Yi-Jen Liao's research while affiliated with Taipei Medical University and other places
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Publications (62)
The increased proliferation and activation of hepatic stellate cells (HSCs) are associated with liver fibrosis development. To date, there are no FDA-approved drugs for the treatment of liver cirrhosis. Augmentation of HSCs apoptosis is one of the resolutions for liver fibrosis. In this study, we extracted α-mangostin (1,3,6-trihydroxy-7-methoxy-2,...
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor. Although sorafenib and regorafenib have been approved for first-line and second-line treatment, respectively, of patients with advanced HCC, long-term treatment often results in acquired resistance. Given that glycolysis-mediated lactate production can contribute to drug res...
Deep-frying is a common cooking practice worldwide, and after repeated heatings, the oil undergoes various chemical reactions, including hydrolysis, polymerization, lipid oxidation, and the Maillard reaction. Studies have pointed out that oxidized dietary frying oil may cause teratogenesis in mice and increase cancer and cardiovascular risks. The l...
Primary liver cancer is the fifth leading death of cancers in men, and hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancer cases. Sorafenib is a first-line drug for advanced-stage HCC patients. Sorafenib is a multi-target kinase inhibitor that blocks tumor cell proliferation and angiogenesis. Despite sorafenib...
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor in the world. Sorafenib is the first-line drug for patients with advanced HCC. However, long-term treatment with sorafenib often results in reduced sensitivity of tumor cells to the drug, leading to acquired resistance. Identifying biomarkers which can predict the response to...
Persistent chronic liver diseases increase the scar formation and extracellular matrix accumulation that further progress to liver fibrosis and cirrhosis. Nevertheless, there is no antifibrotic therapy to date. The ketogenic diet is composed of high fat, moderate to low-protein, and very low carbohydrate content. It is mainly used in epilepsy and A...
Cell surface glycosylation has been known as an important modification process that can be targeted and manipulated by malignant cells to escape from host immunosurveillance. We previously showed the blood group branched I antigen on the leukemia cell surface can regulate the cell susceptibility against natural killer (NK) cell-mediated cytotoxicit...
Liver fibrosis initiates the progression of cirrhosis, and, finally, hepatocellular carcinoma (HCC). The increased proliferation and activation of hepatic stellate cells (HSCs) are crucial for hepatic fibrogenesis. Paeonol is the major vigorous component of Cortex Moutan, a traditional herbal medicine widely used for treating various diseases. Here...
Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor with limited treatment. The ketogenic diet (KD) emerged as a metabolic therapy for cancer; however, the antitumor effect on HCC remains controversial. We previously reported that the ketogenesis rate-limiting enzyme, 3-hydroxymethylglutaryl-CoA synthase 2 (HMGCS2), was...
Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Sorafenib, a multikinase inhibitor, is the first-line drug approved by the Food and Drug Administration (FDA) for the treatment of patients with advanced HCC. However, most patients who continuously receive sorafenib may acquire resistance to this drug. Therefore, it is imp...
Phthalates are often added to plastic products to increase their flexibility. Di-(2-ethylhexyl) phthalate (DEHP) is one of the most common plasticizers. Previously, a major incident involving phthalate-contaminated foodstuffs occurred, where phthalates were deliberately added to foodstuffs as a substitute for emulsifiers, resulting in a threat to p...
Hepatic stellate cells (HSCs) are the major profibrogenic cells that promote the pathogenesis of liver fibrosis. The crosstalk between transforming growth factor-β1 (TGF-β1) signaling and lipopolysaccharide (LPS)-induced NF-κB signaling plays a critical role in accelerating liver fibrogenesis. Until now, there have been no FDA-approved drug treatme...
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor worldwide; however, the traditional therapeutic approaches and survival rates are still limited. To improve current therapies, it is necessary to investigate the molecular mechanisms underlying liver cancer and to identify potential therapeutic targets. The aims of this study...
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Currently, sorafenib is the standard first-line drug for patients with advanced HCC. However, long-term exposure to sorafenib often results in reduced sensitivity of tumour cells to the drug, leading to acquired resistance. Therefore, developing new compounds to trea...
Transforming growth factor-β (TGF-β) is known to function as a dual role regulatory cytokine for being either a suppresser or promoter during tumor initiation and progression. In solid tumors, TGF-β secreted from tumor microenvironment acts as a suppresser against host immunity, like natural killer (NK) cells, to favor tumor evasion. However, besid...
Trichostatin A (TSA), a hydroxamate histone deacetylase inhibitor, is a compound that has been identified to induce anticancer activity. The aim of the present study was to investigate whether sorafenib, in combination with TSA, was able to augment the anticancer effects of TSA, identifying an optimum treatment time plan and the potential underlyin...
Glycine N-methyltransferase (GNMT) is abundantly expressed in normal livers and plays a protective role against tumor formation. GNMT depletion leads to progression of hepatocellular carcinoma (HCC). In this study, we investigated the activity of ectopic GNMT delivered using recombinant adeno-associated virus (AAV) gene therapy in mouse models of l...
Liver fibrosis is the first step toward the progression to cirrhosis, portal hypertension, and hepatocellular carcinoma. A high-cholesterol diet is associated with liver fibrosis via the accumulation of free cholesterol in hepatic stellate cells (HSCs). Niemann-Pick type C2 (NPC2) plays an important role in the regulation of intracellular free chol...
Altered sialic acid processing that leads to upregulation of cell surface sialylation is recognized as a key change in malignant tissue glycosylation. This cancer-associated hypersialylation directly impacts the signaling interactions between tumor cells and their surrounding microenvironment, especially the interactions mediated by immune cell sur...
This corrects the article DOI: 10.1038/srep13524.
Sarcomatoid hepatocellular carcinoma (SHC) is a rare type of HCC with significantly poorer survival than ordinary HCC. Little is known about the mechanism associated with SHC and its biomarkers and therapy. Here, we established a mouse liver cancer cell line and designated as Ymac-1. A sarcomatous appearance was observed in the allograft tumor aros...
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies and deadliest cancers in the world. Currently, sorafenib is the only drug that has been approved by the U.S. FDA for patients with advanced HCC. However, its improvement on patient outcomes is modest, and the median survival time is only prolonged 2–3 months. In addition, the...
Background:
The aberrant glycosylation on proteins and lipids has been implicated in malignant transformations for promoting the tumorigenesis, metastasis, and evasion from the host immunity. The I-branching β-1,6-N-acetylglucosaminyltransferase, converting the straight i to branched I histo-blood group antigens, reportedly could influence the mig...
The aim of this study was to understand the difference between the measured and calculated irradiation attenuations obtained using two algorithms and to identify the influence of couch attenuation on patient dose verification. We performed eight tests of couch attenuation with two photon energies, two longitudinal couch positions, and two rail posi...
CyberKnife is one of multiple modalities for stereotactic radiosurgery (SRS). Due to the nature of CyberKnife and the characteristics of SRS, dose evaluation of the CyberKnife procedure is critical. A radiophotoluminescent glass dosimeter was used to verify the dose accuracy for the CyberKnife procedure and validate a viable dose verification syste...
The original data of Fig 6 in this study.
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The original data of Fig 4 in this study.
(PDF)
The original data of Fig 3 in this study.
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The original data of Fig 5 in this study.
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The original data of Fig 7 in this study.
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Purpose: Primary hepatocellular carcinoma and metastatic liver tumors are highly malignant tumors in Asia. The incidence of fatal liver cancer is also increasing in the United States. The aim of this study was to establish a spherical tumor model and determine its accuracy in predicting the absorbed dose in yttrium-90 (Y-90) microsphere therapy for...
Background
Glycine N-methyltransferase (GNMT) is abundantly expressed in the normal liver but is down-regulated in liver cancer tissues. GNMT knockout (Gnmt−/−) mice can spontaneously develop chronic hepatitis, fatty liver, and liver cancer. We previously demonstrated that hepatic GNMT is decreased in high-fat-diet-induced type 2 diabetes mellitus,...
Background:
Phosphorylation status of the transcription factor CCAAT/enhancer binding protein α (C/EBPα) has been demonstrated in a human hematopoietic cell model to regulate the formation of branched I antigen by affecting its binding affinity to the promoter region of the IGnTC gene during erythroid and granulocytic differentiation.
Study desig...
In chronic liver diseases, regardless of their etiology, the development of fibrosis is the first step toward the progression to cirrhosis, portal hypertension, and hepatocellular carcinoma. Hepatic stellate cells (HSCs) are the main profibrogenic cells that promote the pathogenesis of liver fibrosis, and so it is important to identify the molecule...
Hepatits B virus (HBV) is an infectious disease, which can cause acute and chronic infections. Every year, an over 7.5 million person dies due to HBV. No effective drug exists for the treatment of HBV. Hepatits B virus (HBV) is an infectious disease, which can cause acute and chronic infections. Every year, an over 7.5 million person dies due to HB...
Applicators containing metal have been widely used in recent years when applying brachytherapy to patients with cervical cancer. However, the high dose rate (HDR) treatment-planning system (TPS) that is currently used in brachytherapy still assumes that the treatment environment constitutes a homogeneous water medium and does not include a dose cor...
Soluble epoxide hydrolase (sEH) has C-terminal epoxide hydrolase and N-terminal lipid phosphatase activity. Its hydrolase activity is associated with endothelial nitric oxide synthase (eNOS) dysfunction. However, little is known about the role of sEH phosphatase in regulating eNOS activity. Simvastatin, a clinical lipid-lowering drug, also has a pl...
Primary hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related death. It is important to identify new targets for early diagnosis and treatment of HCC. Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding...
This study explores how the metal materials of the applicator influence the dose distribution when performing brachytherapy for cervical cancer. A pinpoint ionization chamber, Monte Carlo code MCNPX, and treatment planning system are used to evaluate the dose distribution for a single Ir-192 source positioned in the tandem and ovoid. For dose distr...
Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. However, little is known about the significance of NPC2 in cancer. In this study, we have pinpointed the impact of various different cancers on NPC2 expression. A series of anti-NPC2 monoclonal ant...
Glycine N-methyltransferase (GNMT) is a tumor suppressor of hepatocellular carcinoma (HCC). High proportions of GNMT knockout mice developed HCC. We previously identified a potential novel marker from Gnmt knockout mice, FK506 binding protein 11 (FKBP11). Here, we determined the clinical usefulness of FKBP11.
FKBP11 expression levels were analyzed...
The decoy receptor 3 (DcR3) is a member of the tumor necrosis factor receptor (TNFR) super-family. It counteracts the biological effects of Fas ligands and inhibits apoptosis. The goals of this study were to understand the associations between serologic DcR3 (sDcR3) levels and different human immunodeficiency virus type 1 (HIV-1) subtypes, as well...
Dose distributions of (192)Ir HDR brachytherapy in phantoms simulating water, bone, lung tissue, water-lung and bone-lung interfaces using the Monte Carlo codes EGS4, FLUKA and MCNP4C are reported. Experiments were designed to gather point dose measurements to verify the Monte Carlo results using Gafchromic film, radiophotoluminescent glass dosimet...
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder with excess accumulation of lipid within hepatocyte. Severe NAFLD is associated with inflammation and contributes to the development of hepatocellular carcinoma (HCC). Previously, we reported that glycine N-methyltransferase knockout (Gnmt-/-) mice develop chronic hepatitis and HCC....
The mechanism underlying the dysregulation of cholesterol metabolism and inflammation in atherogenesis is not understood fully. Glycine N-methyltransferase (GNMT) has been implicated in hepatic lipid metabolism and the pathogenesis of liver diseases. However, little is known about the significance of GNMT in atherosclerosis. We showed the predomina...
Nonalcoholic fatty liver disease (NAFLD) is associated with the development of metabolic syndromes and hepatocellular carcinoma (HCC). Cholesterol accumulation is related to NAFLD, whereas its detailed mechanism is not fully understood. Previously, we reported that glycine N-methyltransferase (GNMT) knockout (Gnmt(-/-)) mice develop chronic hepatit...
The radiation dosimetric systems have been developed for more than 50 years and are applied in the measurement of clinical and environment radiation dose. However, most of dosimeters can not repeat reading again in single radiation exposure. According to our previous study, radiophotoluminescent glass dosimeter (RPLGD) has good physical characteris...
Stereotactic radiosurgery (SRS) is designed for patients with small lesion areas that are not suitable for actual surgery.
SRS delivers high dose to the lesion with high gradient on the irradiation margin area. In this study, radiophotoluminescent
glass dosemeter (RPLGD) and radiochromic film were used to measure the output factor of a gamma knife....
In both humans and rodents, males are known to be more susceptible than females to hepatocarcinogenesis. We have previously reported that glycine N-methyltransferase (GNMT) interacts with aflatoxin B(1) (AFB(1)) and reduces both AFB(1)-DNA adduct formation and hepatocellular carcinoma (HCC) in mice. We also reported that 50% of the males and 100% o...
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC
In both humans and rodents, males are known to be more susceptible than females to hepatocarcinogenesis. We have previously reported that glycine N-methyltransferase (GNMT) interacts with aflatoxin B1 (AFB1) and reduces both AFB1-DNA adduct formation and hepatocellular c...
Previously, we reported that glycine N-methyltransferase (GNMT) interacts with benzo[a]pyrene (BaP) and inhibits BaP-DNA adducts formation. In addition, Gnmt knockout (Gnmt(-/-)) mice developed chronic hepatitis and hepatocellular carcinoma (HCC). The aims of this study were to understand the gene expression profile of Gnmt(-/-) mice and to study t...
Thermoluminescent dosimeters are widely applied in the measurement of radiation dose. Since the luminescent centers are not lost during the reading process, radiophotoluminescent glass dosimeters (RPLGDs) can be repeatedly readout. The aims of this study were to make RPLGD and to analyze its physical and chemical properties. This study used chemica...
Hepatocellular carcinoma (HCC) is the fifth common cancer in the world and it mainly occurs in men. Glycine N-methyltransferase (GNMT) participates in one-carbon metabolism and affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine. Previously, we described that the expression of GNMT was diminished in huma...
Citations
... Pedraza-Chaverriet al (2009) reported the antioxidant potency of α-mangostin towards mitochondrial toxin 3-nitropropionic acid (3-NP) [4]. Furthermore, its potential renoprotection [5], curing acute renal injury by inhibiting reactive oxygen species (ROS) production of the dead cells [6], and as a therapeutic agent against liver fibrosis [7] has been studied. However, as they are derived from natural resources, harvest seasons and climate may affect α-mangostin content and possibly lead to varying quantity levels. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/753595943235584-1556682682365_Q64/Chun-Ya-Lee.jpg)
... Markedly elevated serum LDH levels, but of low diagnostic value HCC Increased lactate levels. Accumulation of lactate in the TME (9,56,57,76,108,(117)(118)(119)(120)(121)(122)(123)128,129,(133)(134)(135)(136)(137)(138)(139)(140)(141)(142) could lead to acidification of the extracellular environment, which can inhibit the function of T cells and NK cells, and enhance the immunosuppressive function of TAMs, MDSCs and regulatory T cells thereby promoting tumor progression. Increased lactate levels along with increased drug resistance in HCC. ...
... Cooking exposes palm oil to heat, which causes it to enter the body in an oxidized form. High-temperature (180°C) oil releases products known as oxygen derivatives and free radicals, which harm bodily tissues and can lead to the development of brosis in the liver tissue [7]. Hot oil is a common item in the food industry and is used daily by families and food vendors [8]. ...
... In contrast, KCNG1, a gene involved in fatty acid metabolism (FAM), has a strong correlation with the prognosis of head and neck squamous cell carcinoma (31). HMGCS2, also known as 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2, is a key ketogenic enzyme responsible for facilitating ketone production and regulating tumor proliferation and metastasis (26,44). The close association of these genes with radiosensitivity in CC and their underlying mechanisms, calls for additional in-depth research and investigation. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1001870235545600-1615875886084_Q64/Wan-Chun-Chiu.jpg)
... On the contrary, studies have shown that independent of cholesterol metabolism, downregulation of NPC2 can activate MAPK/ERK and is associated with poor clinicopathological features. NPC2 is also involved in the induction and maintenance of autophagy, thus playing a protective factor in tumor growth 35 . In addition, NPCs are signi cantly correlated with immune T cells such as Th1, Th2, CD4_T, and CD8_T, and NPC2 secreted by tumors can inhibit the recruitment of immature macrophages to the tumor microenvironment and play a role in inhibiting tumor growth 36 . ...
... This disease can reduce the overall function of the liver-block hepatic blood flow, inhibit liver regeneration, and affect the liver's ability to detoxify, store energy, and clear infections (2). If not properly managed, HF can progress to cirrhosis, eventually increasing the chances of developing liver cancer (3). Regardless of the main cause, liver fibrosis causes a higher mortality rate (4). ...
... GCNT2 has been widely studied in melanoma, the loss of which brings corresponding loss of I-antigen and thus enhances melanoma growth and metastasis [65]. Importantly, many studies have pointed out that the high level of I-antigen synthesized by GCNT2 could increase the susceptibility of malignant cells against immune cells in leukemia [66,67]. This kind of immune regulatory may account for why GCNT2 was upregulated in OC but a good prognostic predictor in our study. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281090185275-1665986057167_Q64/Hui-Yu-Chuang.jpg)
... Western blotting was performed as previously described [54]. The following antibodies were used in the experiment: anti-α-SMA antibody ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/814453524283392-1571192260548_Q64/Chao-Lien-Liu.jpg)
... HMGCS2 is a key enzyme in ketogenesis, and several previous studies have suggested an inhibitory effect on tumor growth, migration, and angiogenesis through ketone synthesis in mitochondria. [25][26][27][28][29][30][31] Low HMGCS2 expression is a poor prognostic factor in colorectal cancer, esophageal squamous cell carcinoma, prostate cancer, and hepatocellular carcinoma. 28,29,32,33 Ketone production by HMGCS2 is generally considered to be an inhibitory regulatory mechanism in tumors. ...
... [13] In addition, the recent studies demonstrated that novel barbituric acid derivatives inhibited the development of hepatocellular carcinoma, which is the most common type of primary liver cancer as shown in Figure 1c. [14][15] ...
