Y. Oguma's research while affiliated with Kindai University and other places

... In this aspect, and as seen in our results, Ra-223 can be administered as early as first line as soon as bone metastasis is confirmed, or at 10 later lines (e.g. third line, i.e. previously mCRPC treated patients), and also in either the pre-or post-chemotherapy setting [30,31]. Previously reported mean (SD) CTSQ total scores for SWT, ET and FSE domains are as follows, respectively: 72.0 (16.0), 64.1 (17.0), 47.2 (19.1), in European metastatic hormone-sensitive prostate cancer (mHSPC) patient [32]; 69.4 (15.4), 60.6 (21.0) and 54.9 (17.5), respectively in European and US HR +/HER2metastatic breast cancer patients [33], and 79.7 (13.9), 55.6 (22.5) and 52.2 (23.8), respectively in European patients with stage IIIB and IV non-squamous non-small-cell lung carcinoma treated with pemetrexed [20]. ...

... Although there was wide variation in reported incidence, recent high-quality evidence suggests a rate of 40-50% for all patients with head and neck cancer receiving radiotherapy (Figure 1). Some investigations suggest that RT-induced hypothyroidism occurs relatively shortly after RT (e.g., within months), but others suggest that changes in function may occur for multiple years following treatment [43,44]. Many studies identified clinical and treatment-related factors that predict an increased risk of hypothyroidism, including female sex, decreased thyroid volume, and receipt of multimodality therapy. ...

... LDH, thought to be indicative of more aggressive cancers that can proliferate under hypoxic conditions (Uehara et al. 2021), is the key enzyme in anaerobic glycolysis, which is accomplished by transforming pyruvate into lactate. An analysis of three selected studies revealed that higher LDH levels were correlated with inferior OS outcomes and worse PFS outcomes (Figs. 5 and 6) (HR = 4.87, 95% CI = 2.85-8.35, ...

... for radical radiation therapy in ESCA using conventional radiotherapy 14 . However, with the advancement of radiation technology, such as intensity modulated radiation therapy (IMRT) or three-dimensional conformal radiation therapy (3DCRT), which offer better conformality and allow for the delivery of higher radiation doses to the target area without causing additional toxicities 15 , more and more physicians have been exploring the use of higher radiation doses to achieve improved outcomes. Recent published randomized controlled studies have indicated that the e cacy of standard radiation dose is equivalent to doses of 60Gy or higher, even when modern radiation techniques are employed [16][17][18] . ...