Ya-Zhen Li's research while affiliated with China Medical University (ROC) and other places
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Publications (2)
Background: Pulmonary fibrosis features in damaged pulmonary structure or over-produced extracellular matrix and impaired lung function, leading to respiratory failure and eventually death. Fibrotic lungs are characterized by the secretion of pro-fibrotic factors, transformation of fibroblasts to myofibroblasts, and accumulation of matrix proteins....
Imperatorin is one of the furanocoumarin derivatives and exists in many medicinal herbs with anticancer, antiviral, antibacterial, and antihypertensive activities. In this study, we examined the anti-inflammatory effects of imperatorin on inflammation-associated lung diseases. Imperatorin reduced iNOS and COX-2 expression and also IL-6 and TNFα pro...
Citations
... Research on alveolar macrophages has demonstrated that compound (2) can efficiently inhibit the synthesis of signaling molecules and pro-inflammatory chemicals. Furthermore, it has been noted that this compound also prevents pro-inflammatory pathways from being activated, particularly the NF-κB and Janus kinase 1/signal transducer and activator of transcription 3 (JAK1/STAT3) pathways [115]. Compound (2) was found to be able to stimulate the human pregnane X receptor (PXR) in an investigation by Liu et al. [116]. ...
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