William L. Hasler's research while affiliated with Mayo Clinic - Scottsdale and other places

... Robust quantitative data on CVS episode characteristics were provided by a preliminary study of the natural history of the disorder in adults. 21 In this study, 61/88 (69.3%) reported at least 1 CVS episode over 6 months of observation, with a mean episode duration of 7.1 ± 12.0 days. However, 26.7% of episodes were >7 days long exceeding the limit proposed by the Rome criteria. ...

... Migraine is a complicated genetic disorder characterized by episodes of moderate-to-severe headaches that are usually unilateral and are frequently accompanied by nausea and increased sensitivity to sound and light. A migraine attack can cause intense pain that affects a person from carrying on their daily activities and can last for hours or even days [2][3][4]. ...

... In IBS, alterations in lymphocyte populations, including changes in B and T lymphocyte counts and activation levels, have been documented. These immune changes are linked to increased eosinophil counts in the duodenum of patients with functional dyspepsia (FD) and elevated colonic mast cell numbers in those with IBS [14]. Additionally, elevated levels of α4+β7+ gut-homing T cells in the bloodstream are implicated in the pathophysiology of FD and IBS. ...

... Primary diseases such as pharyngeal trauma, severe pneumonia, and other injuries that cause vomiting disorders only require treatment, such as pharyngitis and cellulitis, which can be treated with oral broad-spectrum antibiotics, anti-inflammatory drugs, and analgesics [18]. For the above patients, if they have refractory vomiting symptoms, a rumen fistula can be established to alleviate long-term vomiting symptoms, and then diet and standing water treatment can be carried out through this method [19]. In valuable diseases, if the cause is in the abdomen, surgical treatment is necessary. ...

... 140 Gastric peroral endoscopic myotomy (G-POEM) is considered a safe and promising technique for the management of refractory DGP. 141 Several meta-analyses have shown that G-POEM treatment is effective in improving the clinical symptoms of patients with gastroparesis, and that GCSI scores and gastric emptying scintigraphy are significantly improved. 142,143 An evaluation of the longterm outcome of patients with refractory gastroparesis treated with GPOEM reveals a clinical success of 86.5% for DGP at 4 years of follow-up, with a significant improvement in patients' quality of life. ...

... Choice of substrate. The North American Consensus guidelines recommend a substrate dose of 75 g glucose (preferred over 50 g) or 10 g lactulose (30). However, European guidelines favor 50 g for glucose or 10-20 g of lactulose (15). ...

... While navigating through the gastrointestinal tract, the capsule continuously records various measurements and wirelessly transmits real-time data to a receiver worn by the patient on their waist throughout the study. While numerous studies have explored the utility of WMC in identifying multiregional dysmotility in various conditions (such as diabetes [18], chronic constipation [19] and gastroparesis [20]), no current data are available regarding the GI tract transit profile among patients with CD and other gluten-related disorders, such as NCGS. ...

... The intragastric defense barrier damage by acid suppression therapy makes it easier for upstream opportunistic pathogens to enter the small intestine [10][11][12]. Congenital or postoperative intestinal anatomical malformations increase local food residues and bacterial accumulation, like intestinal diverticulum, Roux-en-Y anastomosis, or small bowel resection [13,14]. Multiple pathophysiological mechanisms contribute to abdominal discomforts including carbohydrate fermentation and improper metabolites, GI chronic inflammation, mucosal immune deficiency, increased gut permeability, food intolerance, and antigenemia [15,16]. ...

... Until now, gastric motility has not been extensively studied with MRI; there exist only a few articles focusing on it. The study by Heissam et al. [59], based on fifteen healthy adults, compared the motility cine-MRI, performed with semi-automated techniques, with simultaneous water perfused manometry, using water as a contrast agent and demonstrating a strong correlation between the two methods. Another study, by Hosseini et al. [60] performed cine-MRI on four healthy volunteers, using pineapple juice as contrast and demonstrating the possibility of using MRI to measure and quantify gastric motility in human participants, even quantifying different motility patterns in different gastric portions. ...

... While in terms of treatment efficacy, the response of female FD patients was also lower than that of males [39]. Therefore, gender could be served as a robust predictor of FD symptoms and QoL improvements, which is similar to the results of Lee AA et al. [40]. Other than gender, the subtype of disease was also found to be another key predictor of acupuncture efficacy for FD. ...