Xintian Lan's research while affiliated with China Academy of Traditional Chinese Medicine and other places
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Publications (8)
(1) Background: Solanum nigrum L. is a plant of the genus Solanum in the family Solanaceae and is commonly used to treat tumors. Solasonin (SS) is a steroidal alkaloid extracted from Solanum nigrum L. that has anti-colorectal cancer (CRC) activity. (2) Methods: Column chromatography, semi-preparative HPLC and cellular activity screening were used t...
Alzheimer’s disease (AD) is a prevalent degenerative condition that is increasingly affecting populations globally. American ginseng (AG) has anti-AD bioactivity, and ginsenosides, as the main active components of AG, have shown strong anti-AD effects in both in vitro and in vivo studies. It has been reported that ginsenosides can inhibit amyloid β...
Nonalcoholic fatty liver disease (NAFLD) is a common condition that is prevalent in patients who consume little or no alcohol, and is characterized by excessive fat accumulation in the liver. The disease is becoming increasingly common with the rapid economic development of countries. Long-term accumulation of excess fat can lead to NAFLD, which re...
Nephropathy is a general term for kidney diseases, which refers to changes in the structure and function of the kidney caused by various factors, resulting in pathological damage to the kidney, abnormal blood or urine components, and other diseases. The main manifestations of kidney disease include hematuria, albuminuria, edema, hypertension, anemi...
Breast cancer (BC) is one of the most common malignant tumor, the incidence of which has increased worldwide in recent years. Ginsenosides are the main active components of Panax ginseng C. A. Mey., in vitro and in vivo studies have confirmed that ginsenosides have significant anti-cancer activity, including BC. It is reported that ginsenosides can...
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MicroRNAs are small non-coding RNAs that play important roles in gene regulation by influencing the translation and longevity of various target mRNAs and the expression of various target genes as well as by modifying histones and DNA methylation of promoter sites. Consequently, when dysregulated, microRNAs are involved in the development and progre...
Citations
... Currently, China is the largest consumer of American ginseng and the third-largest producer worldwide [2]. Ginsenosides are the most well-known active ingredients of American ginseng and have various pharmacological activities, namely, improving immunity, preventing certain tumours, exerting anti-inflammatory effects, and delaying aging [3][4][5]. ...
... These considerations make tackling NAFLD a formidable challenge, and the interventions and chemicals employed for clinical trials are also with little success. Encouragingly, armed with the advantage of high efficacy and low toxicity, natural products have increasingly gained attention as potential therapeutic agents for the treatment of NAFLD [5]. Natural products have served as a vast platform for the development of safe and cost-effective drugs or supplements. ...
... Ginsenosides are active ingredients extracted from ginseng and are widely used in traditional herbal medicine Fan et al., 2023). Studies have shown that ginsenosides possess various pharmacological effects, including blood pressure regulatory. ...
... Additionally, it can reduce senescence markers and ROS accumulation [164]. Regardless of its components and their epigenetic modulatory abilities, Asparagus cochinchinensis-derived smilagenin has been demonstrated to be involved in HAT enhancement [165] while ginsenosides of ginseng inhibited the expression of miR18 in breast cancer cells, thus preventing the metastatization process (ginsenoside Rd), and miR4425 and miR3614-3p, thus limiting BC cells proliferation by stimulating their apoptosis (ginsenoside Rh2) [166]. ...
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... Salvia miltiorrhiza is extensively used as an herbal remedy in traditional Chinese icine. The plant belongs to the Lamiaceae family, and its medicinal components in the roots or rhizomes [18]. The chemical compounds extracted from Salvia miltiorrhiz be classified into two main groups: (i) fat-soluble tanshinone compounds, predomin Tanshinone I and Tanshinone IIA, and (ii) water-soluble phenolic compounds, prim including salvianolate [19]. ...
