William Moody's research while affiliated with University of Cambridge and other places
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Publications (3)
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous immune population with diverse immunosuppressive functions in solid tumors. Here, we explored the role of the tumor microenvironment in regulating MDSC differentiation and immunosuppressive properties via signal-regulatory protein alpha (SIRPα)/CD47 signaling. In a murine melanoma model,...
Successful establishment of a tumour relies on a cascade of interactions between cancer cells and stromal cells within an evolving microenvironment. Both immune and non‐immune cellular components are key factors in this process, and the individual players may change their role from tumour elimination to tumour promotion as the microenvironment deve...
Citations
... Известно, что CAF продуцируют белки ЕСМ, которые в свою очередь модулируют транспорт иммунных клеток и регулируют их функциональный статус [18]. Показано, что матрицы с превалирующим количеством коллагена реализуют преимущественно проонкогенные эффекты, в то время как ECM, богатые фибронектином, вызывают иммуносупрессию опухолевых клеток [19]. ...
