Xin-Hui Qu's research while affiliated with First Affiliated Hospital of China Medical University and other places

... Other findings indicate that metformin may increase mitochondria efficiency and reduce oxidative damage; in particular, metformin inhibits mitochondrial dysfunction and apoptosis induced by high glucose in cardiomyocytes through upregulation of AMPK activity [118]. Moreover, metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion (reversing the alteration in Mfn2 and OPA1 levels) [119]. ...

... A sharp increase in green fluorescence of JC-1 monomer and decrease in red fluorescence of JC-1 aggregate were detected in 4T1 cells treated with PYT NPs + NIR (Fig. 5a), suggesting a decrease of MMP level and damage in mitochondrial function. In order to observe the morphological changes of mitochondria, 4T1 cells were transfected with mito-DsRed2 plasmid [58,59]. As shown in Fig. 5b, mitochondria in 4T1 cells treated with PBS, NIR or PYT NPs display as the thread-like or tubular structures under laser confocal microscope. ...

... The flavonoid significantly increased the sensitivity of resistant cells to tamoxifen by inhibiting cell proliferation and inducing apoptosis via the inhibition of HIF-1α, a protein that promotes cancer growth. In Hua et al.'s [34] study, baicalein sensitizes a subtype of the refractory breast cancers with resistance to chemotherapy and poor prognosis to doxorubicin via the autophagy-mediated down-regulation of CDK1. Zeng et al. [35] found that baicalin sensitized breast cancer cells to docetaxel by suppressing the expression of survivin/Bcl-2. ...

... These morphological changes are not merely a consequence of liver injury but actively contribute to the progression of ALD. Mitochondria are also involved in the regulation of apoptosis, and alcohol-induced mitochondrial dysfunction can trigger apoptotic pathways in hepatocytes [23,24]. This process is mediated through the release of pro-apoptotic factors like cytochrome c, further contributing to liver injury. ...

... 28 Metformin can promote CDDP resistance through Parkinmediated mitophagy in gastric cancer. 29 A recent study also showed that mitophagy functions to attenuate CDDP-induced ferroptosis in renal tubular epithelial cells. 30 Besides, impairing mitophagy aggravates CDDP-induced ototoxicity, nephrotoxicity, and neurotoxicity. ...

... According to the fndings, the binding of chrysophanol-8-0-glucoside (pulmatin) to the MAPK3 catalytic domain Chrysophanol, an anthraquinone metabolite obtained from the Rheum genus, has been found to possess anticancer properties in recent studies [51][52][53]. In addition, it exhibits anti-infammatory activity [54] and provides neuroprotection efects [55]. ...

... A study on mTORC2 suppression and its impact on MFN2 supports MFN2 downregulation is responsible for cancer progression in breast cancer [25]. Conversely, in ovarian cells, the downregulation of MFN2 sensitizes resistant cells to cisplatin [26]. Further studies are required to understand the exact role of MFN2 in radiationresistant SiHa cells. ...

... [4][5][6]8,9 Moreover, common causes of corneal insults, such as UV light exposure, oxidative stress, chemical injury, and epithelial debridement, compromise mitochondrial integrity, dynamics, and function. 4,6,37,38 Interestingly, restoration of corneal mitochondrial respiration has been linked to corneal wound healing. 4 In light of these findings, mitochondria-targeted therapies emerge as an attractive strategy for supporting wound healing. ...

... Aβ1-42induced caspase-3 cleavage and neuronal apoptosis were prevented after blocking CDK5-induced phosphorylation of Drp1 Ser579 by a phosphorylation-defective (phosphorylation-deficient) mutant lentiviral vector (Lenti-Drp1-S579A) [235]. Therefore, we learned that blocking Drp1 Ser579 phosphorylation inhibits Aβ1-42-induced neurological damage [236]. Tau accumulation modification in Alzheimer's disease triggers mitochondrial damage has been demonstrated in a novel cryptic nematode model of H. cepacian [237]. ...

... Similarly, the rapid identification of pathogens using modern diagnostic tools, such as the FilmArray Meningitis/Encephalitis panel, has been shown to significantly improve the differentiation between bacterial and viral meningitis 10 . Furthermore, studies by Hristea et al. (2012) and Yang et al. (2020) have developed clinical prediction rules and diagnostic formulas to aid in the differentiation of tubercular meningitis from bacterial meningitis, highlighting factors such as duration of symptoms, presence of neurological impairment, CSF/blood glucose ratio, and CSF protein levels 9,14 . In summary, our study highlights the distinct clinical and laboratory profiles associated with viral, bacterial, and tubercular meningitis. ...