Xiang Li's research while affiliated with Fudan University and other places

... So far, the majority of mNGS research on blood samples has primarily focused on sepsis. Studies have concluded that blood mNGS testing is helpful for the etiological diagnosis of sepsis with higher sensitivities (75-90%) compared to blood culture, and with a shorter turnaround time [18][19][20][21][22]. It also holds promise for diagnosing fever of unknown origin, suggesting that mNGS could significantly reduce unnecessary antibiotic consumption [23]. ...

... In this study, we analyzed the tomographic status together with fundamental laboratory parameters to evaluate patients with COVID-19 at the time of admission, as was suggested by Li X et al. The usefulness of computed tomography for the diagnosis and prediction of mortality from COVID-19 was evaluated, and we obtained similar findings [52]. ...

... These limitations should be considered when interpreting the findings and generalizing them to broader populations. Huang et al. (2021) conducted a study that combined CT scans, radiomic features, and symptoms to differentiate between COVID-19 and influenza pneumonia. They achieved a promising accuracy of 0.90 and an AUC of 0.96 using this approach. ...

... In addition, one characteristic of acute respiratory distress syndrome due to COVID-19 is the excessive amount of extravascular water that is present (22,23). Furthermore, a previous study that compared CT findings of COVID-19 with those of viral pneumonia due to other viruses showed differences in various findings, and COVID-19 showed vascular thickening more frequently in comparison to viral pneumonia due to other viruses (24,25). In the present study, vascular lesions themselves could not be easily evaluated due to the small sample size. ...

... One observational study [30] without radiomics application in the research and two observational studies [31,32] with a repetitive patient population were excluded. After the article selection process, seven articles were used in the qualitative analysis [33][34][35][36][37][38][39], and six articles were further used in the meta-analysis. The PRISMA flowchart is provided in Figure 1. ...

... Hypoxemia has been reported to decrease LPL activity in the epididymis of rats, and contribute to the overproduction of reactive oxygen and nitrogen species [71,72]. Studies using obese and diabetic animals models with ED found that, in the corpus cavernosum, this condition was combined with high levels of ROS and NO, upregulation of miR-328a [73,74], and downregulation of the Long noncoding RNA myocardial infarction associated transcript (lncRNA-MIAT). This molecular disturbance of the NO pathway impaired erectile function [73,75], which could be accelerated by increased LPL expression [75], a gene also known to have an insulin resistance action [74,[76][77][78] (Fig. 4). ...

... Li et al. (96) recently reported that ammonium tetrathiomolybdate enhanced cell growth at low concentrations by increasing METTL3 expression in LUAD. Inhibition of METTL3 significantly attenuated proliferation by enhancing the expression of the eukaryotic translation initiation factor (eIF), underscoring the pivotal role of METTL3 in governing protein synthesis and cellular growth (96). ...

... Owing to its outstanding antioxidant properties, hydrogen sulfide(H 2 S) gas therapy is promising. H 2 S can inhibit NETosis and the release of NETs by inhibiting the accumulation of ROS, leading to improved diabetic wound healing [13]. On top of that, H 2 S has a significant impact on the regulation of physiological and pathological processes, including angiogenesis promotion, cell proliferation, and inflammation attenuation [14]. ...

... Three enzymes that produce H 2 S are reported to be differentially expressed in tumor tissues of different tissue origins [9] and are involved in regulating tumorigenesis and progression (Table 1). Studies have shown that its role in tumors generally exhibits a biphasic bell-shaped effect [10]. Endogenous or low concentrations of exogenous H 2 S promote cancer cell development by stimulating angiogenesis, increasing mitochondrial bioenergy, and antioxidant. ...

... Excessive ROS in the diabetic wound damages cells and ultimately delays wound healing [10]. Diabetic neutrophils are more prone to neutrophil extracellular trap formation(NETosis) and release neutrophil extracellular traps(NETs), impairing wound healing [11,12]. Owing to its outstanding antioxidant properties, hydrogen sulfide(H 2 S) gas therapy is promising. ...