Xu Zhu's research while affiliated with First Affiliated Hospital of China Medical University and other places
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Publications (3)
Background
This study was designed to explore the mechanisms through which chondrocytes regulated endothelial cell migration and angiogenesis in Osteoarthritis (OA).
Methods
The expressions of related genes of OA were detected by Western blot and real-time quantitative PCR. Chondrocytes were co-cultured with endothelial cells, and migration as wel...
Osteoarthritis (OA), which is characterized by articular cartilage degeneration, shows a gradually increasing incidence with age. This study explored the molecular mechanism underlying the proliferation and apoptosis of chondrocytes during OA progression. In this study, chondrocytes were isolated from human knee cartilages. The targeted relationshi...
Background:
Osteoarthritis (OA) is an aging-related chronic degenerative joint disease. A number of miRNAs have been found to be involved in the development of OA, but the role of miR-613 in OA remains unclear. Thus, this study aimed to investigate the role of miR-613 during the progression of OA.
Methods:
CHON-001 cells were transfected with mi...
Citations
... Therefore, inhibiting VECs during CTE is of great significance in promoting the formation of high-quality hyaluronic cartilage during cartilage injury repair. After a cartilage injury, the local VECs can be activated by local inflammation, hypoxia, and other factors [11][12][13]. The phenotype and function of activated VECs change, with the up-regulation of E-selectin, one of the adhesion molecules, and enhanced ability to recruit inflammatory macrophages [13]. ...
... Xu et al. revealed that danshensu inhibits IL-1β-induced inflammatory response in chondrocytes and OA, possibly via suppression of the nuclear factor-κB (NF-κB) signaling pathway [3]. Moreover, Xiao et al. suggested that microRNA-613 alleviates IL-1β-induced injury in chondrogenic CHON-001 cells by targeting fibronectin 1 [4]. Furthermore, Jia et al. demonstrated that garcinol suppresses IL-1β-induced chondrocyte inflammation and OA via inhibition of the NF-κB signaling pathway [5]. ...
... and Neat1 in a mouse model of chronic HA. 8 The function of similar lncRNAs in other joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA), in terms of disease onset and advancement, has been extensively studied. [9][10][11][12][13] The dysregulation of lncRNAs, including Neat1, H19, Mir22hg and Malat1, in collagen-induced arthritis (CIA), OA and RA patients or in animal models, has also been reported. 12,[14][15][16] Neat1 (nuclear enriched abundant transcript 1) lncRNA has a crucial role in maintaining the integrity of the nuclear paraspeckle substructure. ...
