Yang Yang's research while affiliated with Guangzhou Medical University and other places
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Publications (621)
The purpose of this study was to identify the mechanisms underlying the involvement of glycolytic genes in pulmonary arterial hypertension (PAH). This study involved downloading 3 datasets from the GEO database at the National Center for Biotechnology Information. The datasets were processed to obtain expression matrices for analysis. Genes involve...
Ovarian cancer (OC) is the third most common malignant tumor of women and is accompanied by an alteration of systemic metabolism. A liquid biopsy that captures and detects tumor-related biomarkers in body fluids has great potential for OC diagnosis. Exosomes, nanosized extracellular vesicles found in the blood, have been proposed as promising bioma...
Background
Comparative investigations evaluating the efficacy of pomalidomide‐based (Pom‐based) versus daratumumab‐based (Dara‐based) therapies in patients with relapsed/refractory multiple myeloma (RRMM) remain scarce, both in randomized controlled trials and real‐world studies.
Methods
This retrospective cohort study included 140 RRMM patients t...
Background
The relationship between body composition and the risk of overt hepatic encephalopathy (OHE) following transjugular intrahepatic portosystemic shunt (TIPS) needs to be investigated.
Methods
Overall, 571 patients from 5 medical centers were included. To assess body compositions, we evaluated skeletal muscle indices, adipose tissue indice...
Objective
Ciprofol is a new sedative anesthetic drug that can be used for gastrointestinal endoscopy and induction of general anesthesia, but the appropriate dosage for use in elderly patients has not been determined. Sufentanil is a commonly used opioid in clinical practice, and this study was designed to induce anesthesia in elderly patients usin...
The transnasal endoscopic approach is increasingly used for resection of tumors that are located inferiorly and medially within the orbit. However, this usually requires multiple-handed manipulations, which demand a second corridor for an assistant. Here, we introduce a simple transseptal corridor from the contra-nare, to facilitate assistant instr...
SPARC is an acidic, cysteine-rich, calcium-binding member of the non-collagen glycoproteins originating in bone. Although implicated in the development of several cancers, the functions and mechanisms of SPARC remain unclear. The aim of this study was to investigate whether smooth muscle cell (SMC)-associated SPARC acts an important tumour suppress...
Background
Fournier's gangrene (FG) is a severe form of necrotizing fasciitis primarily caused by gram-negative bacteria. FG can rapidly progress to septic shock, resulting in high mortality rates. In the past, the management of the inflammatory response caused by gram-negative bacteria has been limited. Continuous Veno-Venous Hemofiltration with o...
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Background: Gastric or gastroesophageal junction (G/GEJ) adenocarcinoma is one of the most common lethal malignancies in the world. Near half of the G/GEJ adenocarcinoma are locally advanced at diagnosis and with poor prognosis. Several clinical trials including SHARED (ChiCTR1900024428), which conducted in our center, demonstrated that perioperati...
Diabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one of the most serious chronic heart diseases and has become a major cause of heart failure worldwide. At present, the pathogenesis of DCM is unclear, and there is still a lack of effective therapeutics. Previous studies have shown that the homeostasis of mitoch...
Background:
Upstream stimulating factor 2 (USF2) belongs to basic-Helix-Loop-Helix-Leucine Zipper transcription factor family, regulating expression of genes involved in immune response or energy metabolism network. Role of USF2 in neuropathic pain was evaluated.
Methods:
Mice were intraspinally injected with adenovirus for knockdown of USF2 (Ad...
AML1/ETO fusion confers favorable prognosis in acute myeloid leukemia (AML) treated with intensive chemotherapy (IC). However, the impact of AML1/ETO fusion on the efficacy of venetoclax in the treatment of AML is unclear.
The aim of this study was to evaluate the efficacy of venetoclax plus hypomethylating agents (VEN/HMAs) in patients with AML1/E...
Objectives
Since neither abdominal pain nor pancreatic enzyme elevation is specific for acute pancreatitis (AP), the diagnosis of AP in patients with pancreaticobiliary maljunction (PBM) may be challenging when the pancreas appears normal or nonobvious on computed tomography (CT). This study aimed to develop a quantitative radiomics-based nomogram...
Background
Inflammatory factors are associated with depression. We seek to investigate the correlation between inflammatory cytokines and prognosis of depression or suicidal ideation and behavior at 3 months in depression patients.
Methods
Eighty-two depressed outpatients were recruited and treated as usual. Plasma cytokines were measured at basel...
The efficient utilization of small-diameter shrub resources holds significant potential in averting forest resource
waste and mitigating carbon emissions. Herein, glueless biocomposites were prepared using waste smalldiameter
Buxus megistophylla via alkali pre-treatment and thermal molding. Instead of simple hot-pressing, the biocomposites were pre...
Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the nasopharyngeal epithelial cells. Common treatment methods for NPC include radiotherapy, chemotherapy, and surgical intervention. Despite these approaches, the prognosis for NPC remains poor due to treatment resistance and recurrence. Hence, there is a crucial need for more com...
Objective
The relationship between skeletal muscle and adipose tissue compositions and risk of overt hepatic encephalopathy (OHE) following transjugular intrahepatic portosystemic shunt (TIPS) treatment needs to be investigated.
Methods
A total of 282 patients were collected from two medical centres. The median time of follow-up was 48.23 + 1.36 m...
Using updated National Health and Nutrition Examination Survey (NHANES) follow-up data, and a large nationwide representative sample of adult U.S. citizens, the aim of this study was to explore the relationship between dietary flavonol intake, all-cause and cause-specific mortality risks. In this prospective cohort study based on NHANES (2007–2008,...
Background
Neuromyelitis optica spectrum disorder (NMOSD) associated with cognitive impairment (CI) is acknowledged. However, the underlying pathogenesis and involvement of the immune system remain unclear.
Objectives
This study aimed to investigate the alterations in immune cells, cytokines, and GABA⁺ levels in NMOSD patients with cognitive defic...
Precise identification of lymph node metastases is vital for the management of cervical cancer. However, the existing diagnostic methods for lymph node metastases have certain drawbacks. In this study, we aim to explore the expression of cancer-associated fibroblasts (CAFs) and tumor-to-stroma CD8+ T cells ratio (CD8+ T cells T:S ratio) and its ass...
Background
Acute lung injury (ALI)/severe acute respiratory distress syndrome (ARDS) is a serious clinical syndrome characterized by a high mortality rate. The pathophysiological mechanisms underlying ALI/ARDS remain incompletely understood. Considering the crucial role of immune infiltration and macrophage polarization in the pathogenesis of ALI/A...
Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age, leading to continuous heart failure, even in people without a prior history of heart disease. To address this issue and improve cardiac cell function, it is crucial to investigate the molecular mechanisms un...
Matrix metalloproteinase 9 (MMP9) plays a pivotal role in mammary ductal morphogenesis, angiogenesis and glandular tissue architecture remodeling. However, the molecular mechanism of MMP9 expression in mammary epithelial cells of dairy cows remains unclear. This study aimed to explore the underlying mechanism of MMP9 expression. In this study, to d...
Purpose
To assess the performance of radiomics-based analysis of contrast-enhanced computerized tomography (CE-CT) images for distinguishing GS from gastric GIST.
Methods
Forty-nine patients with GS and two hundred fifty-three with GIST were enrolled in this retrospective study. CT features were evaluated by two associate chief radiologists. Radio...
The collective total syntheses of (±)‐hosieines A–C with a cage‐like tetracyclic framework have been realized, which includes the first syntheses of hosieines B‐C. The key strategy of the synthesis employs a one‐pot domino reaction that involves Cu‐catalyzed [3+2] cycloaddition, 1,6‐enone formation, and 1,6‐aza‐Michael addition forming the 5/6/6‐az...
In order to improve the interfacial properties of rotary welding of wood, additive pre-treatments for wooden tenons were conducted as follows: immersion in oleic acid-modified calcium carbonate whiskers (group CA), no treatment (group DZ), immersion in CuSO 4 and Na 2 SO 3 for a duration of 8 hours (group CN), and addition of calcium carbonate in t...
Background
A minute fraction of patients stands to derive substantial benefits from immunotherapy, primarily attributable to immune evasion. Our objective was to formulate a predictive signature rooted in genes associated with cytotoxic T lymphocyte evasion (CERGs), with the aim of predicting outcomes and discerning immunotherapeutic response in co...
Background
The cochlear sympathetic system plays a key role in auditory function and susceptibility to noise-induced hearing loss (NIHL). The formation of reactive oxygen species (ROS) is a well-documented process in NIHL. In this study, we aimed at investigating the effects of a superior cervical ganglionectomy (SCGx) on NIHL in Sprague-Dawley rat...
Rationale
Pure white cell aplasia (PWCA) is a rare paraneoplastic syndrome that occurs in patients with thymomas. Currently, the pathogenesis and treatment of this disease remain in the exploratory stage.
Patient concerns
We report a 68-year-old woman with thymoma experienced PWCA involvement as her first presentation. The patient had high fever a...
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with ~50 million people experiencing TBI each year. Ferroptosis, a form of regulated cell death triggered by iron ion-catalyzed and reactive oxygen species-induced lipid peroxidation, has been identified as a potential contributor to traumatic central nervous system...
An 11-year-old boy presented with progressive unilateral skin hardening on his right thigh and buttock for 7 years. What is your diagnosis?
Introduction
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with elevated bile acids in the blood. Diagnosis typically only occurs after the manifestation of clinical symptoms and the metabolic mechanisms underlying its development remain unclear. The aim of this study was to investigate potential speci...
Cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. Iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage an...
Background
The dynamic interaction between cancer cells and tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is an active barrier to the effector arm of the antitumour immune response. Cancer-secreted exosomes are emerging mediators of this cancer-stromal cross-talk in the TME; however, the mechanisms underlying thi...
Introduction
Monochorionic, diamniotic (MCDA) monozygotic twins share nearly all genetic variation and a common placenta in utero. Despite this, MCDA twins are often discordant for a range of common phenotypes, including early growth and birth weight. As such, MCDA twins represent a unique model to explore variation in early growth attributable pri...
Background
The mortality rate of acute respiratory distress syndrome (ARDS) increases with age (≥ 65 years old) in critically ill patients, and it is necessary to prevent mortality in elderly patients with ARDS in the intensive care unit (ICU). Among the potential risk factors, dynamic subphenotypes of respiratory rate (RR), heart rate (HR), and re...
The first asymmetric total syntheses of (+)-pancratinines B and C and total syntheses of (−)-montanine, (−)-pancracine and (−)-brunsvigine were realized in a divergent fashion. Our synthetic strategy features a copper-catalyzed [3 + 2] annulation reaction and a Pictet–Spengler cyclization.
Background: T cells are crucial components of antitumor immunity. A list of genes associated with T cell proliferation was recently identified; however, the impact of T cell proliferation-related genes (TRGs) on the prognosis and therapeutic responses of patients with colorectal cancer (CRC) remains unclear.
Methods: 33 TRG expression information a...
Wogonin, extracted from the roots of Scutellaria baicalensis Georgi, has been shown to suppress collagen deposition in spontaneously hypertensive rats (SHRs). This study was performed to investigate the role and mechanism of wogonin underlying vascular remodeling in SHRs. After injection of SHRs with 40 mg/kg of wogonin, blood pressure in rats was...
It is well known that bone‐related diseases are difficult to treat due to the relatively low blood flow. Therefore, targeting the delivery of drugs to bone may not only improve the therapeutic effect but also reduce the dose. To prepare liposomes, a series of novel multivalent glutamic hexapeptide derivatives were designed and synthesized as liposo...
Erythropoiesis-stimulating agents (ESAs) have played an important role in the treatment of renal anemia in children, but cannot improve hemoglobin to target level in some cases. Roxadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, can stimulate endogenous erythropoietin production and regulate iron metabolism even in patients with k...
The aim of this case–control study was to explore the potential risk factors for venous ulceration in patients with varicose veins of lower extremities and to establish a simplified diagnostic score model. Seventy subjects with varicose veins of lower extremities and venous ulceration were compared with 1164 controls with varicose veins of lower ex...
This study proposes a novel method for generating virtual orbital angular momentum (OAM) using a synthetic uniform circular array (SUCA). In the proposed method, the base array is rotated to various spatial locations, with the feeding phases modified accordingly, and the generated fields at various spatial locations are superimposed. The proposed m...
Background and Aims
The transjugular intrahepatic portosystemic shunt has controversial survival benefits; thus, patient screening should be performed preoperatively. In this study, we aimed to develop a model to predict post‐transjugular intrahepatic portosystemic shunt mortality to aid clinical decision making.
Methods
A total of 811 patients un...
Globally, ischemic stroke causes millions of deaths per year. The outcomes of ischemic stroke are largely determined by the amount of ischemia-related and reperfusion-related neuronal death in the infarct region. In the infarct region, cell injuries follow either the regulated pathway involving precise signaling cascades, such as apoptosis and auto...
Lysophosphatidic acid (LPA) is an active phospholipid signaling molecule that binds to six specific G protein-coupled receptors (LPA 1-6 ) on the cell surface and exerts a variety of biological functions, including cell migration and proliferation, morphological changes, and anti-apoptosis. The earliest study from our group demonstrated that LPA tr...
Objective:
Heme oxygenase-1 (HO-1) is a protein involved in the inflammatory response following ischemia-reperfusion injury (IRI). Evidence suggests that pyroptosis plays an important role in IRI. However, the underlying mechanism between HO-1 and pyroptosis in IRI requires further investigation.
Methods:
Using the "two-cuff" method, a Sprague D...
Bronchial lipoma is a rare benign tumor of the lung, which is often misdiagnosed due to concomitant pulmonary diseases. In addition, the coexistence of endobronchial lipoma and lung cancer is extremely unusual. To date, no related computed tomography (CT) images have been reported. The patient was a 53-year-old man, who was admitted to our hospital...
Intraoperative radiotherapy (IORT) is a precise, single high‑dose irradiation directly targeting the tumor bed during surgery. In comparison with traditional external beam RT, it minimizes damage to other normal tissues, ensures an adequate dose to the tumor bed and results in improved cosmetic outcomes and quality of life. Furthermore, IORT offers...
![Fig. 1. Signal transducer and activator of transcription (STAT) [54]....](profile/Mohammad-Reza-Mohammadi-10/publication/374870535/figure/fig1/AS:11431281200343035@1697833820303/Signal-transducer-and-activator-of-transcription-STAT-54-This-figure-is-licensed_Q320.jpg)
Introduction
: Even after the introduction of extracorporeal cardiopulmonary resuscitation (ECPR), clinical prognosis following cardiac arrest (CA) remains poor. Post-cardiac arrest syndrome (PCAS) may contribute to cardiovascular instability and death after ECPR. Systemic inflammation constitutes is a significant component of PCAS, and the severit...
(1) Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that threatens the population health of older adults. However, the mechanisms of the altered metabolism involved in AD pathology are poorly understood. The aim of the study was to identify the potential biomarkers of AD and discover the metabolomic changes produced...
Aim
This study aimed to explore whether the addition of sarcopenia and visceral adiposity could improve the accuracy of model predicting progression-free survival (PFS) in hepatocellular carcinoma (HCC).
Methods
In total, 394 patients with HCC from five hospitals were divided into the training and external validation datasets. Patients were initia...
Purpose
Precise identification of lymph node metastases is vital for the management of cervical cancer. However, the existing diagnostic methods for lymph node metastases have certain drawbacks. In this study, we aim to explore the expression of cancer-associated fibroblasts (CAFs) and tumor-to-stroma CD8⁺ T cells ratio (CD8⁺ T cells T:S ratio) and...
Objective : To characterize the metabolic variation in neonatal hair samples associated with intrauterine growth discordance in dichorionic-diamniotic (DCDA) twins and to evaluate the effects of specific metabolic alterations on later neurobehavioural outcomes in infancy. Design: Cohort-based case-control study Setting: Peking University Third Hosp...
This study aimed to retrospectively evaluate the treatment strategies and possible prognostic factors in patients with brain metastases (BMs) from esophageal squamous cell carcinoma (ESCC). We retrospectively reviewed 30 patients with BMs from ESCC who were treated at our center between November 2011 and January 2022. Clinicopathological characteri...
Background
Remimazolam tosilate (RT) is a novel ultrashort-acting γ-aminobutyric acid subtype A (GABAA) agonist, with several advantages including rapid induction and recovery, stable haemodynamics, and mild respiratory inhibition. However, studies have not been conducted to explore the haemodynamic effects of RT in elderly hypertensive subjects un...
Simple Summary
Our study aims to understand the impact of acetate intervention at the systemic level before a short period of cold exposure on brown adipose tissue in mice. The results show that acetate may demonstrate a synergistic effect with cold exposure to induce obvious transcriptional changes in brown adipose tissue. These analyses provided...
The current methods for the prediction of mortality and amputation for inpatients with diabetic foot (DF) use only conventional, simple variables, which limits their performance. Here, we used a random survival forest (RSF) model and multicomponent variables to improve the prediction of mortality and amputation for these patients. We performed a re...
An M-type hexaferrite is a material with rich physical characteristics, such as magnetism, the dielectric property, and the magnetodielectric (MD) effect. In this paper, we systematically investigated the magnetic, dielectric, and MD properties of BaFe12−xMexO19 (Me = Ga and In; x=0.0, 1.2, 1.8, and 2.4) ceramics prepared by a solid-state reaction...
A Cu-catalyzed diastereoselective [3 + 2] cycloaddition of 2-arylaziridines and cyclic silyl dienol ethers was developed to efficiently construct fused-[5,n] carbocyclic pyrrolidines, which are widespread in bioactive natural products. Mechanistic studies revealed that the high diastereoselectivity of this transformation arose from a sequential ret...
Objective: Ciprofol combined with sufentanil was used to explore median effective dose and 95% confidence interval for inhibiting the upper gastrointestinal endoscopic insertion response in elderly patients using up-and-down sequential allocation trial, provide a reference for clinical rational drug use. Methods: We studied fifty-seven patients who...
Background
Increasing evidences prove the encouraging efficacy of neoadjuvant immunochemotherapy for esophageal squamous cell carcinoma (ESCC). However, the safety of chemotherapy is still unsatisfactory. Previous studies have confirmed the good efficacy and tolerance of camrelizumab (PD-1 inhibitor) combined with apatinib (angiogenesis inhibitor)...
Background
Pancreaticobiliary maljunction (PBM) is a congenital defect, with risk of developing various pancreaticobiliary and hepatic complications. The presentations of PBM in children and adults are believed to be different, but studies on PBM children of different age groups are limited. This study was to evaluate clinicopathologic characterist...
Diabetic kidney disease (DKD) is a global health issue that presents a complex pathogenesis and limited treatment options. To provide guidance for precise therapies, it is crucial to accurately identify the pathogenesis of DKD. Several studies have recognized that mitochondrial and endoplasmic reticulum (ER) dysfunction are key drivers of the patho...
In this multicenter, single-arm phase 2 trial (ChiCTR1900024428), patients with locally advanced gastric/gastroesophageal junction cancers receive one cycle of sintilimab (anti-PD1) and chemotherapy (S-1 and nab-paclitaxel), followed by 5 weeks of concurrent chemoradiotherapy and sintilimab, and another cycle of sintilimab and chemotherapy thereaft...
Copper (Cu) is a vital trace element for maintaining human health. Current evidence suggests that genes responsible for regulating copper influx and detoxification help preserve its homeostasis. Adequate Cu levels sustain normal cardiac and blood vessel activity by maintaining mitochondrial function. Cuproptosis, unlike other forms of cell death, i...
Lots of adrenergic receptors (ARs) are widely present across the auditory pathways and are positioned to affect auditory and vestibular functions. However, noradrenergic regulation in the cochlea has not been well characterized. In this study, a rat model of noise-induced hearing loss was developed to investigate the expression of α2A-adrenergic re...
Globally, 265,713,467 confirmed cases of SARS-CoV-2 (CoV-2), including 5,260,888 deaths, have been reported by the WHO. It is important to study the mechanism of this infectious disease. A variety of evidences show the potential association between CoV-2 and glucose metabolism. Notably, people with type 2 diabetes mellitus (T2DM) and other metaboli...
Background & aims:
Exposure to a range of elements, air pollution, and specific dietary components in pregnancy has variously been associated with gestational diabetes mellitus (GDM) risk or infant neurodevelopmental problems. We measured a range of pregnancy exposures in maternal hair and/or infant cord serum and tested their relationship to GDM...
Background:
Lymphoid-specific helicase (HELLS), a SNF2-like chromatin-remodeling enzyme, plays a key role in tumor progression via its DNA methylation function. However, the effects of HELLS on immune infiltration and prognosis in liver hepatocellular carcinoma (LIHC) remain uncertain.
Methods:
The Tumor Immune Estimation Resource (TIMER) databa...
Background
Bladder cancer is one of the most common malignant tumors of the urinary system and is associated with a poor prognosis once invasion and distant metastases occur. Epithelial-mesenchymal transition (EMT) drives metastasis and invasion in bladder cancer. Transforming growth factor β1 (TGF-β1) and stromal fibroblasts, especially cancer-ass...
Ferroptosis is an iron-dependent programmed cell death pattern that is characterized by iron overload, reactive oxygen species (ROS) accumulation and lipid peroxidation. Growing viewpoints support that the imbalance of iron homeostasis and the disturbance of lipid metabolism contribute to tissue or organ injury in various kidney diseases by trigger...
Background
Monochorionic (MC) twins present a higher incidence of unfavorable clinical perinatal outcomes than dichorionic (DC) twins, often in association with placental vascular anastomosis. In this study, we profiled the umbilical cord plasma metabolomes of uncomplicated MC and DC twin pregnancies and related these to several offspring outcomes,...
Objective
To compare the recent efficacy and safety of different Amplatzer models and similar occluder in the treatment of patent foramen ovale (PFO).
Methods
Patients with PFO complicated with cryptogenic stroke or migraine who underwent transcatheter closure of PFO in the First Affiliated Hospital of Nanjing Medical University from September 201...
Backgroud
To predict the malignancy of 1–5 cm gastric gastrointestinal stromal tumors (GISTs) by machine learning (ML) on CT images using three models - Logistic Regression (LR), Decision Tree (DT) and Gradient Boosting Decision Tree (GBDT).
Methods
231 patients from Center 1 were randomly assigned into the training cohort (n = 161) and the intern...
Chemotherapy can induce a robust T cell antitumor immune response by triggering immunogenic cell death (ICD), a process in which tumor cells convert from nonimmunogenic to immunogenic forms. However, the antitumor immune response of ICD remains limited due to the low immunogenicity of tumor cells and the immunosuppressive tumor microenvironment. Al...
Citations
... Calcium homeostasis plays a crucial role in various metabolic and cardiovascular processes. Recent studies highlight its involvement in the pathogenesis of cardiovascular diseases by mitochondria, particularly in the context of DM and its associated glycemic traits [36]. On the other hand, DM and its related glycemic conditions are well-documented risk factors for cardiovascular diseases, including CAC and CAVS [5]. ...
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... Our recent in vitro data have shown that PD-L1 expression is activated in BMDMs as early as 2 hours after S. aureus infection [16], but the present study has found that robust expression of SLC7A11 appears after 12 hours of infection, it is reasonable to postulate that these two molecules might play distinct roles in initiation and potentiation of the suppressive effect on ROS levels, respectively, in the context of persistent S. aureus infection. Recent studies have highlighted PD-L1 as a negative regulator of M1 polarization and the secretion of proinflammatory cytokines in macrophages, processes associated with ROS production and NF-κB pathway activation [40,41]. While we did not assess the effect of SLC7A11 and PD-L1 on macrophage polarization, both our present and previous work [16] have demonstrated their inhibitory effects on ROS production and the NF-κB pathway in S. aureus-infected BMDMs. ...
... and cancer-related mortality (0.45, 0.28-0.70) [33]. In summary, our findings are partially different from the studies mentioned above, probably due to differences in the study populations. ...
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... Senescence is usually considered a state of cell cycle arrest; however, as cardiomyocytes are terminally differentiated, they must be considered differently [96]. Senescent cardiomyocytes exhibit functional alterations (dysregulated contraction, irregular shortening, elevated pacing frequency), structural alterations (enlarged size, mitochondrial dysfunction, shortened telomeres) and production of factors affecting neighbouring cells (SASP: senescence-associated secreting phenotype) [97]. ...
... Moreover, contrast-enhanced computed tomography (CE-CT) imaging can be used to distinguish stomach gastrointestinal cancers (GISTs) from gastric schwannomas (GSs). Delong's test revealed no statistically significant differences in the prediction performance between the clinical and radiomic data models [10]. ...
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... ZNF385A has been identi ed as a gene associated with lymphatic vessel formation in CRC, in uencing immune cell in ltration, and is also associated with an immunosuppressive phenotype in HCC 41,42 . G0S2 is linked to evasion from cytotoxic T lymphocytes and knocking down G0S2 signi cantly inhibits proliferation and migration of CRC cell lines 43 . TAP1, a transporter associated with antigen processing protein, plays a crucial role in antigen presentation 44 , and its downregulation in colorectal cancer is associated with low in ltration of various lymphocytes 45 Subsequently, we constructed a risk model of T cell-related genes (TRGS) using these six genes, and patients were strati ed into high-risk and low-risk groups based on the median TRGS value. ...
... Hair has been found to reflect the serum metabolome [23], essentially acting as a temporal record of a patient's metabolic characteristics by widening the inspection window and overcoming the transient nature of tissue, fluid, and exhaled breath metabolomes. However, untargeted metabolomics of hair to identify novel biomarkers of disease is underutilized, with studies having investigated pregnancy pathologies [24][25][26][27][28][29][30], drug addiction [31][32][33], and cervical cancer [34]. Here, a machine learning methodology is developed and validated to analyze a novel source of metabolites obtained from human hair specimens. ...
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... Identi ed risk factors for varicose veins encompass aging, pregnancy, obesity, and height [10,25]. Notably, obesity not only markedly elevates the risk of lower extremity varicose veins but also escalates the incidence of related complications [18,31]. Furthermore, obesity may mask the symptoms of varicose veins, thereby delaying treatment seeking. ...
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... The Chinese Collaboration Group on the Acute Variceal Bleeding & predicting the treatment effect (CCG-AVB-TEP1) model proposed by Han [13] was based on non-TIPS cohorts (cirrhosis related AVB who were treated with endoscopy plus drug), and validated by small sample of preemptive-TIPS cohorts. The model MT proposed by Zhao [14] didn't analyze the etiology distinction. And both models were used for predicting short-term survival after TIPS placement. ...
... It is likely that these substances are present everywhere to varying extents and concentrations, and the awareness of their presence depends on which chemical substance laboratories focus on identifying in the water/environment. The toxicity of drugs, especially endocrine disruptors, has recently become the subject of scientific debate and a global public health problem, primarily because of their individual or synergistic effects on humans and the ecosystem (Trapido et al. 2014;Barton-Maclaren et al. 2022;Wu et al. 2023;Dalamaga et al. 2024;He et al. 2024). These substances cause dysfunction of the endocrine system, manifesting in a variety of diseases, including developmental and metabolic disorders (Schneider et al. 2019;Robles-Matos et al. 2021;He et al. 2024). ...
