Xingyu Mu's research while affiliated with First Affiliated Hospital of China Medical University and other places
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Publications (10)
Objectives
The objective of this study was to develop a predictive nomogram for intermediate-risk differentiated thyroid cancer (DTC) patients after fixed 3.7GBq (100mCi) radioiodine remnant ablation (RRA).
Methods
Data from 265 patients who underwent total thyroidectomy with central lymph node dissection (CND) and received RRA treatment at a sing...
A 16-year-old woman presented with an acute headache on the left side. A head CT scan revealed bone destruction in the skull. Subsequent ¹⁸ F-FDG and ¹⁸ F-FAPI PET/CT scans were performed within a week. The ¹⁸ F-FDG PET/CT indicated mild uptake in the regions of bone destruction, whereas the ¹⁸ F-FAPI PET/CT displayed significant tracer accumulatio...
![Maximum-intensity-projection images of [¹⁸F]FAPI-42 PET/CT at early and...](publication/376407878/figure/fig2/AS:11431281211163759@1702314027071/Maximum-intensity-projection-images-of-FFAPI-42-PET-CT-at-early-and-late-timepoint-in_Q320.jpg)
![Comparison of visual score between early and late [¹⁸F]FAPI-42 PET in...](publication/376407878/figure/fig4/AS:11431281211171926@1702314027704/Comparison-of-visual-score-between-early-and-late-FFAPI-42-PET-in-primary-lesions-LN_Q320.jpg)
![Comparison of uptake on [¹⁸F]FAPI-42 PET between early and late...](publication/376407878/figure/fig5/AS:11431281211171927@1702314027909/Comparison-of-uptake-on-FFAPI-42-PET-between-early-and-late-FFAPI-42-PET-SUVmax_Q320.jpg)
Purpose
This study aimed to assess the biodistribution, detection rate, and uptake of the [¹⁸F]FAPI-42 at two distinct time intervals.
Methods
This prospective study enrolled 60 consecutive patients (median age 59; range 35–74) referred to [¹⁸F]FAPI-42 PET/CT. [¹⁸F]FAPI-42 PET/CT was performed early and late timepoint after tracer injection for st...
Prostate-specific membrane antigen (PSMA) PET/CT has become increasingly accepted for imaging prostate cancer (PCa), including its recent use in primary staging. In this case report, we present the case of a 76-year-old man with newly diagnosed PCa. ¹⁸ F-PSMA-1007 PET/CT showed minimal PSMA activity in the primary tumor and metastases. However, ¹⁸...
Objective
To explore the additional functionalities of ¹⁸F-sodium fluoride-positron emission tomography/computed tomography (¹⁸F-NaF PET/CT) for evaluation and prediction of bone mineral density (BMD) levels in differentiated thyroid cancer (DTC) under thyrotropin suppression.
Methods
This study analyzed retrospectively 231 DTC patients who was re...
Background
This study was to compare the diagnostic performance, semiquantitative analysis, and staging performance of [¹⁸F]-labelled fibroblast activation protein inhibitor ([¹⁸F]FAPI-42) and 2-[¹⁸F]fluoro-2-deoxy-D-glucose(2-[¹⁸F]FDG) PET/CT in lymph node (LN) metastases.
Methods
From the detection of metastatic LNs, the semiquantitative value o...
Purpose
This study aimed to assess the diagnostic performance of [¹⁸F]FAPI-42 PET/CT and compare it with that of 2-[¹⁸F]FDG PET/CT in patients with differentiated thyroid cancer (DTC) with biochemical elevations in Tg or anti-Tg antibodies.
Methods
A total of 42 patients with DTC with biochemical elevations in Tg or anti-Tg antibodies underwent [¹...
Vertebral brucellosis is a relatively rare disease that usually emerges in animal husbandry areas. We report a case that brucellosis of lumbar vertebral body showed an intense uptake of FAPI on 18F-FAPI PET/CT, which mimics to malignant lesions or vertebral tuberculosis. It is an interesting finding to realize that vertebral brucellosis is also one...
Purpose
To calculate the physiological uptake of various tissues in patients with cancer using ¹⁸ F-AlF-NOTA-FAPI-04 ( ¹⁸ F-FAPI-04) and ¹⁸ F-AlF-NOTA-FAPI-42 ( ¹⁸ F-FAPI-42) PET/CT and to compare the variation in standard uptake values between the two scans.
Materials and methods
This retrospective analysis included 40 patients with cancer who un...
Purpose
This study aimed to assess the diagnostic performance of [¹⁸F]FAPI-42 PET/CT and compare it with that of 2-[¹⁸F]FDG PET/CT in patients with differentiated thyroid cancer (DTC) with biochemical incomplete response.
Methods
A total of 42 patients with DTC with biochemical incomplete response underwent [¹⁸F]FAPI-42 PET/CT as part of this stud...
Citations
... SEMA3A has also been proposed as both a major mediator of nerve regulation in bone turnover as well as a factor in osteoblast-osteoclast coupling [46,47]. Lastly, MMP-2 and FAP-α are proteases involved in remodeling fibrotic tissue whose mRNA levels were significantly upregulated in previous studies and may be useful as biomarkers for FD [11,17,20,[48][49][50]. Moreover, these pathways in have been investigated as potential therapeutic targets in a broad range of disorders as fibrosis is a common feature underpinning many disease processes including heart failure [51], cancer [52], diabetes [53], and others [54,55]. ...
... Fibroblast activating protein (FAP) is overexpressed by cancer-associated fibroblasts of several tumors. Some authors have shown that PET/CT, with a relatively recent tracer that detects the expression of FAP inhibitor (FAPI), in DTC patients with increased Tg or anti-Tg antibodies has diagnostic performance comparable to that of [ 18 F]FDG PET/CT, in fact, can be used in patients with inconclusive results [ 18 F]FDG PET/CT [46,47]. In some advanced DTC RAI-R cases who have had disease progression despite undergoing standard treatment regimens, radiopharmaceuticals that enable radioreceptor therapy, such as SSA-tracers and newer radiopharmaceuticals, prostate-specific membrane antigen (PSMA), and FAP-targeting tracers, could be considered [48]. ...
... As PET evolves, 18 F-FDG is slowly becoming supplanted by amino-acid imaging (when available), with radioligands such as 11 C-MET, 18 F-FET, and 18 F-DOPA (9). Along with the crucial advantage that amino acid tracers can easily permeate across the BBB (whether the BBB is compromised or not), this pathway is thus more specific in highlighting "live" proliferating cells rather than structural changes. ...
