Xiao-Min Wang's research while affiliated with Taiyuan Normal University and other places
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Publications (285)
Background
Fibrosis has important pathoetiological and prognostic roles in chronic liver disease. This study evaluates the role of radiomics in staging liver fibrosis.
Method
After literature search in electronic databases (Embase, Ovid, Science Direct, Springer, and Web of Science), studies were selected by following precise eligibility criteria....
In this paper, we investigate the (2+1)- dimensional coupled nonlinear Schrödinger equations with variable coefficients which are used to describe the propagation of beams in inhomogeneous and nonlinear birefringent fibers, taking into account the components in the two polarized directions. To tackle this problem, we employ the Hirota bilinear meth...
Background
Neuropsychiatric symptoms (NPSs) belong to a category of non-motor symptoms of Parkinson's disease (PD), which seriously compromise the quality of life and prognosis of PD. This study focused on the correlations between NPSs, free radicals, neuroinflammatory factors, and neuropathological proteins in cerebrospinal fluid (CSF) in patients...
Previous studies have shown that reduced sleep duration, sleep fragmentation, and decreased sleep quality in patients with Alzheimer's disease are related to dysfunction in orexin signaling. At the same time, blood-brain barrier disruption is considered an early biomarker of Alzheimer's disease. However, currently no report has examined how changes...
Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracellular vesicles in a TSG101-dependent manner. The la...
Liver is the most common site of metastases of colorectal cancer, and liver metastases present with distinct histopathological growth patterns (HGPs), including desmoplastic, pushing and replacement HGPs and two rare HGPs. HGP is a miniature of tumor-host reaction and reflects tumor biology and pathological features as well as host immune dynamics....
Background
The aim of this study was to explore clinical features and potential mechanisms relating neuropathological biomarkers and blood-brain barrier (BBB) in Alzheimer’s disease (AD) and hearing loss (HL).
Materials and Methods
A total of 65 patients with AD were recruited and auditory function was assessed by threshold of pure tone audiometry...
With the acceleration of the aging society, neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), have become a rapidly growing global health crisis. Recent studies have indicated that microglia-neuron interactions are critical for maintaining homeostasis of the central nervous system. Genome-Wide Association St...
FAM107A may have a dual role in regulating the biological functions of tumors; however, its role in prostate adenocarcinoma (PRAD) remains unknown. We analyzed FAM107A expression by employing databases to clarify its potential prognostic value for PRAD, as well as its role in the pathogenesis of PRAD. We observed that the FAM107A expression level i...
Heparanase (HPSE), an endoglycosidase that cleaves heparan sulfate, regulates a variety of biological processes that promote tumor progression. In this study, we analyzed the correlation between HPSE expression and prognosis in cancer patients, using multiple databases (Oncomine, TIMER, PrognoScan, GEPIA, Kaplan-Meier plotter, miner v4.1, DAVID). H...
Peroxisome proliferator-activated receptor α (PPARα), a ligand-activated nuclear receptor critical for systemic lipid homeostasis, has been shown closely related to cardiac remodeling. However, the roles of cardiomyocyte PPARα in pressure overload-induced cardiac remodeling remains unclear because of lacking a cardiomyocyte-specific Ppara-deficient...
Background: Nanoparticle albumin-bound paclitaxel (nab-PTX) has exhibited clinical efficacy in breast cancer treatment, but toxicities can be yielded more at the same time. We did this meta-analysis aiming to unambiguously compare nab-PTX with conventional solvent-based paclitaxel (sb-PTX) in breast cancer patients of all stages.
Method: Pubmed, Em...
Developing an anode material with high-rate Li⁺ intercalation and stable charge/discharge platform is important for achieving high performance lithium ion capacitors (LICs). Reduced graphene oxide (rGO)-encapsulated MnO microspheres (∼2 μm) are obtained by a simple process including solvothermal and calcination techniques. The material contains a l...
Background Olfactory dysfunction (OD) is reported as a useful predictor for Alzheimer’s disease (AD). There are three sub-domains of olfaction: olfactory threshold, discrimination and identification. In AD patients, whether the performance of three sub-domains has different influential factors or relates to specific brain magnetic resonance imaging...
Proton exchange membrane fuel cell (PEMFC) has important implications for the success of clean transportation in the future. One of the key factors affecting the cost and performance of PEMFC is the cathode electrocatalyst for the oxygen reduction reaction (ORR) to overcome sluggish kinetics and instability in an acidic environment. As an essential...
Ethnopharmacological relevance
Astragalus mongholicus, Solanum nigrum Linn, Lotus plumule, Ligusticum are widely used traditional herbal medicines for cancer treatment in China. They were typical drugs selected from Gubenyiliu II and series of formula (GYII), which were developed on the foundation of YIQIHUOXUEJIEDU theory. In the present study, fo...
Raman spectroscopy is a fast, non-destructive and high-resolution characterization tool based on laser physics that can be applied to a wide range of materials science problems. It has proven to be an effective tool in studying phase transitions induced by variables such as temperature, pressure or electrochemical reactions. In-situ Raman spectrosc...
Background/Aim: Retinal nerve fiber layer (RNFL) thickness (RT), which can reflect the status of the retinal optic nerve cells, may be affected in patients with Alzheimer's disease (AD). There are few studies on the correlation of RT of patients with AD (AD-RT) with clinical symptoms of various cognitive domains, neuropsychiatric symptoms, and acti...
Under investigation in this paper is variable coefficient coupled nonlinear Schrödinger equations for the fiber couplers with asymmetric self-phase modulation and cross-phase modulation. With the developed Hirota bilinear method, bilinear forms and periodic two-soliton solutions are obtained. By choosing different parameters, we have discussed the...
Background and Purpose: Olfactory dysfunction (OD) is a common non-motor symptom of Parkinson disease (PD). However, the relationship between OD and neuropathologic proteins in cerebrospinal fluid (CSF) from PD patients remains unclear.
Methods: 166 PD patients were included in the study. Overall olfactory function was assessed by summing up the sc...
Background:
Chemotherapy-induced nausea and vomiting (CINV) is a common and distressing side effect. We conducted this clinical trial to compare the effectiveness of true acupuncture vs. sham acupuncture in controlling chemotherapy-induced nausea and vomiting (CINV) among patients with advanced cancer.
Methods:
A total of 134 participants were r...
A GO/Ni(HCO3)2 composite was synthesized by the self-assembly of layered Ni(HCO3)2 and GO in their suspension mixture under sonication, followed by heat treatment to obtain rGO/NiO for the use as the electrode material of supercapacitors. The structural change from the GO/Ni(HCO3)2 to the rGO/NiO was investigated by XRD, SEM, and nitrogen adsorptio...
Apathy is one of the most common symptoms of Alzheimer’s disease (AD), however, correlations of apathy with demographic variables, cognitive functions, neuropsychiatric symptoms, activity of daily living and olfactory functions in AD patients are still lacking comprehensive investigations. This is a cross-sectional study. Total 124 typical AD patie...
Background: To explore the changes of neuroinflammatory factors in cerebrospinal fluid (CSF) and their correlation with monoamine neurotransmitters in Parkinson's disease (PD) with depression (PD-D) patients. Methods: Neuroinflammatory factors and neurotransmitters in CSF were measured and compared between PD with no depression (PD-ND) and PD-D gro...
Background:
Apathy is common in Alzheimer's disease (AD) patients. However, its relation with other clinical symptoms in AD and brain structural changes in magnetic resonance imaging is unclear.
Results:
Compared with AD with no apathy group, cognitive function and activities of daily living were significantly impaired and neuropsychiatric sympt...
Triple‑negative breast cancer (TNBC), which is characterized by inherently aggressive behavior and lack of recognized molecular targets for therapy, poses a serious threat to women's health worldwide. However, targeted treatments have yet to be made available. A crosstalk between tumor cells and platelets (PLT) contributing to growth, angiogenesis...
Effective treatments for chemotherapy-induced peripheral neuropathy (CIPN) remain unavailable. Given the significance of spinal cord glutamate transporters in neuronal plasticity and central sensitization, this study investigated the role of excitatory amino acid transporter 2 (EAAT2) and vesicular-glutamate transporter 2 (VGLUT2) in the developmen...
Background
Biomarkers which can robustly predict the recurrence of stage II colorectal cancer (CRC) have been urgent needed. Immune cells highly related to the recurrence and prognosis of CRC. However, whether the immune cells take part in the recurrence of stage II CRC has not known.Methods
Explored the roles and possible mechanism of immune cells...
Purpose
Accumulating studies have explored the potential diagnostic value of lncRNA MALAT1 in various cancers. However, there are still inconsistent results in diagnostic accuracy and reliability in individual studies. The aim of this pooled study was to summarize the overall diagnostic capacity of lncRNA MALAT1 in cancer detection and diagnosis....
Active neural stem cells (aNSCs) and quiescent neural stem cells (qNSCs) are two distinct subpopulations found in the adult hippocampal dentate gyrus (DG). However, to date, no cell surface marker has been established to identify and profile qNSCs in the adult hippocampus. Here, we identified expression of vascular cell adhesion molecule 1 (VCAM1)...
Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, angiogenesis and metastasis. Much of the impact of heparanase on tumor progression is related to its function in mediating tumor-host crosstalk, priming the tumor microenvironment to better support tumor growth and met...
Objective:
To investigate the expression level of miR-181b in CD19+ B lymphocytes of patients with chronic lymphocytic leukemia (CLL), to analyze the relationship between its expression and the prognosis of CLL patients, and to predict the potential target gene of miR-181b in CLL by using bioinformatics.
Methods:
Eight-four patients with CLL tre...
In this paper, we investigate coupled nonlinear Schrödinger equations for the fiber couplers with asymmetric self-phase modulation and cross-phase modulation. A class of vector soliton solutions including bright-bright (BB), bright-dark (BD), dark-bright (DB) and breather-like (BL) solitons are generated by the developed Hirota bilinear method. Und...
Invited for this month's cover picture is the group of Shi‐Bin Liu and Ding Zhang from Taiyuan University of Technology (China). The cover picture shows that the 4d‐cation Zr‐substitution shows high promotion on the electrochemical performance of tunnel‐type transition metal oxides as promising cathodes for sodium‐ion batteries. Read the full text...
The Front Cover shows that 4d‐cation Zr substitution greatly promotes the electrochemical performance of tunnel‐type transition metal oxides, making them promising cathodes for sodium‐ion batteries. Zr introduction not only facilitates Na+ diffusion kinetics but also decreases the structural changes during the electrode process, thus resulting in s...
Tumor-derived extracellular vesicles are important mediators of cell-to-cell communication during tumorigenesis. Here, we demonstrated that hepatocellular carcinoma (HCC)-derived ectosomes remodel the tumor microenvironment to facilitate HCC progression in an ectosomal PKM2-dependent manner. HCC-derived ectosomal PKM2 induced not only metabolic rep...
Ethnopharmacological relevance
The Scutellaria barbata and Hedyotis diffusa (SH) herb pair is extensively used in Traditional Chinese Medicine for both efficacy enhancement and toxicity reduction, of TCM widely using for efficacy enhancing and toxicity reducing in breast cancer treatment in China and Asian countries. Superior clinical efficacy obse...
Sodium‐ion batteries (SIBs) using transition metal oxides as cathodes have been considered as prospective alternatives for energy storage applications. Herein, the 4d‐cation Zr‐substitution strategy is proposed to optimize the structure and electrochemical properties of Na0.44MnO2 for the first time. In‐situ X‐ray diffraction demonstrates that the...
Objective:
To explore the value of CpG-oligonucleotide(CpG-ODN) immunostimulatory method in chromosome culture of chronic lymphocytic leukemia (CLL) cells and to compare the differences between related studies at home and abroad, so as to improve the success rate of CLL karyotype culture and the detection rate of abnormal karyo-types.
Methods:
B...
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Orphan nuclear receptor Nur77, which is low expressed in HCC, functions as a tumor suppressor to suppress HCC. However, the detailed mechanism is still not well understood. Here, we demonstrate that Nur77 could inhibit HCC development via transcriptio...
Objective:
To study the effect and mechanism of Huayu Wan (, HYW) in combination of chemotherapy of tumor treatment.
Methods:
HYW serum was added in Lewis cells to assess its impact on fluorescent doxorubicin delivery in vitro. Then, Lewis tumor cells was implanted in C57BL/6 mice via xenograft transplantation. Tumor growth was measured and sign...
Objective:
To test whether self-administered acupressure reduces stress and stress-related symptoms in caregivers of older family members.
Design:
In this randomized, assessor-blind, controlled trial, 207 participants were randomized (1:1) to an acupressure intervention or a wait-list control group.
Setting:
Community centers in Hong Kong, Chi...
Background:
Nausea and vomiting are the most common complications following chemotherapy and usually lead to decreased quality of life. Acupuncture therapy is an effective method for chemotherapy-induced nausea and vomiting (CINV), the effects and safety have been observed by many clinicians and demonstrated in a systematic review, which was inclu...
Under investigation in this paper is the variable coefficient three-coupled nonlinear Schrödinger (CNLS) equations, which govern the dynamics of solitonic excitations along three-spine [Formula: see text]-helical protein with inhomogeneous effect. Via the Hirota method and symbolic computation, the exact two-bright-one-dark (TBD) and one-bright-two...
Gambogic acid (GA) is a potential anti-cancer compound that is extracted from the resin of Garciania hanburyi. The present study was designed to evaluate the anti-metastatic effect of GA on melanoma cell lines in vitro and to explore the underlying mechanism. The anti-proliferative activity of GA on melanoma cells was assessed by CCK-8 assay. The W...
Fat mass and obesity-associated protein (FTO) has been well known for a pivotal role in regulation of fat mass, adipogenesis and body weight. In recent years, increasing studies revealed a strong association between FTO and various types of cancer. Its role in human hepatocellular carcinoma, however, remains unclear. We aimed at investigating the e...
Chemotherapy-induced cognitive impairment, also known as “chemobrain,” is a common side effect. The purpose of this study was to examine whether ginsenoside Rg1, a ginseng-derived compound, could prevent chemobrain and its underlying mechanisms. A mouse model of chemobrain was developed with three injections of docetaxel, adriamycin, and cyclophosp...
The development of a renewable absorbent with a high adsorption efficiency is of great importance for the purification of dye wastewater. A nitrogen-doped graphene aerogel (N-GA) was prepared by a one-step hydrothermal and freeze-drying method using polyvinyl alcohol (PVA) as a cross-linking agent. Results indicated that the nitrogen doping provide...
Anion-doping strategy represents one efficient route to adjust the structure of electrode material for advanced reversible batteries. The work herein obtains an optimized F-doping sodium manganese oxide Na 0.44 MnO 1.93 F 0.07 with a layer-tunnel hybrid structure, and the essential factors such as synthesis temperature and crystal structure which d...
Deficiency of deleted in liver cancer 2 (DLC2), a novel domain to inhibit RhoA activity, plays an important role in inflammatory pain. However, the underlying mechanisms remain unclear. This study investigated the role of DLC2 and its downstream cascade of RhoA/ROCK in formalin-induced inflammatory pain using DLC2-knockout (DLC2-/-) mice and compar...
Mounting evidence suggests that synaptic plasticity provides the cellular biological basis of learning and memory, and plasticity deficits play a key role in dementia caused by Alzheimer's disease. However, the mechanisms by which synaptic dysfunction contributes to the pathogenesis of Alzheimer's disease remain unclear. In the present study, Alzhe...
Many studies have shown that (5R)-5-hydroxytriptolide is the optimal modified analogue of triptolide, possessing comparable immunosuppressive activity but much lower cytotoxicity than triptolide. Whether (5R)-5-hydroxytriptolide has preventive effects on neuroinflammation is unclear. This study was designed to pretreat primary astrocytes from the b...
Identification of primary astrocytes (immunocytochemical staining).
Primary astrocytes were determined by glial fibrillary acidic protein. Bar:20 μm.
LLDT-8 reduced LPS-induced NO generation, TNF-α and IL-1β release, and inhibited microglia activation by detecting CD11b.
(A) NO generation; (B) TNF-α expression; (C) and IL-1β expression; (D) CD11b expression. Data represent the mean ± SEM, and analyzed by one-way analysis of variance followed by Newman-Keuls post hoc test. The experiment was repe...
Chemotherapy-induced cognitive impairment, often referred to as "chemobrain," is a common side effect. In this study, mice received three intraperitoneal injections of a combination of docetaxel, adriamycin, and cyclophosphamide (DAC) at 2-day intervals. A water maze test was used to examine cognitive performance, and manganese-enhanced magnetic re...
To address the safety concern for room‐temperature sodium‐sulfur battery, such as fires easily triggered by organic electrolytes, an applicable nonflammable electrolyte formula was developed by introducing proper trimethyl phosphate (TMP) into 1.0 M NaClO4‐ethylene carbonate/propylene carbonate electrolyte. It is demonstrated that electrolyte conta...
A proper animal model is crucial for a better understanding of diseases. Animal models established by different methods (subcutaneous injections, xenografts, genetic manipulation, chemical reagents induction, etc.) have various pathological characters and play important roles in investigating certain aspects of diseases. Although no single model ca...
Background
Parkinson’s disease (PD) is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions (Lewy bodies) within some remaining neurons in the substantia nigra. Recently, astroglial inclusion body has also been found in some neurodegenerative diseases including PD. However, the underlying molecular me...
Background
Total intravenous anaesthesia with propofol has been shown to reduce postoperative pain in some clinical studies, but knowledge of its underlying analgesic mechanism remains limited. In this study, we compared the analgesic effects of propofol versus isoflurane in an animal model of postoperative pain and evaluated its underlying molecul...
Room-temperature sodium‑sulfur (RT Na-S) battery is a promising candidate for large-scale energy storage applications due to its high theoretical specific energy, low cost, and environmental benefits. Here the effect of fluoroethylene carbonate (FEC) as an additive in 1.0 M NaClO4-ethylene carbonate/propylene carbonate (EC/PC, V/V = 1/1) electrolyt...
Background:
Olfactory dysfunction is common in patients with Alzheimer's disease (AD). However, the relationship between olfactory dysfunction (OD) and clinical symptoms and the potential mechanisms of OD of AD are still unknown.
Objective:
To explore the relationship between olfactory dysfunction and clinical symptoms and the potential mechanis...
Under investigation in this paper are the three-coupled nonlinear Schrödinger (CNLS) equations, which govern the dynamics of solitonic excitations along three-spine α-helical protein with inhomogeneous effect. The vector periodic solitons (VPSs) of three-CNLS equations have been obtained by a transformation that transforms the corresponding equatio...
OBJECTIVE
Contralateral C7 (CC7) nerve root has been used as a donor nerve for targeted neurotization in the treatment of total brachial plexus palsy (TBPP). The authors aimed to study the contribution of C7 to the innervation of specific upper-limb muscles and to explore the utility of C7 nerve root as a recipient nerve in the management of TBPP....
Electrical stimulation could enhance nerve regeneration and functional recovery. The objective of this study was to evaluate the regenerative effects of implanted electrodes with different contacts in resected sciatic nerve. Sciatic nerve resection and microsurgical repair models were established and randomly divided into four groups (point contact...
Objective:
To assess the effectiveness of Yishen Jiangu Granules (, YSJGG) on aromatase inhibitor-associated musculoskeletal symptoms (AIMSS).
Methods:
A single-arm, open-label study was conducted in 34 postmenopausal women with breast cancer who experienced AIMSS. Patients were treated with YSJGG for 12 weeks (12.4 g orally twice daily). The pr...
Remifentanil, an ultra-short acting opiate, has been reported to protect against hepatic ischemia-reperfusion injury, which is a major cause of postoperative liver dysfunction. The objective of this study was to determine whether a central vagal pathway is involved in this protective procedure. Rat models of hepatic ischemia-reperfusion were used i...
Background:
The aim of this study was to evaluate the diagnostic accuracy of magnetic resonance (MR) imaging-based methods for detecting steatosis and fibrosis in nonalcoholic fatty liver disease (NAFLD).
Methods:
Data were extracted from research articles obtained after a literature search from multiple electronic databases. Random-effects meta...
Primary immune thrombocytopenia (ITP) is a bleeding disorder commonly encountered in clinical practice. The International Working Group (IWG) on ITP has published several landmark papers on terminology, definitions, outcome criteria, bleeding assessment, diagnosis, and management of ITP. The Chinese consensus reports for diagnosis and management of...
A number of murine models are used to mimic the pathology of breast cancer. Tissue inoculation and cell inoculation using orthotopic implantation (OS) and subcutaneous implantation (SQ) are commonly used to generate murine models to investigate cancer. However, limited information is available in regard to the variations of these methods. The prese...
Quantum coherence and nonlocality are two intriguing features of quantum mechanics. We relate the nonlocal advantage of quantum coherence (NAQC) to Bell nonlocality, and show geometrically that the NAQC created by the local von Neumann measurements on one subsystem of a two-qubit state exhibits quantum correlation which is stronger than Bell nonloc...
Background:
Chemokine CXC receptor 4 (CXCR4) in spinal glial cells has been implicated in neuropathic pain. However, the regulatory cascades of CXCR4 in neuropathic pain remain elusive. Here, we investigated the functional regulatory role of miRNAs in the pain process and its interplay with CXCR4 and its downstream signaling.
Methods:
miRNAs and...
Fatigue, the most common side effect of cancer treatments, is observed to intensify during external-beam radiation therapy (EBRT). The underlying molecular mechanisms remain unclear. This study investigated the differentially expressed genes/proteins and their association with fatigue intensification during EBRT. Fatigue scores measured by FACT-F a...
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. For decades, the unilateral 6‑hydroxydopamine (6‑OHDA) rat model has been employed to investigate the pathogenesis and therapy of PD. However, the behavior and associated pathological features of the model long term have not previously been described dynamically. In the...
A strong link between histone deacetylases (HDACs) and nociceptive hypersensitivity has been indicated in different pain models. However, the underlying molecular and cellular mechanisms remain elusive. Here, we discovered that partial sciatic nerve ligation-induced mechanical allodynia and thermal hyperalgesia in mice were associated with increase...
Total focusing method (TFM) has improved resolution and accuracy over traditional ultrasonic phased array technology. In this paper, an advanced parallel architecture in field programmable gate arrays is suggested to significantly accelerate the imaging efficiency of TFM. Several techniques are investigated, including the real-time concurrent calcu...
Na0.44MnO2 has aroused global interest as a promising cathode material for sodium ion batteries due to its unique tunnel structure. Rod-like Na0.44MnO2 is synthesized here via a simple, fast and environment-friendly oxalate precursor-based process, and the electrochemical performances, as well as the structural evolution within the electrode redox...
Colon cancer arises from the accumulations of genetic and epigenetic changes. Currently, profiles of DNA methylation and gene expression of colon cancer have not been elucidated clearly. This articles aims to characterize the profile of DNA methylation and gene expression of colon cancer systemically, and acquire candidate genes potentially regulat...
Propofol, an intravenous anesthetic, has been shown to offer superior analgesic effect clinically. Whether propofol has preventive analgesic property remains unexplored. The present study investigated the antinociceptive effect of propofol and underlying molecular and cellular mechanisms via pre-emptive administration in a formalin-induced inflamma...
Long noncoding RNAs (lncRNAs) are a new class of regulatory noncoding RNAs. Emerging evidences indicate that lncRNAs play a critical role in the development of hepatocellular carcinoma (HCC). Although several lncRNAs have been annotated, the association of most lncRNAs with HCC is unknown. In this study, we investigated lncRNA alterations in HCC by...
Citations
... 2D emerging MXene is considered a feasible substrate for lithium stabilization due to its excellent electronic conductivity, large interlayer spacing that facilitates fast mass transfer, good mechanical properties, and abundant terminal groups. [42] However, when MXene nanosheets form closely stacked films, the limited lithium-friendly functional groups (such as hydroxyl groups buried on the surface) are not sufficient to affect the growth behavior of the metal. Wei et al. used ultrasonic dispersion and filtration to disperse 2D imine COF particles (COF-LZU1) into MXene films (MF) to form composites (MCF, Figure 3e). ...
... angiogenesis-related genes with prognostic significance. Among these 10 angiogenesis-related genes, studies have reported that QSOX1, GLIS1 and FAM107A can be used as prognostic markers for PRAD patients (37)(38)(39). In recent years, the concept of precision medicine has emphasized subgroup typing of individual research subjects. ...
... Third, a critical goal is to reduce the detectability (radio-masking) of military equipment by reducing the reflection of radar signals, which is one of the most sensitive issues faced by all nations in the military field, known as stealth [16,17]. Therefore, the development of high-quality materials capable of absorbing EMWs over a wide frequency range [18,19] is critical to human health and national security [20,21]. ...
... Progressive deterioration of executive function and motivation disorders are also developed (Wang et al. 2022). A range of neuropsychiatric disorders, including agitation, olfactory dysfunction, dyspraxia, sleep disorders, and motor dysfunctions are developed during AD neuropathology (Yu et al. 2021;. Old age, smoking, depression, family history, head injury, and cardiometabolic disorders are the main risk factors for the development of AD (Silva et al. 2019). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272781766033415-1442047649216_Q64/Weiping-Zhang-6.jpg)
... We monitored minute-to-minute fluctuations in reagent optical density as measured at 480 nm and compared them to those seen in a blank. Findings are shown in terms of superoxide dismutase activity units (milligram per protein) [17]. One unit of SOD activity, or SOD activity, partly inhibited adrenaline. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281190722996-1695458145735_Q64/Wei-Zhang-1002.jpg)
... MMP10 could be released by endothelial cells derived from the BBB, regulating the activation of brain-derived growth factors, enzyme degradation, and extracellular matrix remodeling, all of which are essential for the integrity of the BBB, neural network repair, and tissue formation [42,43]. It has been reported that in AD, Aβ disrupts the integrity of the BBB by activating MMP10, and the overexpression of MMPs degrades tight junction proteins, damages endothelial cells, leading to excessive opening of the BBB, thereby exacerbating neuroin ammation and neurotoxicity [44]. This leads to an increase in the number of aged astrocytes, causing synaptic dysfunction, neuronal damage, and ultimately neuronal death [45,46]. ...
... within cells, cargo is selectively incorporated into evs, which provide a protective shield from degradation. Several mechanisms for ev cargo selection have been described: lipid modifications of proteins, for instance, GPi-anchor [11]; fatty acid modifications such as palmitoylation, acylation or myristoylation [12][13][14]; specific sequences in nucleic acids, such as the so-called eXOmotifs in miRNAs [15,16]; or other protein modifications that allow their sorting into late endosomes [17,18]. the different types of biomolecules (nucleic acids, proteins, lipids) carried in vesicles can be used to know their tissue or cellular origin. ...
... For instance, they can be used for the detection of explosives, and hazardous and flammable gases [1][2][3][4]. One of the most dangerous and extremely flammable gases is H2S or hydrogen sulfide [5,6]. This gas can harm and irritate the skin, eyes, mucous membranes, and even the nervous system [7,8]. ...
... Colorectal cancer (CRC) is the third most common malignant tumor in the world, with an increasing incidence and deaths year-on-year. 1 A combination of chemotherapy and radiotherapy, as well as biological targeting therapies, are commonly used in clinical CRC treatment to improve the quality and duration of patients survival. 2 Moreover, drugs with lower toxicity and better targeting effects for chemotherapy or that assist radiotherapy are being sought and developed to enhance treatment efficacy and safety. ...
... Moreover, deaf APP/ PS1 mice showed increased Aβ deposition and synaptic degeneration. These results are consistent with the clinical observations that patients with AD with hearing loss showed enhanced Aβ deposition and loss of brain volume [47][48][49] . Interestingly, deafness increased both the mRNA and protein levels of APP in both WT and APP/PS1 transgenic (TG) mice, indicating that the effects of deafness on APP expression are not specific to the APP overexpression mouse model. ...
