Y. Huang's research while affiliated with Heinrich-Heine-Universität Düsseldorf and other places

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Publications (23)


Focal grey matter heterotopias in monozygotic twins with developmental language disorder
  • Article

November 1998

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16 Reads

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12 Citations

European Journal of Pediatrics

S Preis

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Y Huang

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We describe 9-year-old monozygotic male twins with a developmental language disorder of the phonologic-syntactic type and learning difficulties. High-resolution MRI revealed bilateral parieto-temporal grey matter heterotopias in both twins, on the left more than on the right, and more pronounced in the more affected twin. This suggests a causal relationship between the heterotopias and the neuropsychological findings in this twin pair. Conclusion Neuronal migration defects and ensuing focal heterotopias may be causally related to developmental language disorders.

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Normal intrasylvian anatomical asymmetry in children with developmental language disorder

October 1998

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14 Reads

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77 Citations

Neuropsychologia

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P Schittler

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Symmetry of posterior intrasylvian cortices (e.g., planum temporale, planum parietale) has been suggested to represent a risk factor for developmental disorders of language and reading. Using high-resolution magnetic resonance morphometry, we studied 21 right-handed children with developmental language disorder of the phonologic-syntactic type, and found normal left-right asymmetry of the planum temporale and planum parietale when compared with 21 matched controls. The planum temporale was bilaterally smaller in the affected children, a finding accounted for by their approximately 7% smaller forebrain size. Our data do not support a role of gross visible unilateral or bilateral abnormalities of posterior intrasylvian ontogenesis in this disorder.


Unsolved Problems in Comparing Brain Sizes in Homo Sapiens

August 1998

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46 Reads

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133 Citations

Brain and Cognition

When brain size is compared across taxonomic levels, there is a clear relation between body parameters and brain size. It is generally stated that the correlation between brain size and body parameters becomes very small at the species level (Aboitiz, 1996), but this is not the case for Homo sapiens where there is a strong correlation between brain size and body size across racial groups that differ in body size. The control for body size across racial groups (and sexes) is rendered difficult because bodies do not just differ only in height and weight. Within groups different studies show weak and inconsistent brain size/body height correlations. A better understanding of brain size/body height relations must await better quality data and a better understanding of how exactly body parameters should be scaled between groups and sexes. We attribute the clear between-group and weak within-group correlations to the large variety of body sizes and body types in our species, a variety which is only equalled in selectively bred species of animals. At present, there is no meaningful basis for the comparison of brain sizes within and between racial groups and sexes.


Figure 1. Anatomical subdivision of the corpus callosum (CC) used in the present study: parallel to the bicommissural line (AC–PC) the maximum anterior–posterior length of the CC is determined and divided into four subareas as demonstrated (1, anterior third; 2, middle third; 3, isthmus; 4, splenium).  
Figure 2. Corpus callosum (CC) areas and forebrain volume (FBV). Unfilled circles indicate women, and filled squares men. Regression slopes for women are dashed.
Figure 3. Corpus callosum (CC) ratios and forebrain volume (FBV). Unfilled circles indicate women, and filled squares men. Regression slopes for women are dashed.  
Figure 4. Mean corpus callosum (CC) ratios for women (F) and men (M). Vertical bars indicate 95% confidence intervals.  
The relationship between corpus callosum size and forebrain volume
  • Article
  • Full-text available

November 1996

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232 Reads

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200 Citations

Cerebral Cortex

Using high-resolution in vivo magnetic resonance morphometry we measured forebrain volume (FBV), midsagittal size of the corpus callosum (CC) and four CC subareas in 120 young and healthy adults (49 women, 71 men). We found moderate linear and quadratic correlations, indicating that the CC and all CC subareas increase with FBV both in men and women (multiple r2 ranging from 0.10 to 0.28). Allometric equations revealed that these increases were less than proportional to FBV (r2 ranging from 0.02 to 0.30). Absolute CC measurements, as well as CC subareas relative to total CC or FBV (the latter measures termed the CC ratios), were further analyzed with regard to possible effects of handedness, gender, or handedness by gender interaction. Contrary to previous reports, left-handers did not show larger CC measurements compared to right-handers. The only apparent influence of gender was on the CC ratios, which were larger in women. However, smaller brains had larger CC ratios which were mainly independent of gender, a result of the less than proportional increase of callosal size with FBV. We suggest that the previously described gender differences in CC anatomy may be better explained by an underlying effect of brain size, with larger brains having relatively smaller callosa. This lends empirical support to the hypothesis that brain size may be an important factor influencing interhemispheric connectivity and lateralization.

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Citations (15)


... In aggiunta al ruolo nell'elaborazione degli stimoli musicali con valenza emotiva (Altenmüller et al. 2014), è possibile anche riconoscere nei musicisti professionisti una differenza cerebellare rispetto agli individui senza formazione musicale. Lo studio con magnetoencefalografia (MEG) di Schneider e colleghi (2002), ad esempio, ha rilevato delle configurazioni peculiari nel cervello dei musicisti, osservando una correlazione dell'attivazione della corteccia uditiva primaria e del volume della materia grigia della porzione anteromediale del giro di Heschl con l'attitudine «Illuminazioni» (ISSN: 2037-609X), n. 64, aprile-giugno 2023 91 musicale; sono stati riscontrati, inoltre, incrementi a carico del corpo calloso (Schlaug et al. 1995) e della corteccia motoria (Stewart 2008). In aggiunta a tali differenze, il ruolo del cervelletto nei musicisti e, in particolare, nella relativa expertise, è stato investigato da diversi studi. ...

Reference:

Oltre il movimento: il contributo cerebellare alle funzioni linguistiche e cognitive
Increased corpus callosum size in musicians.

Neuropsychologia

... If at all avoidable, presumed homogeneous distributions should not be included in any attempts at modelling (and thus, correcting) the PET signal. For practical purposes, however, homogeneity assumptions are adopted in different forms by [11] for PET correction and deconvolution, and [12] for PET simulation (a process applied to [13] and [14]). Improving the assumptions requires a better knowledge of the emission source, where it is very difficult to avoid generalisations. ...

High Resolution PET Images through REDISTRIBUTION
  • Citing Chapter
  • January 1993

... Using 3-D medical software package (CyberMed, Korea) used in a previous study (19), brain tissue on the MR images were separated from non-brain tissue (skull and meninges) for whole brain and cerebellar volumetric measurement. Threshold and region-growing technique were applied to generate a new image, representing brain without any scalp and skull (20,21). Manual tracing was used to eliminate any remaining meninges. ...

Segmentation of MR images for partial-volume-effect correction and individual integration with PET images of the human brain
  • Citing Article
  • January 1993

... Perhaps, Oliver Sacks was right in noting that the gift of absolute hearing might differ from "normal 951 talents" by being a "savant talent"-a precocious ability to process complex tasks in "functional isolation" 952 from conceptual, verbal and even general musical powers, independent of training and practicing music 953 (Sacks 1995). In this respect, absolute pitch might be the backbone of the "savant syndrome" that affects 954 many extremely talented musicians who display signs of "low-functioning autism" (Sacks 2008). ...

Musical Ability

Science

... Affen (Nudo et al. 1992. Unterstützt werden diese Befunde von bildgebenden Untersuchungen des Menschen bei langsam wachsenden Hirntumoren des präzentralen Gyrus, subkortikalen Läsionen des motorischen efferenten Systems und Erkrankungen der motorischen Neurone, bei denen der Nachweis abnormal lokalisierter Aktivierungen innerhalb des präzentralen Gyrus als Ausdruck der stattgehabten Reorganisation gelang (Wunderlich et al. 1996, Kew et al. 1993, Rijntes et al. 1997 (Bütefisch et al. 1995 Hirninfarkt. Patienten, die ein mentales Trainingsprogramm mit "motor imagery" erhielten, zeigten eine deutliche Verbesserung im Ablauf von Greifbewegungen der paretischen Extremität (Miltner et al. 1999). ...

Shift of motor hand representation in precentral gliomas: Evidence from positron emission tomography and neurophysiology
  • Citing Article
  • June 1996

NeuroImage

... Using interhemispheric asymmetry ratios, Breier et al. [9] reported effects of duration of epilepsy on the whole temporal lobe glucose metabolism and blood flow. Although hemispheric asymmetry indices of hippocampal volume and glucose metabolism are positively correlated [14], glucose metabolism does not depend linearly on hippocampal volume [1,41]. Therefore it is of interest to know whether the duration of TLE affects these measures. ...

Focus localization in temporal lobe epilepsy using FDG-PET and volumetric 3D-FLASH-MRI
  • Citing Article
  • June 1996

NeuroImage

... The same values were obtained by Gjedde et al. (1980) in rats. The lower values found in mixed tissue can be explained by the effect of applying a single compartment model to heterogenous tissue (Iida et al., 1989;Lammertsma et al., 1990;Herzog et al., 1993). ...

Comparison of intersubject averaging and individual response identification for mapping of motor function in the human brain with positron emission tomography (PET
  • Citing Chapter
  • January 1993

... The present study did not find significant differences in the length, height, and surface area of the isthmi between males and females. However, Steinmetz and co-authors [37] found that females have a larger proportional isthmus segment of the CC. This may reflect a sex-specific difference in the inter-hemispheric connectivity and functional organization of the temporoparietal association cortex [37]. ...

Sex but no hand difference in the isthmus of the corpus callosum
  • Citing Article
  • May 1992

Neurology

... Given the unsatisfactory effects of conventional drug therapy on clinical symptoms and the lack of more effective individualized therapeutic methods, elucidating the neural mechanisms underlying these syndromes is crucial for developing more effective and targeted treatments [Bogousslavsky et al., 1988;Hosomi et al., 2015;Klit et al., 2009;Wu et al., 2019;Chen Ye et al., 2022]. Advanced neuroimaging techniques, such as functional magnetic resonance imaging (fMRI) [Bonkhoff et al., 2020[Bonkhoff et al., , 2021He et al., 2021;Salvalaggio et al., 2020;Wang et al., 2021], diffusion tensor imaging (DTI) Jang et al., 2019;Li et al., 2011;Nemati et al., 2022] and positron emission tomography (PET) [Dieterich et al., 2005;Dieterich & Brandt, 2008;Kopelman, 2015;Rudolphi-Solero et al., 2022;Stenset et al., 2007;Weder et al., 1994;Willoch et al., 2004], have made important contributions to our understanding of these mechanisms. Thalamic infarction can lead to structural and functional changes in the brain, including altered white matter integrity [Chuo Li, 2011;Krause et al., 2012], cortical reorganization [He et al., 2021;Krause et al., 2014;Wang et al., 2021], and even brain network dysfunction [Favaretto et al., 2022;He et al., 2021;Hosomi et al., 2015;Wang et al., 2021]. ...

Tactile exploration of shape after subcortical ischaemic infarction studied with PET
  • Citing Article
  • July 1994

Brain