Yaru Zhou's research while affiliated with Capital Medical University and other places
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Publications (5)
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Background:
Diabetes is an independent risk factor of frailty, which increases adverse outcomes in patients with diabetes. Metformin is a common antidiabetic drug in clinical practice. Insulin resistance and chronic inflammation are the two common mechanisms of diabetes and frailty, as well as the main targets of metformin. Research suggested that...
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Background:
Frailty and obesity are associated with poor outcomes in older adults. Previous studies have shown that excessive visceral fat leads to frailty by promoting inflammation. However, the association between visceral fat obesity (VFO) and frailty has not been elucidated. We aimed to investigate the correlation between VFO and frailty in mi...
The global increase in the aging population is expected to result in a shift from disease-centered to function-centered approaches in response to intensive aging. Thus, the World Health Organization (WHO) has proposed a novel concept, intrinsic capacity (IC), which refers to the combination of one's physical and mental abilities. The IC framework c...
Citations
... Even though only intensive lifestyle interventions reduced frailty prevalence among frail diabetic patients and metformin use was not associated with significant reduction (124), administration of extended-release metformin in frail women with concomitant diabetes and hypertension ameliorated cognitive performance (125). In line with this finding, during a 4-year follow-up study, metformin use was associated with a reduction of frailty risk (126). ...
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... Growing evidence, including our previous research [8,9], suggests that high adiposity, assessed by anthropometric measures such as body mass index (BMI) and waist circumference (WC) [10][11][12][13][14], as well as dualenergy X-ray absorptiometry (DXA)-derived measures such as fat mass index (FMI) and visceral adipose tissue (VAT) mass [14][15][16][17][18][19], is an important risk factor for pre-frailty and frailty. Given the rising obesity epidemic across all age groups [20], this is of major concern. ...
... The World Health Organization (WHO) published the Integrated Care for Older People (ICOPE) framework to guide the assessment and promotion of the intrinsic capacity of older people, which refers to the combination of physical and mental capabilities 31 . The domains assessed are cognition, mobility, psychological functions, vitality and sensory 32 . Evidence suggests that impairment of intrinsic capacity is prevalent in community-dwelling older people, particularly in locomotor and cognitive capacity 31,32 . ...
