Xueyan Zhao's research while affiliated with National Cerebral and Cardiovascular Center and other places
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Publications (102)
Aims Although serum uric acid (SUA) is a risk factor for cardiometabolic outcome, but it remains unclear which patients with coronary artery disease (CAD) benefit the most from SUA lowering therapy (ULT). The association of SUA level, systemic inflammation and cardiometabolic risk is still unclear. The current study is aimed to examine whether SUA-...
Aims
Risk assessment for triple-vessel disease (TVD) remain challenging. Stress hyperglycemia represents the regulation of glucose metabolism in response to stress, and stress hyperglycemia ratio (SHR) is recently found to reflect true acute hyperglycemic status. This study aimed to evaluate the prognostic value of SHR and its role in risk stratifi...
Percutaneous coronary intervention (PCI) patients combined with thrombocytopenia (TP) are usually considered to be at low ischemic risk, receiving less proper antiplatelet therapy. However, recent studies reported a paradoxical phenomenon that PCI patients with TP were prone to experience thrombotic events, while the mechanisms and future treatment...
Background
The clinically meaningful cardiac troponin I (cTnI) threshold associated with the long-term prognosis in patients undergoing elective percutaneous coronary intervention (PCI) is still debated.
Objective
To assess the association between different thresholds for post-procedural cTnI and 5-year mortality.
Methods
The study included 4059...
Background and hypothesis
lipoprotein(a) [Lp(a)] and renal dysfunction are both independent risk factors for cardiovascular disease. However, it remains unclear whether renal function mediates the association between Lp(a) and cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI).
Methods
From a large prospective...
Background
Coronary artery calcification (CAC) is a highly specific marker of atherosclerosis. Niemann-Pick C1-like 1 (NPC1L1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are the therapeutic targets of ezetimibe and statins, respectively, which are important for the progression of atherosclerosis. However, CAC’s genetic susceptibili...
Background
Insulin resistance is a pivotal risk factor for cardiovascular diseases, and the triglyceride-glucose (TyG) index is a well-established surrogate of insulin resistance. This study aimed to investigate the prognostic value of the TyG index and its ability in therapy guidance in patients with three-vessel disease (TVD).
Methods
A total of...
Background: Although some studies have shown that the risk of adverse events associated with lipoprotein (a) [Lp(a)] are influenced by low-density lipoprotein cholesterol (LDL-C) or high-sensitivity C-reactive protein (hs-CRP) levels, results on whether hs-CRP and LDL-C jointly mediate the effect of Lp(a) on long-term outcomes are unknown.
Aim: To...
Background: Glasgow Prognostic Score (GPS) is an inflammatory score commonly used in clinical practice. In recent years, its modified scores have emerged, including modified GPS (mGPS) and hs-CRP-modified GPS (hs-mGPS). However, the long-term predictive values of these three scores (GPS, mGPS, and hs-mGPS) in coronary heart disease (CHD) remains un...
Introduction: Recently, growing attention has shifted to apolipoprotein A-I (ApoA-I), revealing compelling relationship between low ApoA-I and ischemia risk. Diabetes mellitus (DM) frequently coexists with abnormal ApoA-I levels. However, the association between ApoA-I and ischemia risk under different diabetes statuses in patients undergoing percu...
Introduction: Individualized antithrombotic therapy guided by platelet function testing is a hot topic in current study. However, the prognostic value of platelet function testing for long-term ischemic events in percutaneous coronary intervention (PCI) population is still unknown.
Objective: To investigate whether platelet function testing (reflec...
Background:
Limited data are available on the long-term impact of mild renal dysfunction (eGFR 60-89 ml/min/1.73m2) in patients with three-vessel coronary disease (3VD).
Methods:
A total of 5,272 patients with 3VD undergoing revascularization were included and were categorized into 3 groups: normal renal function (eGFR ≥90 ml/min/1.73m2, n=2352)...
The value of platelet function test in timing of cardiac surgery remains uncertain. Researches on correlation between Platelet Function Analyzer 200 (PFA-200) and bleeding after elective cardiac surgery are still inadequate. The objective of this study was to investigate the predictive value of PFA-200 in blood transfusion after cardiac surgery. A...
Context:
The association between free fatty acids (FFAs) and unfavorable clinical outcomes has been reported in the general population. However, evidence in the secondary prevention population is relatively scarce.
Objective:
We aimed to examine the relationship between FFA and cardiovascular risk in patients with coronary artery disease (CAD)....
Background
Residual thrombosis risk is an important contributor to ischemic events in patients with Acute Coronary Syndrome (ACS) after Percutaneous Coronary Intervention (PCI). Although previous studies have shown that rivaroxaban 2.5mg twice daily in ACS patients with high ischemic risk can significantly reduce the risk of ischemic recurrence and...
This study was aimed to investigate the association between remnant cholesterol (RC) and low-density lipoprotein cholesterol (LDL-C) concentrations and long-term bleeding. A total of 10,724 consecutive patients who underwent percutaneous coronary intervention in 2013 were prospectively enrolled. During a median follow-up of 5.1 years, 411 bleeding...
Background: Bivalirudin reduces ischemic and hemorrhagic events in patients undergoing primary percutaneous coronary intervention (PCI), but the safety and efficacy for such individuals are unclear. Our aim was to evaluate the long-term safety and efficacy of bivalirudin in patients undergoing elective PCI. Methods: We examined 957 patients with bi...
Background Lipoprotein(a), or Lp(a), has been recognized as a strong risk factor for atherosclerotic cardiovascular disease. However, the relationship between Lp(a) and bleeding remains indistinct, especially in the secondary prevention population of coronary artery disease (CAD). This investigation aimed to evaluate the association of Lp(a) with l...
Background
To investigate the association of HMGCR and NPC1L1 gene polymorphisms with residual cholesterol risk (RCR) in patients with premature triple-vessel disease (PTVD).
Methods
Three SNPs within HMGCR including rs12916, rs2303151, and rs4629571, and four SNPs within NPC1L1 including rs11763759, rs4720470, rs2072183, and rs2073547 were genoty...
Introduction:
Current guidelines recommend moderate-intensity lipid lowering (low-density lipoprotein cholesterol, LDL-C of <2.6 mmol/L or 30%-49% reduction from the baseline) for patients with intermediate 10-year atherosclerotic cardiovascular disease (ASCVD) risk. The effects of intensive lipid lowering (LDL-C of <1.8 mmol/L) on coronary athero...
To reduce cardiovascular risk in patients with established coronary heart disease, the present study investigated the combined effect of D-dimer, high-sensitivity C-reactive protein (hs-CRP), and lipoprotein(a) [Lp(a)] on long-term cardiovascular outcomes from the perspectives of thrombosis, inflammation, and lipid risk simultaneously. Consecutive...
Background:
Risk assessment and treatment stratification for three-vessel coronary disease (TVD) remain challenging. This study aimed to investigate the prognostic value of left atrial volume index (LAVI) with the Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score II, and its association with the long-...
Aim: The dual-antiplatelet therapy (DAPT) score is recommended for predicting the risk of ischemia and bleeding for patients undergoing percutaneous coronary intervention (PCI). This study aimed to investigate the long-term prognostic value of the DAPT score in older PCI patients.
Methods: This study enrolled 10,724 consecutive patients who underwe...
Background
Prediction of bleeding is critical for acute myocardial infarction (AMI) patients after percutaneous coronary intervention (PCI). Machine learning methods can automatically select the combination of the important features and learn their underlying relationship with the outcome.
Objectives
We aimed to evaluate the predictive value of ma...
- [...]
Background:
There are few data comparing clinical outcomes of complex percutaneous coronary intervention (CPCI) when using biodegradable polymer drug-eluting stents (BP-DES) or second-generation durable polymer drug-eluting stents (DP-DES). The purpose of this study was to investigate the safety and efficacy of BP-DES and compare that with DP-DES...
Background
Patients with coronary artery disease (CAD) combined with diabetes have a higher risk of cardiovascular events, and high-sensitivity C-reactive protein (hs-CRP)-to-albumin ratio (CAR) is a novel inflammatory biomarker. However, whether the CAR can identify high-risk patients with CAD and type 2 diabetes (T2DM) remains unclear.
Methods
T...
Background and aims:
Risk stratification for three-vessel coronary artery disease (3VD) remains an important clinical challenge. In this study, we utilized machine learning (ML), which can address the limitations of traditional regression-based models, to develop a novel model to assess mortality risk in patients with 3VD.
Methods:
This study wa...
Few studies have characterized long-term exposure to lipoprotein(a), or Lp(a), different glucose metabolism status, and their joint role in adverse cardiovascular outcomes risk. We consecutively enrolled 10,724 coronary heart disease (CAD) patients from January to December 2013 in Fuwai Hospital. Associations of cumulative lipoprotein(a) (CumLp(a))...
Background:
It is well established that lipoprotein(a)[Lp(a)] and low-density lipoprotein cholesterol (LDL-C) play a vital role in atherosclerosis. We investigated the prevalence and prognostic implications of increased Lp(a) in patients undergoing percutaneous coronary intervention (PCI) according to different LDL-C concentrations.
Methods:
A t...
Background
Total occlusion is the most severe coronary lesion, indicating heavy ischemic burden and poor prognosis. The lipid profile is central to the development of atherosclerotic coronary lesions. Evidence on the optimal lipid measure to be monitored and managed in patients with established coronary artery disease (CAD) is inconclusive.
Method...
Introduction: The accurate assessment of individual risk can be of great value to facilitate the prevention of recurrent coronary thrombosis events (CTEs) in patients after percutaneous coronary intervention (PCI) with Drug-Eluting Stents (DES). However, current prediction models in common use were often formulated in white populations and were of...
Background and aims
In patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI), the effects of high-sensitivity C-reactive protein (hsCRP) on Lipoprotein(a) (Lp(a))-associated cardiovascular risk remains unclear. This study aimed to investigate the independent and combined association of Lp(a) and hsCRP with...
- [...]
Background and aims
The present study aimed to examine the association between big endothelin-1 (big ET-1) and long-term all-cause death in patients with coronary artery disease (CAD) and different glucose metabolism status.
Methods and results
We consecutively enrolled 8550 patients from January 2013 to December 2013. Patients were categorized ac...
Background:
Coronary heart disease and diabetes are highly interrelated and complex diseases. We proposed to investigate the association of genetic polymorphisms of the lipoprotein important regulatory genes Niemann-Pick C1-like 1 (NPC1L1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients with premature triple-vessel coronary...
Background: Patients with diabetes mellitus (DM) are considered to increase the risk of thrombosis and bleeding. However, whether DM is an independent risk factor for events in patients anticoagulated with bivalirudin during elective percutaneous coronary intervention (PCI) is not clear. Methods: Patients anticoagulated with bivalirudin during elec...
AimsTo explore the effects of age and sex on the outcomes of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients with the three-vessel disease (TVD).Methods and ResultsThe study is a subanalysis of data from a prospective cohort of 8,943 patients...
Background
Inflammation plays a crucial role in coronary atherosclerosis progression, and growing evidence has demonstrated that the fibrinogen-to-albumin ratio (FAR), as a novel inflammation biomarker, is associated with the severity of coronary artery disease (CAD). However, the long-term risk of cardiovascular events remains indistinct in patien...
Background
Circulating cell-free DNA (cfDNA) can be released when myocardial damage occurs.
Methods
Here, we used the methylated CpG tandem amplification and sequencing (MCTA-seq) method for analyzing dynamic changes in heart-derived DNA in plasma samples from myocardial infarction (MI) patients.
Results
We identified six CGCGCGG loci showing hea...
Background:
Evidence on factors associated with guideline-directed secondary prevention medication (GDPM) after percutaneous coronary intervention (PCI) and its effect on the prognosis of patients with coronary artery disease (CAD) is lacking in China.
Aims:
To ascertain predictors of GDPM in real-world clinical practice and to assess the effect...
Background: Both Niemann-Pick C1-like 1 (NPC1L1) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) play a key role on dyslipidaemia. We aim to evaluate whether NPC1L1 and HMGCR genetic variants are associated with susceptibility of premature triple-vessel disease (PTVD).
Methods: Four single-nucleotide polymorphisms (SNPs) (rs11763759, rs...
Introduction: A lot of large studies (HORIZONS-AMI, BRIGHT, EUROMAX, etc.) have shown that bivalirudin in acute myocardial infarction patients undergoing primary percutaneous coronary intervention (PCI) could reduce the bleeding while prevent thrombosis. However, data on patients undergoing elective PCI are lacking which warrants research attention...
Introduction: Patients with Diabetes Mellitus (DM) and coronary heart disease have high risk in bleeding and thrombotic events. However, data on safety and effectiveness of bivalirudin in patients with DM undergoing elective percutaneous coronary intervention (PCI) are lacking which needs further scientific research.
Methods: 1152 patients undergoi...
Background: Platelet reactivity is closely associated with adverse events in percutaneous coronary intervention (PCI) patients. Inflammation plays a crucial role in the development of coronary heart disease (CHD).
Aim: To investigate the association of inflammatory biomarkers such as leukocyte count and high-sensitivity C reactive proteins (hs-CRP)...
Aims
The PRECISE-DAPT score is recommended by guidelines for predicting out-of-hospital bleeding in patients after percutaneous coronary intervention (PCI). However, the long-term prognostic value of the PRECISE-DAPT score in patients after PCI remains unclear.
Methods and Results
We performed a prospective study of 10,724 patients who underwent P...
Background: Despite substantial improvement in chronic total occlusions (CTO) revascularization technique, the long-term clinical outcomes in diabetic patients with revascularized CTO remain controversial. Our study aimed to investigate the 5-year cardiovascular survival for patients with or without type 2 diabetes mellitus (DM) who underwent succe...
Background
Fibrinogen (FIB) is an independent risk factor for mortality and cardiovascular events in the general population. However, the relationship between FIB and long-term mortality among CAD patients undergoing PCI remains unclear, especially in individuals complicated with diabetes mellitus (DM) or prediabetes (Pre-DM).
Methods
6,140 patien...
Background
In euthyroid patients undergoing percutaneous coronary intervention (PCI), it is still unclear whether free triiodothyronine to free thyroxine (FT3/FT4) ratio can predict the recurrence of cardiovascular events (CVEs). We aim to investigate its association with recurrent long-term adverse events in this population.
Methods
3549 euthyroi...
Abstract Background Oral antiplatelet therapy is the cornerstone of treatment for acute myocardial infaction (AMI). However, detailed usage data on oral antiplatelet therapy are lacking. Methods Using data from a nationally representative sample of patients with AMI, the detailed usage of oral antiplatelet therapy was analyzed in 40,202 consecutive...
The prognostic value of high-sensitivity C-reactive protein (hsCRP) in complex coronary artery disease has not been fully established. We aimed to determine the association between hsCRP and long-term outcomes in elderly patients with 3-vessel disease (TVD). From April 2004 to February 2011, 3069 patients aged ≥65 years with TVD were consecutively...
Background: Fibrinogen (FIB) is an independent risk factor for mortality and cardiovascular events in the general population. However, the relationship between FIB and long-term mortality among CAD patients undergoing PCI remains unclear, especially in individuals complicated with diabetes mellitus (DM) or prediabetes (Pre-DM).
Methods: 6,140 patie...
Background: Despite substantial improvement in chronic total occlusions (CTO) revascularization technique, the long-term clinical outcomes in diabetic patients with revascularized CTO remain controversial. Our study aimed to investigate the five-year cardiovascular survival for patients with or without type 2 diabetes mellitus (DM) who underwent su...
Background
Patients with diabetes and triple-vessel disease (TVD) are associated with a high risk of events. The choice of treatment strategies remains a subject of discussion. In the real-world, we aim to compare the outcomes of medical therapy (MT), coronary artery bypass grafting (CABG), and percutaneous coronary intervention (PCI) treatment str...
Background:The optimal percutaneous coronary intervention (PCI) strategy for multivessel lesions in the setting of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) remains controversial. This study sought to compare long-term prognosis between single-vessel PCI (SV-PCI) and multivessel PCI (MV-PCI) in patients with multivessel coronary a...
Background:Moderate/severe coronary artery calcification (CAC) predicts worse clinical outcomes in patients undergoing percutaneous coronary intervention (PCI). However, to date most studies have been modest in size and with limited follow-up. We aimed to assess the association between calcification severity and long-term clinical outcomes in a lar...
Aims Three-vessel disease (TVD) is a severe coronary heart disease (CHD) with poor prognosis. Niemann-Pick C1-like 1(NPC1L1) is a transporter protein for exogenous cholesterol absorption, and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is a rate-limiting enzyme for cholesterol synthesis. We aimed to investigate the association between N...
Background and Aims
It is still controversial whether obesity and overweight increase the risk of mortality for patients with coronary artery disease. The current study aimed to investigate the relationship between body mass index (BMI) and mortality in patients with triple-vessel disease (TVD).
Methods and Results
From April 2004 to February 2011...
Background:The aim of this study is to compare the long-term prognosis of non-ST elevation acute coronary syndrome (NSTE-ACS) patients with 3-vessel disease (3VD) who underwent percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) or medical therapy (MT).
Methods and Results:Overall, 3,928 NSTE-ACS patients with 3VD were...
Objective. We aim to evaluate the long-term prognosis of non-ST elevation acute coronary syndrome (NSTE-ACS) patients with high-risk coronary anatomy (HRCA). Background. Coronary disease severity is important for therapeutic decision-making and prognostication among patients presenting with NSTE-ACS. However, long-term outcome in patients undergoin...
Background:
Data of susceptible gene polymorphisms related to progression of coronary atherosclerosis in patients with three-vessel disease (TVD) is limited in China. This case-control study aimed to analyze the differences of variant carrier frequencies between cases and controls, and to explain the possible genetic effects on the progression of...
Background
D-dimer has predictive value for mortality in some diseases. This study aimed to evaluate the correlation between D-dimer and mortality in patients undergoing percutaneous coronary intervention (PCI).
Methods
We examined 10,724 consecutive patients who underwent PCI between January 2013 and December 2013. The primary endpoint was all-ca...
Objectives:
To assess the predictive value of the Global Registry of Acute Coronary Events (GRACE) discharge score for patients with stable coronary artery disease (SCAD) after percutaneous coronary intervention (PCI).
Background:
The GRACE score is widely used for predicting the mortality of acute coronary syndrome patients. However, the predic...
Objective:
This study sought to assess whether the predilation, scaffold/stent sizing, and postdilation (PSP) score for bioresorbable scaffold (BRS) implantation was associated with outcomes following metallic drug-eluting stent (DES) implantation.
Background:
The PSP score is associated with patients' prognoses after BRS implantation.
Methods:...
Background and aim:
To explore the prevalence of unknown diabetes (DM) or prediabetes (pre-DM) in "nondiabetic" patients and its association with 2-year clinical outcomes after primary percutaneous coronary intervention (PCI).
Methods and results:
5202 consecutive "nondiabetic" patients who underwent primary PCI at Fuwai Hospital from January to...
The aim of the cohort study was to investigate the relation between plasma lipoprotein(a) (Lp[a]) and long-term clinical outcomes in patients with three-vessel disease (TVD) after the following treatment strategies, including medical therapy alone, percutaneous coronary intervention, and coronary artery bypass grafting. A total of 6,175 consecutive...
Aims:
Risk assessment and treatment stratification for three-vessel disease (3VD) remain challenging. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an established biomarker for prognostication and treatment in heart failure. The present study aimed to evaluate the prognostic value of NT-proBNP beyond the SYNTAX score II (SSII), and its...
The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) thrombotic risk score is a novel score for predicting the risk of coronary thrombotic events after percutaneous coronary intervention (PCI). We assessed the prognostic value of this score for mortality in patients with PCI. In this prospective, observational study, w...
Aim: To evaluate the prognostic value of plasma big endothelin-1 level in the context of three-vessel disease (TVD) with heavy atherosclerotic burden.
Methods: A total of 6,150 patients with TVD and available big endothelin-1 data were included in the study. Participants were divided into two groups according to the optimal cutoff value of big endo...
Background:
With the advancements of percutaneous coronary interventions (PCI), it is not clear whether unprotected left main (ULM) coronary artery disease (CAD) remains an independent predictor of adverse outcomes after PCI therapy. We have therefore carried out a large cohort study to investigate the impact of ULM disease on 2-year clinical outc...
Aims:
The predictive value of white blood cells in triple-vessel coronary artery disease (TVD) remains unclear. This study aimed to examine the relationship between WBC counts and long-term prognosis of TVD.
Methods:
A total of 8943 consecutive patients with triple-vessel coronary artery disease were enrolled from April 2004 to February 2011. Th...
Objective
To explore the relationship between inhospital outcomes and different estimated glomerular filtration rates (eGFRs) and determine an optimal eGFR cutoff value for predicting risk in patients with renal insufficiency (RI).
Background
RI is a predictor of poor prognosis in patients with myocardial infarction undergoing primary percutaneous...
Hyperuricemia has been associated with mortality in patients with coronary artery disease (CAD). However, its prognostic value remains unknown in the context of severe CAD with heavy atherosclerotic burden in all 3 vessels. We used data from a large cohort of consecutive patients with severe CAD. The primary end point was all-cause death. Propensit...
This study investigated the association of thrombocytopenia (TP) with in-hospital medication and outcome of patients with acute ST-segment elevated myocardial infarction (STEMI). A total of 16,678 consecutive patients with STEMI from multiple centers that participated in the China Acute Myocardial Infarction registry was included. In-hospital adver...
Objectives:
We sought to evaluate the independent predictive value of left main disease (LMD) and/or three-vessel disease (LMD/3VD) in acute myocardial infarction (AMI) patients.
Background:
Patients with acute coronary syndrome resulting from LMD and/or three-vessel disease (LMD/3VD) are at the highest risk of adverse cardiovascular events. Neu...
We developed a new risk factor profile for contrast-induced acute kidney injury (CI-AKI) under a new definition in patients who underwent an emergency percutaneous coronary intervention (PCI). Consecutive patients (n = 1061) who underwent an emergency PCI were divided into a derivation group (n = 761) and a validation group (n = 300). The rates of...
Aim:
To investigate the impact of diabetic status on 2-year clinical outcomes in Chinese patients undergoing contemporary percutaneous coronary intervention (PCI) treatment.
Methods and results:
A total of 10 724 consecutive patients underwent PCI at Fu Wai Hospital were prospectively collected. Two-year clinical outcomes were compared between p...
Objective:
This study aimed to assess the prognostic ability of synergy between percutaneous coronary intervention with Taxus and cardiac surgery score II (SS-II) in a large cohort of patients with complex coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) in clinical practice.
Background:
Few studies have explored...
Aims:
This study assessed the prognostic capacity of residual SYNTAX score (rSS) in a large cohort of patients undergoing percutaneous coronary intervention(PCI) in clinical practice.
Methods and results:
10,344 consecutive patients were prospectively enrolled. Complete revascularization (CR; rSS=0), reasonable incomplete revascularization (RICR...
Citations
... While prior research primarily focused on SHR's predictive capacity for adverse outcomes in sepsis 8 and coronary artery disease 9 , recent studies have expanded its value to predicting stroke recurrence, onset, and mortality in AIS patients 10 . Despite these advances, the reliability of SHR in critically ill AIS patients, who often suffer complex pathophysiological pro les, remains uncertain. ...
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... A large-scale research from Danish population with 2973 participants showed that a lower RC of 0.8 mmol/L could reduce the incidence of recurrent major cardiovascular event by 20% for patients with myocardial infarction or cerebral infarction [12]. A recent clinical study revealed that inflammatory biomarkers, such as high-sensitivity C-reactive protein and systemic immune-inflammation index, were independently associated with RC levels [13]. Experimental studies showed that RC may enhance the systematic inflammation and neuroinflammation [14,15], oxidative stress [16], platelet activation and coagulation abnormalities [17,18]. ...
... These results suggest that serum FFA levels could help identify patients with ARDS undergoing off-pump CABG. Previous research has highlighted the association between elevated FFAs and cardiovascular risk in patients with CAD, as well as the elevation of serum FFAs following on-pump CABG, which has been linked to pulmonary hypoxemia [19,20]. Inconsistent with these findings, we demonstrated that decreased FFA correlates with worse outcomes in offpump CABG patients. ...
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... A large 2 × 2 factorial mendelian randomization study [10] showed that variants of NPC1L1 and HMGCR genes were related to higher risk of CHD. Moreover, our previous studies [11][12][13] demonstrated that single nucleotide polymorphisms (SNPs) of NPC1L1 and HMGCR genes were associated with residual cholesterol risk, PTVD susceptibility, and major adverse cardiac and cerebrovascular events (MACCE) in TVD patients. However, genetic studies on the association of HMGCR and NPC1L1 gene polymorphisms with CAC susceptibility has never been reported before. ...
... Large cohort studies have provided mixed results on the association between Lp(a), Hs-CRP, with cardiovascular risk, suggesting variability by race, sex, and specific cardiovascular outcomes (37)(38)(39)(40)(41). Notably, in certain populations, elevated Lp(a) levels combined with high Hs-CRP significantly correlate with increased risks of major adverse cardiovascular events (MACE), heart failure rehospitalization, and cardiovascular death, while in other populations, such associations have not been observed (38)(39)(40)(41). Furthermore, adding other biomarkers like residual cholesterol or D-dimer to the Lp(a) and Hs-CRP combination has shown that the highest levels of these markers correlate with the greatest risk of adverse outcomes in CHD patients (42,43). Yet, the predictive value of combining Lp(a) and Hs-CRP for death risk in AMI patients remains uncertain. ...
... The most common independent demographic predictors of increased risk of MACE/MACCE were higher age [15, 16, 22, 27, 28, 31-33, 36, 40, 42, 45] and male sex [25,37]. The main comorbidities which predicted escalated MACE/MACCE risk were as follows: history of myocardial infarction (MI) before the studied exposure [15,17,24,28,33,42,45], CABG [20], Stroke [23], cardiovascular disease [42], diabetes (DM) [17,26,28,30,37,39,43,44], hypertension (HTN) [20,26,45,47], and chronic kidney disease (CKD) [29]. One study presented that patients with a positive CAD family history had a higher risk of adverse events [37]. ...
... As a downstream protein in the activated inflammatory pathway that mediates the progression of atherosclerosis, high-sensitivity C-reactive protein (hs-CRP) is considered to be a biomarker of inflammatory state and a major predictor of MACE in cardiovascular disease [90][91][92]. Through a study of 10,724 patients undergoing PCI, Guyu Zeng's team found that patients with elevated hsCRP had the highest risk of MACE, which confirmed the prognostic value of hs-CRP in secondary prevention after PCI, and also indicated that inflammation plays a key role in the recurrence of cardiovascular events [93]. A large sample clinical study of 4263 patients with PCI was followed up for 1 month and found that the hs-CRP level of patients treated with PCI was significantly higher than that of patients without PCI [94]. ...
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... Therefore, in a population with high ischemic risk, shorter-duration TAT might be promising in improving net clinical outcomes. Based on the results from ATLAS ACS2-TIMI51 trial(2), the ATLAS ACS-TIMI46 trial(3) and analysis from our own cohort of Chinese PCI patients (22), we have limited candidates for TAT to high-thrombotic-risk ACS patients, and shortened TAT duration to 3 months in PRIDE-ACS trial. ...
... Some studies also found that CRP-albumin ratio (CAR) may be an important indicator for predicting cardiovascular risk. [5][6][7][8][9] Our previous studies 10,11 also confirmed that the combined indicator of CRP and albumin played a similar role in evaluating the prognosis of patients with acute myocardial infarction as the Global Registry of Acute Coronary Events (GRACE) score. In addition, platelet-lymphocyte ratio (PLR) was also found to have good predictive value for cardiovascular events. ...
... Despite these challenges, emerging evidence suggests a significant association between elevated plasma Lp(a) levels and the incidence of atherosclerotic cardiovascular diseases in DM patients, particularly in T2DM. The theoretical underpinnings of Lp(a)'s increased glycated state and abundance of oxidized phospholipids support its role in promoting atherogenesis [25]. Notably, impaired endothelial function in T2DM patients could further amplify the atherogenic potential of Lp(a) in this population.Studies investigating the role of Lp(a) as an independent predictor of cardiovascular disease (CVD) in DM patients, particularly T1DM, provide compelling evidence of its contribution to coronary artery disease (CAD) risk [26,27]. ...
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