Xianyou Zheng's research while affiliated with Shanghai Jiao Tong University and other places
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Publications (75)
Chemotherapy is an important therapeutic approach for malignant tumors for it triggers apoptosis of cancer cells. However, chemotherapy also induces senescence of stromal cells in the tumor microenvironment to promote tumor progression. Strategies aimed at killing tumor cells while simultaneously eliminating senescent stromal cells represent an eff...
Excessive neuroinflammation after spinal cord injury (SCI) is a major hurdle during nerve repair. Although proinflammatory macrophage/microglia-mediated neuroinflammation plays important roles, the underlying mechanism that triggers neuroinflammation and aggravating factors remain unclear. The present study identified a proinflammatory role of sema...
Background
Failure of digit replantation after traumatic amputation is difficult to predict. We aimed to develop a prognostic model to better identify factors that better predict replantation failure following traumatic digit amputation.
Materials and methods
In this multicenter prospective cohort, we identified patients who had received digit rep...
Background
Ulnar nerve transposition is used for cubital tunnel syndrome (CuTS) with nerve instability. The aim is to report a modified technique for ulnar nerve transposition using medial intermuscular septum and Osborne's ligament as a double-strand helix sling to recreate a sliding channel for the ulnar nerve and the functional outcomes at follo...
The effective management of osteomyelitis remains extremely challenging due to the difficulty associated with treating bone defects, the high probability of recurrence, the requirement of secondary surgery or multiple surgeries, and the difficulty in eradicating infections caused by methicillin‐resistant Staphylococcus aureus (MRSA). Hence, smart b...
Aims
To investigate the efficacy of ethylenediaminetetraacetic acid-normal saline (EDTA-NS) in dispersing biofilms and reducing bacterial infections.
Methods
EDTA-NS solutions were irrigated at different durations (1, 5, 10, and 30 minutes) and concentrations (1, 2, 5, 10, and 50 mM) to disrupt Staphylococcus aureus biofilms on Matrigel-coated gla...
Osteoarthritis (OA) is an age-related degenerative disease without disease-modifying therapy. The lack of aging-induced osteoarthritis models makes the discovery of therapeutic drugs more challenging. The deficiency of ZMPSTE24 could induce Hutchinson–Gilford progeria syndrome (HGPS), a genetic disorder of rapid aging. However, the relationship bet...
Background
The extensive functional and structural remodeling that occurs in the brain after amputation often results in phantom limb pain (PLP). These closely related phenomena are still not fully understood.
Methods
Using magnetic resonance imaging (MRI) and graph theoretical analysis (GTA), we explored how alterations in brain cortical thicknes...
Objective:
Humeral fractures are common in arm wrestling and other sports and military activities requiring similar movements; however, the precise mechanism is poorly understood. Here, we present an overview of the characteristics, possible mechanisms, and treatment of humeral shaft fractures sustained during arm wrestling.
Methods:
We reviewed...
Introduction and importance:
Severe limb trauma results in mangled extremities, amputation, uncovered wound and delayed healing. The rapid development of flap transplantation concept and technique leads to applications of free flap in the salvage of limb and articular appearance and functions. This report discusses the case of a patient with acute...
Introduction:
This study aimed to investigate the incidence of deep vein thrombosis (DVT) in patients with pelvic or lower-extremity fractures in the emergency intensive care unit (EICU), explore the independent risk factors for DVT, and investigate the predictive value of the Autar scale for DVT in these patients.
Methods:
The clinical data of...
Hand flexor tendon injuries are common and biomechanically challenging to achieve good functional outcomes. Several approaches using the Pennington-modified Kessler repair technique have been attempted, but high-level evidence is still lacking. Here, we evaluated the relative efficacy of 3 versions of the Pennington-modified Kessler technique in re...
The polarization of microglia plays an important role in the outcome of ischemic stroke (IS). In the aged population, senescent microglia show a predominant pro-inflammatory phenotype, which leads to worse outcomes in aged ischemic stroke compared to young ischemic stroke. Recent research demonstrated that inducible pluripotent stem cell-derived sm...
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Background
Management of recalcitrant diabetic foot ulcers remains challenging. Tibial transverse transport (TTT) is an effective method for enhancing the healing of foot ulcers. This retrospective study reports a novel triplanar osteotomy in the tibia and assesses the clinical outcomes of TTT for diabetic foot ulcers.
Methods
Fifty-nine patients...
Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells (BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2 ( Msi2 ) regulates BMSC lineage...
Osteosarcoma (OS) is a common bone cancer in children and adolescents, and metastasis and recurrence are the major causes of poor treatment outcomes. A better understanding of the tumor microenvironment is required to develop an effective treatment for OS. In this paper, a single-cell RNA sequencing dataset was taken to a systematic genetic analysi...
Aims
To evaluate inducing osteoarthritis (OA) by surgical destabilization of the medial meniscus (DMM) in mice with and without a stereomicroscope.
Methods
Based on sample size calculation, 70 male C57BL/6 mice were randomly assigned to three surgery groups: DMM aided by a stereomicroscope; DMM by naked eye; or sham surgery. The group information...
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Background: Management of recalcitrant diabetic foot ulcers remains challenging. Tibial transverse transport (TTT) has been verified as an effective method for enhancing the healing of foot ulcers. This retrospective study reported a novel triplanar osteotomy in the tibia and assessed the clinical outcomes of TTT for diabetic foot ulcers.
Methods:...
Objective:
To review the advances of the role of mitochondrial dysfunction in the spinal cord injury (SCI) and its relevant treatments.
Methods:
Focusing on various mechanisms of mitochondrial dysfunction, recent relevant literature at home and abroad was identified to summarize the therapeutic strategies for SCI.
Results:
Mitochondrial dysfun...
Osteoarthritis (OA) is an age-related degenerative disease without disease-modifying therapy. The lack of aging-induced osteoarthritis models makes the discovery of therapeutic drugs more challenging. The deficiency of integral membrane zinc metalloprotease ZMPSTE24 could induce Hutchinson-Gilford progeria syndrome (HGPS), a genetic disorder of rap...
Objective:
To investigate the effect of M2-like macrophage/microglia-derived mitochondria transplantation in treatment of mouse spinal cord injury (SCI).
Methods:
BV2 cells were classified into M1 (LPS treatment), M2 (IL-4 treatment), and M0 (no treatment) groups. After receiving M1 and M2 polarization, BV2 cells received microscopic observation...
Background
In traumatic spinal cord injury (SCI), secondary injuries, including vascular injury, cellular death, mitochondrial dysfunction, and vascular injury, have been considered as important causes of impaired functional recovery after SCI. Postinjury angiogenesis has been considered to be a potential strategy for SCI treatment. New-born vessel...
Inhibitors that target diabetes pathology-related signaling pathways have great therapeutic potential for diabetic wound healing. Metal—organic frameworks (MOFs) are increasingly popular drug delivery systems that have high loading capacity and can release their intrinsic metal ions to act as bioactive agents. In light of this, a receptor for advan...
Objective
Common peroneal nerve (CPN) injury that leads to foot drop is difficult to manage and treat. We present a new strategy for management of foot drop after CPN injury. The soleus muscular branch of the tibial nerve is directly transferred to the deep fibular nerve, providing partial restoration of motor function.
Methods
We retrospectively...
Aims Trained immunity confers non-specific protection against various types of infectious diseases, including bone and joint infection. Platelets are active participants in the immune response to pathogens and foreign substances, but their role in trained immunity remains elusive. Methods We first trained the innate immune system of C57BL/6 mice vi...
Background
Microsurgical anastomosis is technically difficult especially for less-experienced surgeons. Traditionally, surgeons in training could only accomplish these surgeries under intensive guiding and supervision from senior surgeons. This study presents and characterises a new method for microsurgical trainees to objectively evaluating the qu...
Background:
The presence of Type II diabetes is a well-established risk factor for bone and joint infection, especially in patients with poor glycemic control. However, few studies have investigated the effect of the duration of preoperative glycemic intervention. For patients with poor glycemic control, the effect of the duration of preoperative...
Background
Traumatic digit amputations can result in significant impairment. Optimal surgical treatment is unclear for certain digits in various amputation patterns. Our aim was to compare the contribution of revision amputation vs replantation for each particular digit to functional outcomes.
Materials and methods
Prospective cohort study at thre...
A major reason that hinders the clinical application of disease-modifying osteoarthritis drugs (DMOADs) is the unmet challenges in their effective delivery to cartilage. Cationic macromolecules represent promising carriers to enhance the drug delivery to cartilage through their electrostatic interaction with the negatively charged cartilage matrix....
Background
Osteogenesis is tightly coupled with angiogenesis during bone repair and regeneration. However, the underlying mechanisms linking these processes remain largely undefined. The present study aimed to test the hypothesis that epidermal growth factor-like domain-containing protein 6 (EGFL6), an angiogenic factor, also functions in bone marr...
The right parietal lobe plays an important role in body image, and disorders of body image emerge after lesions in the parietal lobe or with parietal lobe epilepsy. Body image disorder also often accompanies upper-limb amputation, in which the patient misperceives that their missing limb is still part of their body. Cortical reorganization is known...
Background: Mitochondrial dysfunction and macrophage/microglia mediating inflammation are critical pathological process components of secondary injury in spinal cord injury (SCI), which lead to impaired regeneration and function recovery. Mitochondria is essential to macrophage/microglia metabolism and polarization. However, there are few research...
Objective:
To investigate clinical application of the free peroneal artery perforator flap in soft tissue defect of foot and ankle.
Methods:
The clinical data of 18 patients with soft tissue defects of foot and ankle who were repaired with free peroneal artery perforator flaps between March 2019 and March 2020 were retrospectively analyzed. Amon...
Background:
Amputation in adults is a serious procedure or traumatic outcome, one that leads to a possible "remapping" of limb representations (somatotopy) in the motor and sensory cortex. The temporal and spatial extent underlying reorganization of somatotopy is unclear. The aim of this study was to better understand how local and global structur...
Objective:
To explore the potential therapeutic effects of endothelial progenitor cells derived small extracellular vesicles (EPCs-sEVs) on spinal cord injury in mice.
Methods:
EPCs were separated from femur and tibia bone marrow of 20 C57BL/6 male mice, and identified by double fluorescence staining and flow cytometry. Then the EPCs were passag...
Background: Osteogenesis is tightly coupled with angiogenesis during bone repair and regeneration. However, the underlying mechanisms linking these processes remain largely undefined. The present study aimed to test the hypothesis that epidermal growth factor-like domain-containing protein 6 (EGFL6), an angiogenic factor, also functions in bone mar...
Aims
In wound irrigation, 1 mM ethylenediaminetetraacetic acid (EDTA) is more efficacious than normal saline (NS) in removing bacteria from a contaminated wound. However, the optimal EDTA concentration remains unknown for different animal wound models.
Methods
The cell toxicity of different concentrations of EDTA dissolved in NS (EDTA-NS) was asse...
Background:
The innate immune system can recall previous immunologic challenges and thus respond more effectively to subsequent unrelated challenges, a phenomenon called trained immunity. Training the innate immune system before surgery might be a potential option to prevent bone and joint infection.
Questions/purposes:
(1) Does the training pro...
Piezoelectric materials can produce electrical power from the mechanical stimulation and thus, they may accelerate electroactive tissue healing as a promising treatment for traumatic peripheral nerve injuries. In this study, a piezoelectric zinc oxide nanogenerator scaffold is manufactured by 3D injectable multilayer biofabrication. The piezoelectr...
Aims
The purpose of this study was to determine whether intracellular Staphylococcus aureus is associated with recurrent infection in a rat model of open fracture.
Methods
After stabilizing with Kirschner wire, we created a midshaft femur fracture in Sprague-Dawley rats and infected the wound with green fluorescent protein (GFP)-tagged S. aureus....
Background:
To mitigate the possibility of infection after arthroplasty, intraoperative irrigation is essential to remove contaminating bacteria. Previous studies have demonstrated that irrigation with an EDTA solution before wound closure is superior to irrigation with normal saline in removing contaminating bacteria in a rat model of open fractu...
Background: Amputation in adults is a serious condition and most patients were associated with the remapping of representations in motor and sensory brain network.
Methods: The present study includes 8 healthy volunteers and 16 patients with amputation. We use resting-state fMRI to investigate the local and extent brain plasticity in patients suffe...
Background: Amputation in adults is a serious condition and previous studies suggested a remapping of representations in motor and sensory brain networks. However, little is known about the longitudinal reorganizing pattern in upper limb amputees’ patients.
Methods: The present study included 8 healthy volunteers and 16 patients with amputation. We...
Lower extremity soft-tissue defects were clinically common, caused mainly by machine injury, burn and other diseases. Treatment of high-energy lower extremity trauma with soft-tissue defects and exposure of tendon, nerve and bone remains a formidable problem. Since the development of microsurgical techniques from 1960s, local flaps, microvascular f...
Background:
Opioids and acetaminophen are both widely used to relieve pain after non-operative treatment of limb fractures, but evidence for the superiority of opioids versus acetaminophen is lacking. In this study, we aim to determine whether acetaminophen is non-inferior to the acetaminophen/oxycodone combination for pain relief after non-operat...
Objective:
To investigate the effect of the sciatic nerve elongation on pain in rats.
Methods:
Thirty-six adult male Wistar rats of SPF grade, weighing 250-300 g. Eighteen of them were randomly divided into 3 groups, 6 rats in each group. They were sciatic nerve elongation group (group A), nerve no-elongation group (group B), and nerve ligation...
Backgroud Opioids and acetaminophen are both widely used to relieve pain after nonoperative treatment of limb fractures, but evidence for superiority of opioids versus acetaminophen is lacking. In this study we aim to determine whether acetaminophen is noninferior to the acetaminophen/oxycodone combination for pain relief after nonoperative fixatio...
Background:
Generally, surgeons assess the quality of vascular anastomosis in digit replantation on the basis of their experience.
Description:
The steps for replantation of a completely amputated thumb, with assistance of high-speed video recording, consist of (1) debridement, (2) fixation, (3) tendon suture, (4) anastomosis, and (5) wound clos...
Background: Opioids and acetaminophen are both widely used to relieve pain after nonoperative treatment of limb fractures, but evidence for superiority of opioids versus acetaminophen is lacking. In this study we aim to determine whether acetaminophen is noninferior to the acetaminophen/oxycodone combination for pain relief after nonoperative fixat...
Background: Opioids and acetaminophen are both widely used to relieve pain after nonoperative treatment of limb fractures, but evidence for superiority of opioids versus acetaminophen is lacking. In this study we aim to determine whether acetaminophen is noninferior to the acetaminophen/oxycodone combination for pain relief after nonoperative fixat...
Background:
Prescription of opioid analgesics is currently a common practice to relieve pain for musculoskeletal injuries in many regions of the world, especially in the United States and Canada. However, overprescription may underlie opioid misuse. Details on the utilization of prescribed opioids after nonoperative treatment of fractures and disl...
Background:
Quality assessment of vascular anastomosis primarily depends on the experience of the treating surgeon. This highlights the need for an objective index. The main goal of our study was to establish a method of assessing the quality of vascular anastomosis in digit replantation.
Methods:
A total of 182 digits from 141 patients were inc...
Objectives: Nerve transfer has been developed to restore partial function after serious nerve injuries, for example, restoring bladder control after spinal cord injury (SCI). Our aim here was to establish a preclinical proof-of-concept model using nerve transfer for restoring anorectal function after SCI.
Setting: We used laminectomy to model SCI,...
Background:
Fourth and fifth carpometacarpal fracture-dislocations with unsatisfactory closed reduction commonly require later open reduction and internal fixation. However, the optimal method of internal fixation for these is unknown. The purpose of this study was to determine through objective clinical measures which method is superior for fourt...
Background:
Irrigation is one of the key procedures in open fracture management to eliminate pathogens and prevent infection. Metal ion deprivation could inhibit bacterial adhesins and weaken adhesion to the host tissue. EDTA in solution can competitively bind to a metal ion and thus might be able to inhibit bacterial adhesins.
Questions/purposes...
Fifth metacarpal neck fracture commonly requires open reduction and internal fixation. Locking plate was widely adopted in the treatment of fifth metacarpal neck fracture as first-line choice for fixation. Patients with fifth metacarpal neck fracture receiving locking plate fixation were included for analysis. Features of internal fixation includin...
Background:
The functional outcomes and therapeutic costs between digit replantation and revision amputation has remained controversial.
Methods:
Total 1023 patients with single digit traumatic amputation or devascularization who received successful digit replantation (failure excluded) or revision amputation from 1 January 2013 to 1 January 201...
The purpose of this study was to identify the risk factors of hand injuries in manual workers. Total 1672 manual workers with acute hand injuries who visited our emergency department accompanied by their colleagues from 1 March 2014 to 1 March 2017 were included in this study. One accompanied colleague with identical work task was chosen randomly a...
Background:
The primary objective of this study was to investigate whether the application of antithrombotic therapies affects the success rate of digit replantation.
Methods:
Total 477 digits of 319 patients who received dextran with low molecular weight heparin (dextran-LMWH), dextran with prostaglandin E1 (dextran-PGE1), or no antithrombotic...
MicroRNA (miRNA) has great potential to treat a wide range of illnesses by regulating the expression of eukaryotic genes. Biomaterials with high transfection efficiency and low toxicity are needed to deliver miRNA to target cells. In this study, a biodegradable and biocompatible cationic polymer (PDAPEI) was synthetized from low molecular weight po...
Fracture of fifth metacarpal neck commonly requires open reduction and internal fixation. However, the current methods of internal fixation in fifth metacarpal neck fractures remain unsatisfactory. Patients with fractures of fifth metacarpal neck received open reduction and internal fixation with either locking plate in combination with two crossed...
Aims . In this work, the main objectives were to investigate the clinical characteristics and bacterial spectrum present in open fractures contaminated by seawater. Methods . We conducted a retrospective cohort study and included all patients with open fractures from 1st January, 2012, to 31st December, 2015, in our hospital. Patients were grouped...
Objectives. We evaluated the results of digital lengthening by distraction and second-stage bone graft. Methods. We treated finger deficiency of 201 digits in 104 patients (68 males, 36 females) by digital distraction and second-stage bone graft. The distraction was performed with a rate of 1 mm/day (for the first ten days) and 0.5 mm/day followed...
PurposeThe primary objective of this study was to evaluate factors that influence the survival rate after digit replantation. MethodsA total of 291 digits of 200 patients who received digital replantation after complete amputation from 1 January 2014 to 31 December 2015 were included in this study. Univariate and multivariate analysis were performe...
Objective:
To study the feasibility and advantages of preparing an animal model of defecation reconstruction after spinal cord injury in rats by mechanical polishing method.
Methods:
Forty adult female Sprague Dawley rats (weighing, 250-300 g) were randomly divided into 2 groups (n=20). The lamina was opened by mechanical polishing method to exp...
Autonomic and somatic components participate in the defecation process in mammals, combining signals from the brainstem and forebrain. The innervation pattern involved in micturition in rats has been well studied, while defecation has been less studied. The aim of the present study was to identify the most important sensory and motor nerves of the...
Among the many types of spinal fractures reported, thoracolumbar fracture is the most common; it is characterized by medullary cone injury, functional impairment of the sensory and motor nerves and atonic bladder [1-3]. Atonic bladder leads to severe urinary retention, refractory urinary infections, and even chronic renal failure, making it the mai...
To assess the short-term effect of the mini-invasive surgical method by Achillon in repair of acute achilles tendon rupture.
Between December 2009 and February 2010, 11 patients (11 feet) with acute achilles tendon ruptures were treated, including 8 males (8 feet) and 3 females (3 feet) with an average age of 35.4 years (range, 23-58 years). There...
Citations
... Simultaneously, calcium phosphate nanosheets were released from the gel pores to promote bonedefect repair. [25] ...
... The skeletal system also plays important functions in hematopoiesis and metabolism [2]. Skeletal aging refers to the gradual structural and functional degeneration of bone and joint tissues with age, which is mainly manifested by the depletion of skeletal system-related stem cells, loss of bone mass, alteration of bone microarchitecture, reduction of bone strength, degeneration of cartilage, and sclerosis of subchondral bone [3][4][5]. ...
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... 5,19,24 The risk factors for PLP in this study may be due to the role of central mechanisms such as cortical functional reorganization, central sensitization, and pain memory. [25][26][27] It is undeniable that detailed epidemiological studies can provide more clues to reveal the mechanism of the phantom limb phenomenon. ...
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... Their results suggested that iPSC-sEVs represent a safer alternative for therapeutic applications in ischemic myocardial damage (Adamiak et al., 2018). A group of studies revealed the neuroprotection effect of ESC-sEVs and iPSC-sEVs in the aged mice and rats Li et al., 2023;Niu et al., 2023;Xia et al., 2021). These researches suggested the great clinical potential of PSC-sEVs for aging-related diseases especially under such an aging society. ...
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... Recent advancements have demonstrated the effectiveness of treatments that directly regulate gene expression in various diseases like Alzheimer's at clinical stages. Thus, it appears that treatments with minimal side effects that can modulate molecular pathways could be the most advantageous for osteosarcoma [22]. In this context, the nanoscience in combination with medicine has emerged in the realm of cancer therapy. ...
... In DMM surgery, the medial meniscotibial ligament (MMTL) is transected and this imitates the histopathology of OA, resulting in a highly consistent OA condition with a slower progression. Surgical DMM will be performed with an operating stereomicroscope to achieve more robust results and reduce unnecessary waste [23]. The remaining mice will receive a sham surgery. ...
... To determine immune polarization state associated with elevated SEMA3C, we assessed the endogenous transcript and protein levels of SEMA3C in cultured BV2 cells (which are microglial cell lines) after activation with LPS (lipopolysaccharide)/IFN-g or IL-4/IL-13 ( Figures 3A-3C). 28,29 Compared to SEMA3C expressed by control microglia and IL-4/IL-13-induced microglia, the levels of SEMA3C expressed by (E) SEMA3C protein expression at the lesion site detected by western blotting and was quantified (data are represented as mean G SD). Significant differences among groups in panel E were evaluated by one-way ANOVA and post hoc Dunnett's tests for all panels; *p < 0.05; **p < 0.01; and ***p < 0.001 versus the shamoperated control group (n = 3 mice per group). F (4, 10) = 8.489, R squared = 0.7725, p value = 0.0030 in ANOVA summary. ...
... Bone marrow adipose tissue (BMAT) is a dynamically changing tissue associated with osteoporosis, bone tumors, etc [52][53][54]. Different studies have found that studies using 1.5 T magnetic resonance equipment based on chemical shift-encoded water-fat imaging with multiple gradient echoes [55] or T1 Dixon imaging [56] to measure bone marrow fat proportions in parts of the spine (C3-L5), pelvis, ribs, and limb bones have found that age correlates with the spine or trunk bone marrow adiposity ratio correlates with age. Bone marrow fat proportions can be a potential marker for detecting skeletal aging. ...
... As shown in Figure 8b and c, the relative hemolysis rates for both ZIF-8@ZIF-67 and BBH@ZIF-8@ZIF-67 were below the critical range for biomaterials' blood compatibility (less than 5 %) at a concentration of 200 μg/mL, demonstrating excellent blood compatibility. [35] This indicates the excellent biocompatibility of ZIF-8@ZIF-67 as a potential drug delivery carrier. ...
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... In recent years, nerve transfer has emerged as a novel approach for CPN injury treatment. Transferring the soleus muscular branch of the tibial nerve to the deep fibular nerve has shown promise in CPN injury repair and the restoration of ankle dorsiflexion [17,18]. Additionally, the double transfer of tibial nerve branches to the flexor digitorum longus and lateral head of the gastrocnemius to the deep peroneal nerve has proven beneficial in restoring motor function for certain patients [19]. ...
