Xiujie Zhu's research while affiliated with Jilin University and other places
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Publications (8)
3D-printed Porous Titanium Alloy Implants (pTi), owing to their biologically inertness and relatively smooth surface morphology, adversely affect the biological functions of surrounding cells. To address the challenges, constructing a bioinspired interface that mimics the hierarchical structure of bone tissue can enhance the cellular functions of c...
The absence of a conducive bone formation microenvironment between fractured ends poses a significant challenge in repairing large bone defects. A promising solution is to construct a bone formation microenvironment that mimics natural bone tissue. Biomimetic mineralized collagen possesses a chemical composition and microstructure highly similar to...
The growth plate is a cartilaginous tissue with three distinct zones. Resident chondrocytes are highly organized in a columnar structure, which is critical for the longitudinal growth of immature long bones. Once injured, the growth plate may potentially be replaced by bony bar formation and, consequently, cause limb abnormalities in children. It i...
Bisphosphonates (BPs), the stable analogs of pyrophosphate, are well-known inhibitors of osteoclastogenesis to prevent osteoporotic bone loss and improve implant osseointegration in patients suffering from osteoporosis. Compared to systemic administration, BPs-incorporated coatings enable the direct delivery of BPs to the local area, which will pre...
Mineralized collagen (MC) is the basic unit of bone structure and function and is the main component of the extracellular matrix (ECM) in bone tissue. In the biomimetic method, MC with different nanostructures of neo-bone have been constructed. Among these, extra-fibrous MC has been approved by regulatory agencies and applied in clinical practice t...
Although there have been remarkable advances in cartilage tissue engineering, construction of irregularly shaped cartilage, including auricular, nasal, tracheal, and meniscus cartilages, remains challenging because of the difficulty in reproducing its precise structure and specific function. Among the advanced fabrication methods, three-dimensional...
Citations
... Many advanced 3D printing techniques, with fast printing speed and high precision have been developed in the past several decades, including fused deposition modeling (FDM) [14][15][16], continuous liquid interface production (CLIP) [17,18], high-area rapid printing (HARP) [19], rapid continuous stereolithography based on volumetric polymerization inhibition patterning [20], dualcolor xolography volumetric 3D printing [21,22], volume 3D printing based on tomographic reconstruction [23][24][25][26], etc. The development of 3D printing technology has provided numerous advantages for manufacturing prototypes of tubular structures such as tubular grafts and biomimetic blood vessels [1,[27][28][29][30]. For example, van Lith et al used CLIP to achieve high-precision tubular graft of 2 cm long printing in less than 20 min [31]. ...
... Therefore, the introduction of bone graft substitutes has been used to enhance bone healing and strengthen fragile bone [15]. Recently, an artificial biomimetic mineralized collagen (MC) bone repair material has been developed, which mimics the nanoscale fundamental unit of the natural bone [16,17]. Its microstructure accounts for its active osteo-induction and good osteogenic activity. ...
... Such heterogeneity has been applied in osteochondral tissue engineering to mimic gradient microstructure to induce osteochondral regeneration [11]. The external ear has been distinguished by its intricate morphology and varied biomechanical properties across the auricular cartilage [12][13][14][15]. The composition and arrangement of the ECM have been found to vary in different regions of auricular cartilage and evolve with age [16][17][18][19]. ...