [ 3 H ]-paclitaxel. (...](profile/Diaa-Youssef/publication/274961431/figure/fig3/AS:284525247647752@1444847513450/Effects-of-SSJ26-and-SSJ32-on-efflux-of-3-H-paclitaxel-A-The-effect-of-SSJ26_Q320.jpg)
Our previous studies showed that several sipholane triterpenes, sipholenol A, sipholenone E, sipholenol L and siphonellinol D, have potent reversal effect for multidrug resistance (MDR) in cancer cells that overexpressed P-glycoprotein (P-gp/ABCB1). Through comparison of cytotoxicity towards sensitive and multi-drug resistant cell lines, we identif...
Citations
... In further experiment, semisynthetic esters sipholenol A-4-O-acetate and sipholenol A-4-O-isonicotinate were found to effectively reverse P-gp-mediated MDR. ABCB1 gene expression vector transfected in HEK-293 cells was used to examine the effect of sipholane analogs on P-gp.[89] One novel molecule, spongionellol A, and five already known spongian diterpenes derivatives from the deep-water marine sponge Spongionella sp. ...
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