Y.-M. Shen's scientific contributions
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Publications (4)
β-Elemene, (55, 7R, 105)-(-)-(1-methyl-1-vinyl-2, 4-diisopropenyl-cyclohexane) is an anticancer agent from the Traditional Chinese Herb Medicinal. Accordingly, we synthesized β-Elemene-TEG-Re (CO)3 complexe and evaluated it as a potential radiopharmaceuticals. The structures and properties of the intermediate were indentified via IR, 1H NMR and HRM...
Starting from the Traditional Chinese Medicine β-elemene, a new kind of β-elemene tricarbonyl rhenium complex was prepared via halogenation and nucleophilic substitution reactions, followed by reaction with tricarbonyl rhenium. Under the similar reaction conditions, the radioactive β-elemene tricarbonyl rhenium complex was synthesized. All the comp...
A series of β-elemene monosubstituted polyethylene glycol (PEG) derivatives were prepared by the reaction of β-elemene with aminated PEG and characterized by IR, 1H NMR and 13C NMR spectra. Their in vitro antiproliferative activities towards K562 cell and Hela cell lines were evaluated by a WST-1 method, showing that their antiproliferative activit...
Aim: To design and synthesize a series of β-elemene amine derivatives in order to investigate their in vitro antitumor activity. Methods: The target compounds were synthesized via nucleophilic substitution. Their antitumor activity in vitro were evaluated by WST-1 method. Results: Eight new target compounds were synthesized. Their structures were c...
