Wenyong Lin's research while affiliated with Shanghai University of Traditional Chinese Medicine and other places
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Publications (5)
Coronary heart disease remains a major global health challenge, with a clear need for enhanced early risk assessment. This study aimed to elucidate metabolic signatures across various stages of coronary heart disease and develop an effective multiclass diagnostic model. Using metabolomic approaches, gas chromatography–mass and liquid chromatography...
Aim: The Shexiang Baoxin Pill (SBP) has been extensively used to treat cardiovascular diseases in China for four decades, and its clinical efficacy has been widely approved. However, the mechanism by which this is achieved remains largely unexplored. Research attempting to understand the underlying mechanism is ongoing, but the findings are controv...
Aim: The present study aimed to explore the potential herb-drug interactions (HDI) between Shengmai injection (SMI) and losartan potassium (LOS) based on the expression profiles of cytochromes P450 (CYP450) and drug transporters in rat and in vitro .
Methods: Different concentrations of SMI were used to explore the influence of SMI on the antihyper...
Ethnopharmacology relevance
Suxiao jiuxin pill (SJP) is a Chinese medical drug with anti-inflammatory, anti-apoptotic, and vasodilatory function. It is widely used in combination with other drugs for the treatment of coronary heart disease (CHD) and angina. Nevertheless, the effect of SJP on Cytochrome P450 (CYP450) enzymes and transporters’ activi...
The incidence and mortality of coronary heart disease (CHD) continue to increase every year in China. It has become a serious public health concern, threatening people's health. The combination of herbs and drugs has become a common mode of treatment for various chronic diseases such as CHD and chronic lung disease. Clinical studies have shown that...
Citations
... Notably, ST can capture the interactions of TCM between cells and tissues, assisting in revealing the intricate mechanisms of TCM action and the patterns of multipathway regulation, making it a powerful tool for revealing new pathways of TCM. To elucidate the mechanism by which the traditional Chinese medicine formula Shexiang Baoxin Pill (SBS) protects the heart, researchers have combined ST with single-nucleus RNA sequencing to assess the effects of SBS on myocardial cell types and subpopulation states [127]. They discovered that SBS could increase the gene expression of Nppb and Npr3 in the infarct area of the heart, regulating vascular generation mediated by endocardial cells. ...
... Recently, the usage of Shengmai injection in treating cardiovascular diseases has raised concern, such as the treatment of hypertension and chronic heart failure (Wang et al., 2020a;Wang et al., 2020b;Zhang Y. et al., 2020;Cao et al., 2022). Shengmai injection is formed from Shengmai San by modern drug extraction methods, which increases the absorption rate and bioavailability of the active ingredients to achieve better efficacy Niu et al., 2022). Shengmai San is a traditional Chinese herbal prescription originated in the Jin dynasty. ...
... 关于中西药联用安全性的基础研究主要集中于如何分 析联用对CYP450酶和转运体活性的影响 [12] . [13] . ...
Reference: 数字孪生融入中西药联用个体化临床安全性评价思路
... Complementary therapies could also improve treatment outcomes. [13]. The efficacy and safety of DCD in treating angina, acute cholecystitis, type 2 diabetes, fatty liver disease, and AP have been reported in numerous clinical trials [14][15][16][17][18]. DCD in combination with ulinastatin and somatostatin has recently been used to treat severe AP. ...
