Xiao-Ming Bai's research while affiliated with Nanjing Medical University and other places
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Publications (4)
Prostaglandin E2 (PGE2) has been shown to influence cell invasion and metastasis in several types of cancer, including hepatocellular carcinoma (HCC). however, the molecular mechanisms underlying it remain to be further elucidated. Snail, as one of key inducers of epithelial-mesenchymal transition (EMT), plays pivotal roles in HCC invasion and meta...
Liver cancer is a common human cancer with a high mortality rate and currently there is no effective chemoprevention or systematic treatment. Recent evidence suggests that prostaglandin E2 (PGE2) plays an important role in the occurrence and development of liver cancer. However, the mechanisms through which PGE2 promotes liver cancer cell growth ar...
Cyclooxygenase-2 (COX-2)-controlled production of prostaglandin E(2) (PGE(2)) has been implicated in cell growth and metastasis in many cancers. Recent studies have found that COX-2 is co-expressed with survivin in many cancers. Survivin is a member of the inhibitor-of-apoptosis protein family. Some COX-2 inhibitors (e.g., celecoxib) can reduce the...
Prostaglandin E2 has been implicated in cell growth and metastasis in many types of cancers. However, the effects of PGE2 and its mechanism on cell adhesion, migration, and invasion have not been clarified yet. In this study, we found PGE2 treatment significantly increased the cell adhesion, migration, and invasion in hepatocellular carcinoma (HCC)...
Citations
... Te EP1 receptor activates protein kinase C by upregulating intracellular Ca 2+ while partially coupled to G protein Gαs. Te EP2 receptor activates the PKA pathway by increasing intracellular cAMP levels and partially coupling to G protein Gαs [72]. Te docking results showed that LJF components were well connected to EP1 and EP2 receptors. ...
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... AIMP2 expression is downregulated in gastric and colorectal cancer [78]. In liver cancer cells, treatment with prostaglandin E2, increases FUSE binding protein (FBP) and reduces AIMP2 expression, tilting the balance towards higher FBP expression, in turn inducing c-Myc [92]. TGF-β induces S156 phosphorylation of AIMP2 in HeLa cells, inducing release from the MSC and nuclear re-localization where it binds Smurf2 protein enhancing FBP ubiquitination and degradation [93]. ...
... It also decreases intracellular reduced glutathione (GSH), making cells more sensitive to oxidative stress (Fouad et al. 2013). In addition to TNFα, the inflammatory cascade activated by oxidative stress increases the expression of cyclooxygenase-2 (COX-2) and the production of inflammatory prostaglandins involved in HCC cell proliferation and metastasis (Bai et al. 2010;Guerriero et al. 2011;Lu et al. 2012;Nabi-Afjadi et al. 2021). ...
... Therefore, one means by which PGF 2α signaling may control cluster cohesion is by tightly regulating integrin-based adhesions. Supporting this idea, in cancer, PGs promote integrin adhesion stability (Mayoral et al., 2005;Bai et al., 2009;Liu et al., 2010). Second, these morphology changes may be due to PGF 2α signaling controlling actin cytoskeletal remodeling within the border cells. ...
