Xiaohui Su's research while affiliated with China Academy of Chinese Medical Sciences and other places
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Publications (16)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by a notably high disability rate, primarily attributed to cartilage and bone degradation. The involvement of heat shock protein 90 (HSP90) as a molecular chaperone in the inflammatory response of RA has been established, but its role in bone destruction remains uncertain. In the pres...
Ethnopharmacological relevance
A Chinese patent medicine derived from a classical traditional Chinese medicine formula, Yu-Xue-Bi tablet (YXB) is widely used in the clinic to treat rheumatoid arthritis (RA). During the progression of RA, angiogenesis plays a central role in fostering the production of inflammatory cells, leading to synovial hyperpl...
Growing evidence shows that Baihu-Guizhi decoction (BHGZD), a traditional Chinese medicine (TCM)-originated disease-modifying anti-rheumatic prescription, may exert a satisfying clinical efficacy for rheumatoid arthritis (RA) therapy. In our previous studies, we verified its immunomodulatory and anti-inflammatory activities. However, bioactive comp...
Ethnopharmacological relevance
Bone destruction plays a key role in damaging the joint function of rheumatoid arthritis (RA). Fengshi Qutong capsule (FSQTC) consisting of 19 traditional Chinese medicines has been used for treating RA in China for many years. Preliminary studies show that FSQTC has analgesic activity and inhibits synovial angiogenes...
An amendment to this paper has been published and can be accessed via the original article.
Accumulating studies have indicated that reactive oxygen species (ROS) may be implicated into the destructive pathological events of rheumatoid arthritis (RA). As an effective antioxidant, artesunate (ARS) was reported to exert antiarthritic effects. However, whether ARS attenuates the bone erosion during RA progression by regulating ROS production...
Background:
To identify biomarkers for guiding therapy and predicting clinical response of Tripterysium Glycosides Tablets (TGT) treatment is an urgent task due to individual differences in TGT response across rheumatoid arthritis (RA) patients. Competing endogenous RNA (ceRNA) regulatory system may influence drug response with involvement in dive...
Stem cell therapy may provide a novel therapeutic method for the replacement and regeneration of damaged neural cells in the central nervous system. However, insufficient stem cell migrating into the injured regions limits its applications. Although tetramethylpyrazine (TMP) originally isolated from Ligusticum walliichi (Chuanxiong) has been widely...
Osteoclasts, bone-specialized multinucleated cells, are responsible for bone destructive diseases such as rheumatoid arthritis and osteoporosis. Natural plant-derived products have received substantial attention given their potential therapeutic and preventive activities against bone destructive diseases. In the present study, we investigated the e...
Excessive bone resorption by osteoclasts within inflamed joints is the most specific hallmark of rheumatoid arthritis. A. flaccida has long been used for the treatment of arthritis in folk medicine of China; however, the active ingredients responsible for the anti-arthritis effects of A. flaccida are still elusive. In this study, W3, a saponin isol...
Buyang Huanwu Decoction (BYHWD) is a classic formula widely used for treating stroke-induced disability, the highest morbidity of neurological disorders in China. However, the mechanism of its neuroprotection has not been fully clarified. Previous reports indicated that it may promote growth and differentiation of neural precursor cells (NPCs). The...
Rheumatoid arthritis (RA) is characterized by a pre-vascular seriously inflammatory phase, followed by a vascular phase with high increase in vessel growth. Since angiogenesis has been considered as an essential event in perpetuating inflammatory and immune responses, as well as supporting pannus growth and development of RA, inhibition of angiogen...
Ethnopharmacological relevance and aim of the study:
Wen Luo Yin (WLY) is a traditional Chinese formula, which has the traditional use of scattering cold pathogen, draining dampness, freeing the flow of network vessels and relieving pains. It is extensively used in the treatment of rheumatoid arthritis (RA) patients for more than 2000 years, but i...
Citations
... CHE treatment demonstrated significant anti-osteoporotic activity. The main interventions of CHE on OVX rats involved the modulation of several key pathways, including biotin metabolism, as shown by biotin downregulation [183]. As previously reported, biotin can enhance the sperm motility and prolong the survival of frozen-thawed semen samples, which might be beneficial in the assisted reproductive technology field [184]. ...
... YuXueBi tablet decreased disease activity index, bone degradation and angiogenesis in CIA rats. Its anti-angiogenesis mechanism is believed to be the inhibition of CD31 and VEGF production as well as the inhibition of lysyl oxidase (LOX)/Ras/Raf-1 pathway (Su et al., 2022). Shexiang Zhuifeng analgesic plaster significantly decreased the concentrations of cytokines and VEGF in CIA rats, while also lowering the protein overexpression of the AKT/ mTOR/HIF-pathway. ...
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... Vitamin E has been proven to reduce oxidative stress responses in the liver and kidneys, thereby playing a protective role (40). Mangiferin can inhibit nuclear factor κB (NF-κB) and increase catalase activity to protect cells and has therapeutic significance in clinical practice (41,42). Unsaturated fatty acids can exert antioxidant effects on cell membranes. ...
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... Paw Swelling: the ipsilateral hindfoot thickness of the rats in each group was measured using Vernier callipers as previously reported, and these measurements were repeated three times [26]. The frequency of disease symptoms in each group of rats independent of severity indicated morbidity [27]. Clinical arthritis scores were assessed by two individuals who were blinded to the experimental groups [28]. ...
... Cao et al. reported that activation of Nrf2 and upregulation of HO-1 expression by AS contribute to the downregulation of cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS) levels, thereby exerting a protective effect in sepsis-associated lung injury [59]. Moreover, AS activated the p62/Nrf2 pathway to downregulate ROS levels, inhibiting osteoclastogenesis and ameliorating bone erosion in rheumatoid joints [60]. Notably, in a separate study, AS treatment at doses of 5 and 15 mg/kg reduced depression and anxietylike behaviors in rats, primarily attributed to AS's antioxidant effect [61]. ...
... ceRNA involved in Chinese medicine monomer treatment of RA Many ceRNA networks were linked to the treatment of T. wilfordii in RA. Zhang et al. suggested that the ceRNA network (lncRNA ENST0000494760/miR-654-5p/C1QC) is confirmed by the results obtained from microarray and was deemed to be a biomarker for RA response to Tripterysium Glycosides Tablets (TGT) by clinical cohort, in vitro and in vivo experiments [123]. Circ0003353 was confirmed as a key circRNA that reacted to inflammation and immunity in RA. ...
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... Numerous studies have established associations between certain herbs, including Astragalus, Chuanxiong, Ginseng and Salvia miltiorrhiza, and a range of potential diseases. For instance, Astragalus membranaceus has demonstrated efficacy in treating immune system and liver diseases [6][7][8], Ligusticum chuanxiong has shown promise in addressing neurological disorders [9], Panax ginseng has been linked to cardiovascular disease management [10] and Salvia miltiorrhiza has been indicated for cerebrovascular diseases [11]. Moreover, novel Chinese herbal medicines, such as Si-Ni-San, have exhibited therapeutic potential across multiple diseases [12][13][14]. ...
... Chang et al. have also conducted cell proliferation assays with human synovial cell lines [62]. The fluorescent microscopic technique has been used to detect morphological changes upon treatment with various polyphenols in various cancer and RA cell lines [63,64]. It has become an excellent technique for cell and tissue imaging and to observe biological processes. ...
... Anemone flaccida F. Schmidt is a perennial plant of the genus Anemone L. in the Ranunculacae family whose roots can be traditionally used as natural medicine. It is mainly rich in triterpenoid saponins, and it has been reported that A. flaccida F. Schmidt is effective in the prevention of RA by inhibiting bone differentiation and reconstruction (Kong et al., 2015;Liu et al., 2015). Research by Rao et al. has indicated that A. flaccida F. Schmidt effectively suppresses synovial proliferation and angiogenesis in arthritic joints and inhibited VEGFR/PI3K/AKT signaling pathway (Rao et al., 2023). ...
... BYHWD contains many substances, including glycosides, aglycones, polysaccharides, and alkaloids, but its active components have not yet been determined. Interestingly, BYHWD and its glycoside extracts have been shown to protect vessels damaged by AS Kong et al. 2014). Glycosides are the main pharmacologically active ingredients extracted from BYHWD, and the results of highperformance liquid chromatography (HPLC) showed that the glycosides in BYHWD were mainly ASV in Astragalus membranaceus (Fisch.) ...
