Xuhong Yan's research while affiliated with Henan Provincial People’s Hospital and other places

Objective: The objective of this study was to determine the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in assessing postoperative changes in intracranial gliomas. Method: A total of fifty-one patients who had new enhanced lesions after surgical resection followed by standard radiotherapy and chemotherapy were collected retrospectively from October 2014 to June 2021. The patients were divided into a pseudoprogression group (15 cases) and a recurrence group (36 cases) according to the pathological results of the second operation or a follow-up of more than six months. The follow-up data of all patients were complete, and DCE-MRI was performed. The images were processed to obtain the quantitative parameters K trans, Ve, and Kep and the semiquantitative parameter iAUC, which were analysed with relevant statistical software. Results: First, the difference in K trans and iAUC values between the two groups was statistically significant (P < 0.05), and the difference in Ve and Kep values was not statistically significant (P > 0.05). Second, by comparing the area under the curve, threshold, sensitivity and specificity of K trans, and iAUC, it was found that the iAUC threshold value was slightly higher than that of K trans, and the specificity of K trans was equal to that of iAUC, while the area under the curve and sensitivity of K trans were higher than those of iAUC. Third, K trans and iAUC had high accuracy in diagnosing recurrence and pseudoprogression, and K trans had higher accuracy than iAUC. Conclusion: In this study, DCE-MRI has a certain diagnostic value in the early differentiation of recurrence and pseudoprogression, offering a new method for the diagnosis and assessment of gliomas after surgery.

BACKGROUND Background: Intracranial gliomas is the most common primary malignant tumor, accounting for about half of all the primary malignant tumors in the brain, with a high rate of disability and death. Because of the invasive growth of gliomas, it is difficult to completely distinguish the boundaries of tumor removal and the sensitivity of radiotherapy and chemotherapy is not high, so most patients have poor prognosis. However, with the development of radiotherapy technology and the development of new chemotherapy drugs, the prognosis of glioma patients has improved to some extent, but the situation is still not optimistic. At present, the pathogenesis of glioma is not clear, so it is one of the most difficult to treat tumors, with high mortality, recurrence rate and low cure rate. OBJECTIVE Objective: The objective is to study the medical monitoring data of dynamic contrast enhanced intelligent information image with MR in postoperative infection of intracranial gliomas. METHODS Methods: Forty-nine patients who undergo total resection of gliomas in our hospital are selected as the subjects of this study. The subjects are divided into two groups: pseudo progression group (14 cases) and recurrence group (35 cases). All patients have complete follow-up data, and all patients undergo MRI. The acquired MRI images are processed and analyzed, and the quantitative parameters Ktrans, Ve, Kep and semi quantitative parameters iAUC of DCE-MRI images are obtained. Statistical analysis software is used to analyze these values. RESULTS Results: The values of Ktrans and iAUC in the pseudo progression group are significantly lower than those in the recurrence group (P < 0.05). There is no significant difference in Ve and Kep between the two groups (P > 0.05). The value of Ktrans and iAUC in DCE-MRI images have a certain effect on the diagnosis of intracranial gliomas after operation, and the accuracy of Ktrans is higher than iAUC. CONCLUSIONS Conclusion: In this study, the DCE-MRI image has a certain diagnostic value in this respect, which provides a basis for the intelligent diagnosis and treatment of specific conditions after surgery, and has a certain value in improving the prognosis of intracranial glioma.